Medical Oncology
- Qualifications
- Clinical Care
- Areas of Research Interest
- Current Research Projects
- Collaborations
- Research Opportunities for Students
- Peer-Reviewed Publications
- Book Chapters
- Other Publications
- Abstracts
Professor Paul de Souza is Foundation Professor of Medical Oncology, a specialty in medicine involving the treatment of patients with cancer. Medical Oncologists care for patients with cancer, and sometimes use chemotherapy, medications or other therapies in order to prolong life or improve quality of life.
Qualifications
BScMed, MBBS, MPH Syd, PhD UNSW, FRACP.Clinical Care
Professor de Souza has been involved in clinical work every year since his internship, including tenure at the University of Virginia, USA, where he was appointed to the Medical Faculty. Professor de Souza led the genitourinary oncology service, supervised Clinical Fellows, and ran his own laboratory research program. Since returning to Australia, he has continued to have a heavy clinical load seeing up to 100 patients a week, and currently sees approximately 50 patients per week. He has had medical oncology experience as a consultant medical oncologist in two continents and in five hospitals.Areas of Research Interest
Professor de Souza has a broad interest in cancer research in the fields of preclinical investigation of novel compounds, synergistic combinations of therapies, targeted therapies, signal transduction, cell biology, pharmacokinetics, pharmacodynamics, clinical pharmacology, translational research and early Phase clinical trials. He also has research interests in genitourinary cancers (particularly prostate and renal cancers), as well as brain tumours.Professor de Souza's main areas of interest are:
- Translational drug development in cancer (preclinical to early Phase clinical trials of novel treatments)
- Urological cancer's, including renal, bladder and prostate cancer, signal transduction and mechanisms of drug resistance
- Neurological cancer, especially glioblastoma multiform
- Angiogenesis and biomarkers in cancer
- Quality of Life in cancer patient
Current Research Projects
| Type | Amount | Year |
| Prostate Cancer Foundation of Australia – PCFA grant # PG3009: de Souza PL, Scott K, Graham G, Young P, Liauw W, Russell P. 1 Feb 2010 – 31 Jan 2013. A Translational and Pharmacokinetic study of a Novel, Orally-active, Targeted Treatment for Hormone Refractory Prostate Cancer. Role CIA | $450,000 over 3 years | 2010-2012 |
| St George Hospital Cancer Grants Top Up Funding. de Souza PL, Scott K, Graham G, Young P, Liauw W, Russell P. 1 Feb 2010 – 31 Jan 2013. A Translational and Pharmacokinetic study of a Novel, Orally-active, Targeted Treatment for Hormone Refractory Prostate Cancer. Role CIA | A$70,000 | 2010 |
| Cancer Institute of NSW Research Equipment Grant (Grant ID#: 10/REG/1-16) | A$ 97,438 | 2010-2011 |
| Cancer Institute of NSW Research Equipment Grant Seahorse Extracellular Flux (XF) Analyzer for the Multi-Disciplinary Sydney Cancer Research Core Facility Richardson DR, Boyer, M., Weninger, W., Scolyer, R.A., Halliday, G., Lee, C.S., Hambley, T., Murray, M., Lay, P., Mason, R.S., Joshua, D., Murphy, C., McLachlan, A., King, N.J.C, Dong, Q., Naresh, K., dos Remedios, C., Rendina, L., Davies, M., Assinder, S., Kovacevic, Z., Zreiqat, H., Vemulpad, S., Bao, B., Yu, Y., Bishop, A., Vanderberg, R., Zhang, D., Groundwater, P., Hawkins, C., Kalinowski, D., De Souza, P., Lane, D., Ryan, R., Hambly, B., Jansson, P., Moscato, P., Saletta F., Fraser, S., Sharland, A., Lovejoy, D., Codd, R., Jamie, J., Byrne, M., Kench, J., Suryo Rahmanto, Y., Lai, D. | A$315,000 | 2011-2012 |
| Cancer Institute of NSW Translational Cancer Research Unit Grant (Grant ID: 11/TRU/1‑09) de Souza P, Lee S, Bokey L, Barton M, Apte M, Agar M. South West Sydney Translational Cancer Unit establishment grant | $1.793,000 | 2011-2014 |
| TOTAL | $2,725,438 |
|
Collaborations
Professor de Souza has multiple research collaborations, including investigations from UWS, UNSW, and other institutions in Australia and overseas. The collaborations span basic science research to clinical trials and other types of research.Research Opportunities for Students
There are abundant opportunities for research for undergraduate and postgraduate students. These range from small clinical projects to statistical analyses and even laboratory experiments.Peer-Reviewed Publications
For a full list of Professor de Souza's, refer to Peer-Reviewed Publications (opens in a new window) [PDF - 639.36kb].Book Chapters
Gano CA, Scott K, Bucci J, Greenfield H, Dong Q, de Souza PL. dietary manipulation for therapeutic effect in prostate cancer. In: Cancer Prevention, published by InTech (opens in a new window).Other Publications
- de Souza P. Cancer Drug Toxicities and Anaesthesia. Australian Anaesthesia 2007 (Ed: Richard Riley), pages 71-79.
- de Souza P. Management of opioid side effects - a personal view. Submitted to Australian Anaesthesia 2011.
