Neville D Yeomans


 

Biography

Emeritus Professor Yeomans AM was the Foundation Dean of Medicine at UWS (2004-2009). He was appointed as a Member of the Order of Australia in January 2013 for significant service to tertiary education, research and clinical practice in the field of medicine.

He was educated at Fish Creek State School, Foster High School, Scotch College Melbourne (Senior Scholarship), University of Melbourne (MBBS), Monash University (MD by thesis), University of Copenhagen (Research Fellow) and Harvard University (Research Fellow).

He is a Fellow of the Royal Australasian College of Physicians (RACP), the American College of Gastroenterology, and the American Gastroenterological Association.

He has held hospital appointments at the following Melbourne hospitals: Royal Melbourne Hospital, Alfred Hospital, Austin Hospital and Western Hospital. His most recent academic appointments, before moving to set up the UWS School of Medicine, were as University of Melbourne's Foundation Professor of Medicine at Western Hospital, and Associate Dean (Academic Programs) in The University of Melbourne's Faculty of Medicine, Dentistry and Health Sciences.

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Areas of Research / Teaching Expertise

  • Gastroenterology
  • Peptic ulcer disease
  • Gastrointestinal cell biology
  • Experimental gastric pathology

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Grants / Current Projects

  • The PRECISION study: an international study centred at the Cleveland Clinic, to determine the balance of risks (gastrointestinal and cardiovascular) of COX-2 inhibitors and non-selective nonsteroidal anti-inflammatory drugs.
  • The ASTERIX study, which showed that gastric ulceration caused by low-dose aspirin ingestion can be prevented with a proton pump inhibitor drug.
  • The JUPITER study, which documented the incidence and prevalance of ulcers in patients taking low-dose aspirin.
  • Studies of factors affecting performance in aptitude tests and interviews for medical student selection.
  • NH&MRC funded studies of mechanisms of adaptation by the gastric mucosa to repeated injury, and mechanisms in experimental gastric cancer.
  • Predictors of myocardial (heart muscle) damage in patients with upper gastrointestinal haemorrhage.

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Awards and Recognition

Distinguished Research Prize,
Gastroenterological Society of Australia (2004)

John Sands Medal,
Royal Australasian College of Physicians (2003)

Stewart Scholar in Medicine
The University of Melbourne (1977-1980)

Alfred Hospital Research Scholarship (1974-5)

Royal Australasian College of Physicians, Overseas Travelling Scholarship (1973)

National Health & Medical Research Council, Medical Postgraduate Research Scholarship (1970-72)

Edgar Rouse Prize (1965)

T.F. Ryan Medal in Medicine (1965)

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Selected Publications

1. Griffin BN, Harding DW, Wilson IG, Yeomans ND. Does practice make perfect? The effect of coaching and retesting on selection tests used for admission to an Australian medical school. Med J Aust 2008; 189: 270-273.

2. Yeomans ND, Lanas A, Labenz J, van Zanten SV, van Rensberg C, Rácz I, Tchernev K, Karamanolis D, Roda E, Hawkey C, Nauclér E, Svedberg L-E. Efficacy of esomeprazole (20 mg once daily) for reducing the risk of gastroduodenal ulcers associated with continuous use of low-dose aspirin.Am J Gastroenterol 2008; 103: 2465-2473.

3. Yeomans ND, Naesdal J. Systematic review: ulcer definition in NSAID ulcer prevention trials. Aliment Pharmacol Ther 2008; 27 (6): 465-472.

4. Jackson C, Judd L, Menheniott T, Kronborg I, Dow C, Yeomans N, Boussioutas A, Robb L, Giraud A. Augmented gp130-mediated cytokine signalling accompanies human gastric cancer progression. J Pathol 2007; 213: 140-151.

5. Scheiman JM, Yeomans ND, Talley NJ, Vakil N, Chan FKL, Tulassay Z, Rainoldi JL, Szczepanski L, Ung K-A, Kleczkowski D, Ahlbom H, Næsdal J, Hawkey C. Prevention of ulcers by esomeprazole in at-risk patients using non-selective NSAIDs and COX 2 inhibitors. Am J Gastroenterol 2006; 101: 701-710.

6. Yeomans ND, Lanas AI, Talley NJ, Thomson ABR, Daneshjoo R, Eriksson B, Appelman-Eszczuk S, Långström G, Naesdal J, Serrano P, Singh M, Skelly MM, Hawkey CJ. Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin. Aliment Pharmacol Ther 2005; 22: 795-801.

7. Yeomans ND, Chan FKL. Being on nonsteroidal anti-inflammatory drugs. In: Weinstein, WM, Hawkey CJ, Bosch J (eds.). Clinical Gastroenterology and Hepatology: The Modern Clinician's Guide. Elsevier Science, London 2005; 133-137.

8. Hawkey CJ, Talley NJ, Yeomans ND, Jones R, Sung JJY, Långström G, Naesdal J, Scheiman J. Improvements with esomeprazole in upper gastrointestinal symptoms in patients taking non-steroidal anti-inflammatory drugs, including selective COX-2 inhibitors. Am J Gastroenterol 2005; 100: 1028-1036.

9. Alderman BM, Ulaganathan M, Judd LM, Howlett M, Parker LM, Yeomans ND, Giraud AS. Insights into the mechanisms of gastric adaptation to aspirin-induced injury: a role for regenerating protein but not trefoil peptides. Lab Invest 2003; 83: 1415-1425.

10. Elliott SL, Yeomans ND. Future directions of medical education in Australia. Intern Med J 2003; 33: 360-1.

11. Birkett D, Catto-Smith A, Cosh D, Crotty B, Dammery D, Desmond P, King S, Liddle C, Leggett B, Pavli P, Reeve J, Wilson A, Yeomans N. Therapeutic guidelines: gastrointestinal, Version 3. Therapeutic Guidelines Ltd: Melbourne. 2002; 192pp.

12. Hawkey CJ, Wilson I, Naesdal J, Långström G, Swannell AJ, Yeomans ND. Influence of sex and Helicobacter pylori on development and healing of gastroduodenal lesions in non-steroidal anti-inflammatory drug users. Gut 2002; 51: 344-350.

13. Hawkey CJ, Naesdal J, Wilson I, Långström G, Swannell AJ, Peacock RA, Yeomans ND. Relative contribution of mucosal injury and Helicobacter pylori in the development of gastroduodenal lesions in patients taking non-steroidal anti-inflammatory drugs. Gut 2002; 51: 336-343.

14. Yeomans N, Wilson I, Långström G, Hawkey C, Naesdal J, Walan A, Wiklund I. Quality of life in chronic NSAID users: a comparison of the effect of omeprazole and misoprostol. Scand J Rheumatol 2001; 30: 328-334.

15. Ulaganathan M, Familari M, Yeomans ND, Giraud AS, Cook GA. Spatio-temporal expression of trefoil peptide following severe gastric ulceration in the rat implicates it in late-stage repair processes. J Gastroenterol Hepatol 2001; 16: 506-512.

16. Taupin D, Pederson J, Familari M, Cook G, Yeomans N, Giraud AS. Augmented intestinal trefoil factor (TFF3) and loss of pS2 (TFF1) expression precedes metaplastic differentiation of gastric epithelium. Lab Invest 2001; 81: 397-408.

17. Yeomans ND, Garas G, Hawkey CJ. The NSAIDs controversy. In, Marshall BM (ed.), Helicobacter pylori. Gastroenterology Clinics of North America 2000; 29: 791-805.

18. Alderman BM, Cook GA, Familari M, Yeomans ND, Giraud AS.  Resistance to apoptosis is a mechanism of adaptation of rat stomach to aspirin. Am J Physiol 2000; 278: G839-846.

19. Tran CP, Cook GA, Yeomans ND, Thim L, Giraud AS. Trefoil peptide TFF-2 (spasmolytic polypeptide) potently accelerates healing and reduces inflammation in a rat model of colitis. Gut 1999; 44: 636-642.

20. Yeomans ND, Tulassay Z, Juhasz L, Racz I, Howard JM, van Rensburg CJ, Swannell AJ, Hawkey CJ.  A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal anti-inflammatory drugs.  N Engl J Med 1998; 338: 719-726.

21. Hawkey CJ, Karrasch JA, Szczepanski L, Walker DG, Barkun A, Swannell AJ, Yeomans ND.  Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. N Engl J Med 1998; 338: 727-734.

22. Skeljo MV, Cook GA, Elliott SL, Giraud AS, Yeomans ND.  Gastric mucosal adaptation to diclofenac injury in rats.  Dig Dis Sci 1996; 41: 32-39.

23. Elliott SL, Ferris RJ, Giraud AS, Skeljo MV, Yeomans ND.  Indomethacin damage to rat gastric mucosa is markedly dependent on luminal pH.  Clin Exper Pharmacol Physiol 1996; 23: 432-434.

24. Elliott SL, Yeomans ND, Buchanan RRC, Smallwood RA.  Efficacy of 12 months' misoprostol as prophylaxis against NSAID-induced gastric ulcers.  Scand J Rheumatol 1994; 23: 171-176.

25. Yeomans ND, Lambert JR.  Infections of the stomach and duodenum.  In: Haubrich WS, Schaffner F, Berk JE.  Bockus Gastroenterology. 5th Edn. W.B. Saunders: Philadelphia. 1994; pp 805-815.

26. Yeomans ND, Prichard PJ, Jones DB, Buckle PJ, McNeil JJ, Louis WJ, Smallwood RA.  Morning or evening dosing with low dose omeprazole: effects on 24 h gastric acidity profiles in duodenal ulcer patients.  Scand J Gastroenterol 1986; 21 (Suppl. 118): 152-153.

27. Prichard PJ, Yeomans ND, Mihaly GW, Jones DB, Buckle P, Smallwood RA, Louis WJ.  Omeprazole: a study of its inhibition of gastric pH and oral pharmacokinetics, after morning or evening dosage.  Gastroenterology 1985; 88: 64-69.

28. Giraud AS, Yeomans ND, St John DJB.  Ultrastructure and cytochemistry of the gastric mucosa of a reptile, Tiliqua scincoides.  Cell Tiss Res 1979; 197: 281-294.  

29. Yeomans ND, Trier JS.  Epithelial cell proliferation and migration in the developing rat gastric mucosa.  Devel Biol 1976; 53: 206-216.

30. Yeomans ND.  Etude ultrastructurale et cytochimique des granules muqueux des cellules de la surface et des cryptes de la muqueuse gastrique chez le rat.  Biol Gastroenterol (Paris) 1974; 7: 285-290.  

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Professional Activities

Current board memberships:

  • Australian Medical Council
  • Journal of Gastroenterology and Hepatology (Chair)
  • Ingham Health Research Institute (Director, Chair, Scientific Advisory Committee)
  • Austin Lifesciences (Director of Research)

Previous leadership positions in professional societies:

  • President, Gastroenterological Society of Australia (1997-1999)
  • Councillor, Royal Australian College of Physicians (1995-1997)
  • Councillor (and Chair Education and Research Committee), Asia Pacific Association of Gastroenterology (2000-2008)

 Roles in peer-review of research:

  • Member or Chair of NH&MRC Regional Grants Committee and/or Discipline Panels (1985-2003)

Editor or Associate Editor posts:

  • American Journal of Gastroenterology (2003-2006
  • Internal Medicine Journal (2003-)

Editorial Board memberships:

  • Digestive and Liver Disease (2000-2004)
  • Current Gastroenterology Reports (1999-)
    Canadian Journal of Gastroenterology (1987-1991)
    International Journal of Gastroenterology (1990-1999)
    Therapeutic Advances of Gastroenterology (2008-)

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