Chinese herbs may be key to unlocking dementia
Over 200 Australians with dementia will soon be joining one of the nation's largest clinical trials for a Chinese herbal medicine which, in pilot studies, has been shown to be an effective treatment improving learning and memory.
Sailuotong (SLT) is a complex combination of ginseng, ginkgo and saffron that has been scientifically developed and tested by a combined team from Xiyuan Hospital, China Academy of Chinese Medical Sciences and the National Institute of Complementary Medicine at Western Sydney University.
Over the last 10 years, Sailuotong has been systematically studied in the laboratory and clinical trials.
These preliminary studies have shown Sailuotong improves the cognitive and memory impairment associated with vascular dementia.
Vascular dementia, the second most common form of dementia, maybe associated with numerous mini strokes, some of which may be undetectable to the patient, hypertension and diabetes. The result is memory loss and a decline in cognitive ability.
Chief Investigator of the Phase III clinical trial, Associate Professor Dennis Chang, from the National Institute of Complementary Medicine at Western Sydney University, says Sailuotong is designed specifically for vascular dementia and mixed dementia (Alzheimer's disease and vascular dementia).
"Current pharmaceutical drug treatments for vascular dementia are ineffective because they don't address the multiple factors associated with the disease," says Associate Professor Chang, who specialises in pharmacology and clinical research.
"However in Chinese medicine, the combination of several herbal compounds which work together to address different causes and symptoms of a disease is common.
"Preliminary studies of Sailuotong showed it increased blood flow to the brain and those taking the herbal medicine improved their scores on standard cognitive tests.
"Currently there is no one specific treatment for vascular dementia - if the current Phase III clinical trial is successful, Sailuotong will be a frontline treatment for thousands of people across the world."
Worldwide, 47.5 million people have dementia and there are 7.7 million new cases every yeari. In Australia, there is a new case of dementia every six minutesii.
Over 342,000 Australians are living with dementiaiii and about 20 to 30 per cent of dementia cases are thought to be vascular dementiaiv.
Professor Daniel Chan, clinical trial Principal Investigator and Medical Director of Aged Care and Rehabilitation at Bankstown-Lidcombe Hospital, where a pilot study of Sailoutong was conducted, says patients participating in the trial will take two capsules twice a day for 52 weeks and attend clinical visits so their health can be closely monitored.
Patients in trial at five hospital sites in New South Wales and, later planned sites in Melbourne, Adelaide, Brisbane and Perth, will be randomly selected to receive the active preparation or a placebo.
"Neither the clinician nor the patient will know if they are part of the active or placebo group," says Professor Chan, a specialist in geriatric medicine.
"We'll be using standard clinical tests to assess cognitive ability and psychological wellbeing to determine which patients respond to the treatments during the trial."
For some participants in the trial MRI scans will also be taken to help determine physical changes in the brain.
Associate Professor Chang says Chinese herbal medicines have been used to treat age-related disorders for centuries.
"There are references to herbal remedies being dispensed to boost memory and longevity going back 2,000 years," says Associate Professor Chang.
"The results of the peer reviewed clinical trial of Sailuotong will not only help determine the action of this unique modern herbal medication on learning and memory, but confirm its capacity to deliver significant improvements in daily function and quality of life in patients with vascular dementia."
The study has been approved by the Human Ethics Committees of Western Sydney University (Approval Number H10933), South Western Sydney Local Health District (14/046) and the NSW Guardianship Tribunal (Approval Number: 1/2015).
The researchers acknowledge the support of Shineway Pharmaceuticals for this study.
If you are interested in participating in the research trial please phone the hotline on 02 46203578 or email firstname.lastname@example.org.
30 November 2015
Lyn Danninger, Western Sydney University, M: +61 414 308 701, E: email@example.com
Natalie Connor, National Institute of Complementary Medicine, M: +61 417 259 054, E: firstname.lastname@example.org
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