Soon Lee

Profile

Name : Soon Lee
School : School of Medicine

^ Back to top

Biography

C. Soon Lee
MD BS (Melb), FRCPA, FRCPath (UK), MIAC, MRACMA.

Professor Lee is Professor and Chair of Pathology at University of Western Sydney. He is currently based at Liverpool Hospital and is a senior pathologist at that hospital and at Royal Prince Alfred Hospital.

He has research interests in cancer pathology particularly in relation to translational work in gastrointestinal, breast, pancreatic-biliary, head and neck and prostate cancers. His work on EGFR in head and neck cancers in the early 1990's resulted in the first and only one of two publications in this area in Australia that has recently resulted in the use of immunohistochemical detection of EGFR in patients with these cancers.

His involvement in multicentre international study on phyllodes tumour of the breast has produced significant insights into the molecular basis of this unusual condition. He and his overseas collaborators from Hong Kong, Singapore and Brazil currently have the largest archival series of these tumours in the world.

Professor Lee is currently Editor-in-Chief of the journal, Pathology (SCI impact factor of 1.77 in 2007) and is a member of the editorial board of the Journal of Clinical Pathology. He is also Associate Editor of the journal, Internet Journal of Oncology. He has published over 120 manuscripts in high impact factor international journals in cancer research. His research programmes are currently funded by NHMRC, Cancer Institute NSW, Cancer Australia and Royal Australian and New Zealand College of Radiologists.

^ Back to top

Areas of Research / Teaching Expertise

  • Cancer Pathology
  • Surgical Pathology
  • Cytology
  • Breast Cancer
  • Colorectal Cancer
  • Head and Neck Cancer
  • Prostate Cancer
  • Pancreatic Cancer

^ Back to top

Grants / Current Projects

NHMRC Programme Grant Year 2004-2008
Mechanisms for breast and prostate cancer development and progression: Implications for improved clinical management and treatment
$4,740,000
Sutherland R, Daly R, Musgrove E,
Ormandy C. Grygiel J, Hayes VM, Henshall SM,
Kench JG, Lee CS, Stricker PD


Cancer Institute NSW Programme Grant 2005-2009
Markers of prognosis and therapeutic responsiveness in prostate cancer
$3,750,000
Clark S, Henshall S, Russell P, Horvath L, Sutherland, Kench J, Lee CS, Molloy P, Grygiel J, Stricker P, Boyer M


NHMRC Programme Grant 2006-2010
Molecular predictors of risk, progression and treatment
response in melanoma
$7,895,340
Kefford R, Thompson J, Hersey P, Mann G, Scolyer R Rizos H, Zhang XD, Lee CS, Bastian B, Trent J.


Cancer Institute NSW Programme Grant 2007-2011
Use of proteomic analyses to improve the management of colorectal cancer (CRC) - the SCRIPT for CRC Project
$3,750,00
Clarke S, Bokey L, Baker M, Molloy M, McKay M, Chapuis P, Horvath L, Lin B, Chan C, Kohonen-Corish M, Roberson G,
Beale P,Christopherson RI, Lee CS, Hong A, Solomon MJ


Royal Australian and New Zealand College of Radiologists
Project Grant 2008
The in vitro effect of human papillomavirus on the radiosensitivity of oropharyngeal cancer cells
$15,000
Hong A, Rose B, Lee CS, Zhang M, Tran N, Milross C
University of Western Sydney 2008

The University of Western Sydney 2008
Use of confocal microscopy for the Pathology Unit's Cancer Pathology Research Group (CPRG)
$225,000
Hennessy, Annemarie; Coorssen, Jens; Lee, Soon

University of Western Sydney 2008
Can transient elastography distinguish advanced liver disease from compensated cirrhosis and early liver disease and do liver stiffness changes correlate with clinical improvement, stability or progression over time in the diverse ethnic population of SWS?
$25,000
Hennessy, Annemarie; Turner,Ian; Levy, Miriam; Lee, Soon; Kidson, Bronwynne

^ Back to top

Awards and Recognition

Academic and Professional Qualifications
FRCPath (UK), Royal College of Pathologists 2003
MRCPath (UK), Royal College of Pathologists  2000
MRACMA, Royal Australian College of Medical Administrators 1997
MIAC, International Academy of Cytology 1996
FRCPA, Royal College of Pathologists of Australasia 1994
MD, University of Melbourne 1993
MBBS, University of Melbourne 1987

Other Awards
Fellow Royal Society of Medicine (U.K.)
Fellow Royal Microscopical Society (U.K.)
Member American College of Physician Executives

^ Back to top

Selected Publications

Peer Reviewed Journal Publications
Tse GM, Lui PC, Vong JS, Lau KM, Putti TC, Karim R, Scolyer RA, Lee CS, Yu AM, Ng DC, Tse AK, Tan PH.Increased epidermal growth factor receptor (EGFR) expression in malignant mammary phyllodes tumors. Breast Cancer Res Treat. 2008 Apr 29.

Cooper WA, Kohonen-Corish MR, Zhuang L, McCaughan B, Kennedy C, Screaton G, Sutherland RL, Lee CS. Role and prognostic significance of tumor necrosis factor-related apoptosis-inducing ligand death receptor DR5 in nonsmall-cell lung cancer and precursor lesions. Cancer. 2008; 113 (1): 135-142.

Cooper WA, Kohonen-Corish MRJ, Chan C, Kwun SY, McCaughan B, Kennedy C, Sutherland RL, Lee CS. Prognostic significance of DNA repair proteins MLH1, MSH2 and MGMT expression in non-small-cell lung cancer and precursor lesions. Histopathology 2008; 52: 613-622

Doubrovsky A, Scolyer RA, Murali R, McKenzie PR, Watson GF, Lee CS, McLeod DJ, McCarthy WH, Uren RF, Stretch JR, Saw RP, Thompson JF. Diagnostic accuracy of fine needle biopsy for metastatic melanoma and its implications for patient management. Ann Surg Oncol. 2008 Jan; 15(1):323-32.

Murali R, Sharma RN, Thompson JF, Stretch JR, Lee CS, McCarthy SW, Scolyer RA. Sentinel lymph node biopsy in histologically ambiguous melanocytic tumors with Spitzoid features (so-called atypical Spitzoid tumors). Ann Surg Oncol. 2008 Jan; 15(1):302-9.

Murphy NC, Scarlett CJ, Kench JG, Sum EY, Segara D, Colvin EK, Susanto J, Cosman PH, Lee CS, Musgrove EA, Sutherland RL, Lindeman GJ, Henshall SM, Visvader JE, Biankin AV. Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma. Br J Cancer. 2008 Feb 12; 98 (3):537-541

Kaufman A, Storey D, Lee CS, Murali R. Mucinous cyst exhibiting severe dysplasia in gastric heterotopic pancreas associated with gastrointestinal stromal tumour. World J Gastroenterol. 2007; 13 (43): 5781-2.

Seng TJ, Currey N, Cooper WA, Lee C-S, Chan C, Sutherland RL, Kennedy C, McCaughan B, Kohonen-Corish M. DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma. Histopathology 2007;

Patel RS, Rose B, Bawdon H, Hong A, Lee CS, Fredericks S, Gao K, O'Brien CJ. Cyclin D1 and p16 expression in pleomorphic adenoma and carcinoma ex-pleomorphic adenoma of the parotid gland. Histopathology 2007; 51: 691-696

Book Chapters
Lee CS. Harmonisation of EGFR staining procedures. Havas MediMedia Communications, Hong Kong. Asia Pacific Workshop on EGFR, pp 11-12; 2000.

Lee CS. EGFR expression in head and neck squamous cell carcinoma -Results. Havas MediMedia Communications, Hong Kong. Asia Pacific Workshop on EGFR, pp 5-8; 2000

Lee CS. Basic aspects of cancer pathology. In Morris DL, Kearsley J (Eds.) Cancer: A comprehensive guide, pp 21-29. Harwood Academic Publishers, Reading; 1998.

^ Back to top

Professional Activities

The Royal College of Pathologists of Australasia
The Royal College of Pathologists of the United Kingdom
The Royal Australian College of Medical Administrators
The Royal Society of Medicine
The Royal Microscopic Society
The American College of Physician Executives
International Academy of Pathology
International Academy of Cytology
Gastroentrological Society of Australia
Pathological Society of Great Britain and Ireland
University of Melbourne Medical Society
Australian Association of Clinical Biochemists - Associate member 1989
Australian Medical Association - member 1988 to 1992
Resident Medical Association 1988-1991
Australian Association of General Practitioners - Foundation member 1993

 

^ Back to top