International Conference on Thrombosis, Bleeding Disorders & Hemostasis

Laboratory Issues and Models of Thrombosis: Reversal of NOADs in Animal Models Understanding of the potential usefulness and limitations of specific animal models and agents is important because of the imminent risk of thrombosis with such antagonists in high-risk patients. Animal studies of anti-IIa and -Xa drugs are said to widely vary due to differences of animal types, timing, location and extent of vascular injury, and the use of tests such as prothrombin and activated partial thromboplastin time, which are not suitable for monitoring these drugs, nor for predicting therapeutic effects of hemostatic agents.