Doctor Christopher E. Jones

• Biography
• Areas of Research / Teaching Expertise
• Grants / Current Projects
• Awards and Recognition
• Selected Publications
• Optional
• Contact Details

Biography

Education:
1991-1995 Undergraduate(Honours) in Applied Chemistry (Queensland University of Technology)
1998-2002 PhD, The University of Queensland (Chemistry Dept and the National Research Centre for Environmental Toxicology, EnTox)

Work:
1993 Analytical Chemist, Baxter Healthcare, Toongabbie, NSW
1996-1998 Scientist, Department of Clinical Pharmacology, The Princess Alexandra Hospital, Brisbane, Australia.
2002-2005 Postdoctoral Fellow, Queen Mary College, The University of London, London
2005-2009 Research Fellow, School of Chemistry and Molecular Biosciences (SCMB)
2010 - Lecturer in Biochemistry, The University of Western Sydney. Honorary Research Consultant,The University of Queensland, SCMB.

^ Back to top

Areas of Research / Teaching Expertise

Bioinorganic Chemistry
Protein Biochemistry
Chemical Biology
Metalloneurochemistry

^ Back to top

Grants / Current Projects

Current projects:

• Role of the prion protein in the copper dependent regulation of iron in the brain.

• Redox activity of the prion protein -physiological relevance of copper(I) and copper(II) coordination.

• Immunosuppressants and metals: using coordination complexes of mycophenolic acid to limit gastrointestinal adverse effects and improve efficacy.

Grants:

2007 Early Career Researcher Grant - University of Queensland
"Inhibition of gastrointestinal adverse events associated with Mycophenolic acid use: A novel use for copper."

^ Back to top

Awards and Recognition

2007-2009 University of Queensland Research Fellowship
2003-2007 CJ Martin Postdoctoral Fellowship, National Health and Medical Research Council, Australia.
1999-2000 Alfred and Olivea Wynne Memorial Scholarship.
1998-2001 Dora Lush (Biomedical) Postgraduate Research Scholarship, National Health and Medical Research Council, Australia.
1995 Queensland University of Technology, Centre for
Instrumental and Developmental Chemistry Honours Bursary.
1994 Australian Laboratory Services Pty Ltd Prize for
Analytical Chemistry.

^ Back to top

Selected Publications

Journal Articles

Badrick AC and Jones CE.* The amyloidogenic region of the human Prion protein contains a high affinity (His)2(Met)2 Cu(I) binding site. J. Inorg. Biochem. 103(8), 1169-75, 2009.

Badrick AC, Hanson GR and Jones CE.* Chaperoning the immunosuppressant Mycophenolic acid through the gastrointestinal tract: a role for copper. App. Magn. Reson. 36 (2-4), 231-236, 2009.

O’Sullivan DBD^, Jones CE^, Abdelraheim SR, Brazier MW, Toms H, Brown DR and Viles JH. Dynamics of a truncated prion protein, PrP(113-231) from 15N NMR relaxation. Order parameters calculated and slow conformational fluctuations localized to a distinct region. Protein Science, 18(2):410-423, 2009.

Lim KHL, Jones CE, vanden Hoven RN, Edwards JL, Falsetta M, Apicella MA, Jennings MP and McEwan AG. Metal binding specificity of the MntABC permease of Neisseria gonorrhoeae and its influence on bacterial growth and interaction with cervical epithelial cells. Infect. Immun. 76(8), 3569-3576, 2008.

Badrick AC and Jones CE.* The immunosuppressive drug Mycophenolic Acid does not bind iron(II) under conditions mimicking the upper gastrointestinal environment. Transplantation. 84(6), 799-800, 2007

Jones CE*, Underwood CK, Coulson EJ and Taylor PJ. Copper induced oxidation of serotonin: analysis of products and toxicity. J. Neurochem. 102(4), 1035-1043, 2007.

Jones CE*, Taylor PJ, McEwan A and Hanson GR. Spectroscopic analysis of copper binding to the immunosuppressive drug mycophenolic acid. J. Am. Chem. Soc. 128(29), 9378-9386, 2006.

Jones CE, Klewpatinond M, Abdelraheim SR, Brown DR and Viles JH. Probing copper2+ binding to the prion protein using diamagnetic nickel2+ and 1H NMR: six Cu2+ ions bind at physiological concentrations. J. Mol. Biol., 346, 1393-1407, 2005.

Jones CE, Abdelraheim SR, Brown DR and Viles JH. Preferential copper2+ coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein. J. Biol. Chem, 279 (31), 32018-27, 2004.

Reviews

Badrick AC and Jones CE. Reorganising metals: the use of chelating compounds as potential therapies for metal-related neurodegenerative diseases. Curr. Med. Chem., accepted, 2010.

Badrick AC and Jones CE. Metal Minded: Use, control and metallic interplay of copper in the brain. Horizons in Neuroscience Research (Vol 2). Ed: Andres Costa and Eugenio Villalba. Nova Science Publishers, Hauppauge, NY, USA. 2010. ISBN: 978-1-60876-876-9

^ Back to top

Optional

Member:
Society for Biological Inorganic Chemistry

^ Back to top