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Associate Professor Qihan Dong

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School of Science and Health

Qualifications

MD, PhD

Biography

Associate Professor Dong has pursued a career in research after being awarded his PhD in 1992. He then worked as a Fogarty Fellow at the National Institutes of Health, USA. On returning to Sydney in 1996, he was appointed as a Senior Research Fellow and Head of the Cancer Biology Group.

Associate Professor Dong joined the University of Western Sydney as an Associate Professor in Human Genetics in the School of Biomedical and Health Sciences in July 2011.

Since 1996 Associate Professor Dong has supervised many PhD and Master's students. Several of them have now completed their degrees and are working in the biomedical field.

Associated Professor Dong joined the University of Western Sydney as an Associate Professor in Human Genetics in the School of Biomedical and Health Sciences in July 2011.

Associate Professor Dong has taken on the responsibility of supervising Senior Registrars from hospitals. So far, two Senior Registrars have spent one year (full time) in his laboratory.

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Research

Associate Professor Dong's research interests lie in the oncogenic signalling pathway (PTEN/PI3K/AKT, RAS/RAF/ERK), cell cycle re-entry by quiescent cancer cells, phospholipase A2 and arachidonic acids.

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Selected Publications

Young, L., & Dong, Q. (2010). Targeted amplification of mutant strands for efficient site-directed mutagenesis and mutant screening. Methods in Molecular Biology, 634, 147-155.

Scott, K.F., Sajinovic, M., Hein, J., Nixdorf, S., Galettis, P., Liauw, W., de Souza, P., Dong, Q., Graham, G.G., & Russell, P.J. (2010). Emerging roles for phospholipase A2 enzymes in cancer. Biochimie, 92(6), 601-610.

Assinder, S.J., Au, E., Dong, Q., & Winnick, C. (2010). A novel splice variant of the beta-tropomyosin (TPM2) gene in prostate cancer. Molecular Carcinogenesis, 49(6), 525-531.

Niknami, M., Vignarajan, S., Yao, M., Hua, S., Witting, P.K., Kita, Y., Shimizu, T., Sved, P., & Dong, Q. (2010). Decrease in expression or activity of cytosolic phospholipase A2alpha increases cyclooxygenase-1 action: A cross-talk between key enzymes in arachidonic acid pathway in prostate cancer cells. Biochimica et Biophysica Acta, 1801(7), 731-737.

Singh, J., Xie, C., Yao, M., Hua, S., Vignarajan, S., Jardine, G., Hambly, B.D., & Dong, Q. (2010). Food extracts consumed in Mediterranean countries and East Asia reduce protein concentrations of androgen receptor, phospho-protein kinase B, and phospho-cytosolic phospholipase A(2)alpha in human prostate cancer cells. Journal of Nutrition, 140(4), 786-791.

Yao, M., Taylor, R.A., Richards, M.G., Sved, P., Wong, J., Eisinger, D., Xie, C., Salomon, R., Risbridger, G.P., & Dong, Q. (2010). Prostate-Regenerating Capacity of Cultured Human Adult Prostate Epithelial Cells. Cells, Tissues, Organs, 191(3), 203-212.

Richards, A., McGeechan, K., Niknam, M., Salomon, R., Kurek, C., Dong, Q., & Patel, M.I. (2009). Prolonging androgen sensitivity in prostate cancer - a role for COX inhibitors? ANZ Journal of Surgery, 79(9), 641-647.

Assinder, S.J., Dong, Q., Mangs, H., & Richardson, D.R. (2009). Pharmacological targeting of the integrated protein kinase B, phosphatase and tensin homolog deleted on chromosome 10, and transforming growth factor-beta pathways in prostate cancer. Molecular Pharmacology, 75(3), 429-436.

Assinder, S.J., Dong, Q., Kovacevic, Z., & Richardson, D.R. (2009). The TGF-beta, PI3K/Akt and PTEN pathways: established and proposed biochemical integration in prostate cancer. Biochemical Journal, 417, 411-421.

Niknami, M., Dong, Q., & Witting, P.K. (2009). Pitfalls in the use of arachidonic acid oxidation products to assign lipoxygenase activity in cancer cells. Free Radical Research, 43(10), 951-956.

Niknami, M., Patel, M., Witting, P.K., & Dong, Q. (2009). Molecules in focus: cytosolic phospholipase A2-alpha. [Review]. International Journal of Biochemistry & Cell Biology, 41(5), 994-997.

Salomon, R., Young, L., MacLeod, D., Yu, X.L., & Dong, Q.H. (2009). Probasin Promoter-driven Expression of ID1 Is not Sufficient for Carcinogenesis in Rodent Prostate. Journal of Histochemistry & Cytochemistry, 57(6), 599-604.

Niknami, M., Patel, M., Witting, P., & Dong, Q. (2008). Aberrant activation of arachidonic acid and eicosanoid pathways - targets for treating prostate cancer. Recent patents on Endocrine, Metabolic & Immune Drug Discovery, 2, 9-15.

Patel, M.I., Kurek, C., & Dong, Q. (2008). The arachidonic acid pathway and its role in prostate cancer development and progression. Journal of Urology, 179(5), 1668-1675.

Patel, M.I., Singh, J., Niknami, M., Kurek, C., Yao, M., Lu, S., Maclean, F., Gelb, M.H., Scott, K.F., Russell, P.J., & Dong, Q. (2008). Cytosolic phospholipase A2-alpha: a potential therapeutic target for prostate cancer. Clinical Cancer Research, 14(24), 8070-8079.

Dong, Q., Patel, M., Scott, K.F., Graham, G.G., Russell, P.J., & Sved, P. (2006). Oncogenic action of phospholipase A2 in prostate cancer. Cancer Letters, 240(1), 9-16.

Lim, W.G., Tan, B.J., Zhu, Y.M., Zhou, S.F., Armstrong, J.S., Li, Q.T., Dong, Q., & Duan, W. (2006). The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling. Cellular Signalling, 18(9), 1473-1481.

Singh, J., Manickam, P., Shmoish, M., Natik, S., Denyer, G., Handelsman, D., Gong, D.W., & Dong, Q.H. (2006). Annotation of androgen dependence to human prostate cancer-associated genes by microarray analysis of mouse prostate. Cancer Letters, 237(2), 298-304.

Young, L., Salomon, R., Au, W., Allan, C., Russell, P., & Dong, Q.H. (2006). Ornithine decarboxylase (ODC) expression pattern in human prostate tissues and ODC transgenic mice. Journal of Histochemistry & Cytochemistry, 54(2), 223-229.

Patel, M.I., Tuckerman, R., & Dong, Q. (2005). A Pitfall of the 3-(4,5-dimethylthiazol-2-yl)-5(3-carboxymethonyphenol)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay due to evaporation in wells on the edge of a 96 well plate. Biotechnology Letters, 27(11), 805-808.

Singh, J., Young, L., Handelsman, D.J., & Dong, Q.H.(2005). Molecular cloning and characterization of a novel androgen repressible gene expressed in the prostate epithelium. Gene, 348, 55-63.

Young, L., & Dong, Q. H. (2005). Development of a murine prostatespecific 2-in-1 inducible bicistronic expression vector. Biotechnology Letters, 27(12), 823-828.

Zhu, Y.M., Dong, Q., Tan, B.J., Lim, W.G., Zhou, S.F., & Duan, W. (2005). The PKC alpha-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals. Cancer Research, 65(11), 4520-4524.

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