Professor Bill Price

• Qualifications
• Biography
• Research
• Selected Publications
• Grants/Current Projects
• Teaching
• Awards/Honours 
• Professional Activities 

Qualifications

PhD, BSc(Hons) Syd

Biography

Professor William (Bill) S. Price completed both undergraduate and graduate studies at the University of Sydney. He completed his PhD in 1990. His PhD work was on the development of experimental and theoretical approaches for measuring diffusion, viscosity, transport and binding of small molecules in human red blood cells using nuclear magnetic resonance (NMR) spectroscopy. His supervisors were Professor Philip W. Kuchel and Dr. Bruce A. Cornell.

Professor Price's first postdoctoral position was at the Institute of Atomic and Molecular Science (IAMS) founded by the Nobel Laureate, Y. T. Lee in Taipei, Taiwan 1990-1993 with Professor Lian-Pin Hwang. At IAMS he developed advanced nuclear magnetic NMR relaxation techniques for studying molecular dynamics and also collaborated with the largest hospital in Taipei on clinical studies (hypothermia and pleural effusions).

His second postdoctoral position (1993-1995) was at the National Institute of Advanced Industrial Science and Technology in Japan with Prof. Kikuko Hayamizu where he investigated and developed sophisticated solid-state deuterium NMR techniques for investigating polymerization as part of a national project on the development of non-linear optical polymers. During this time Professor Price also collaborated with the Himeji Institute of Technology on the effects of hydration on phenyl ring dynamics in human insulin.

Professor Price currently holds the chair of nanotechnology in the School of Science and Health and the School of Medicine at the University of Western Sydney (UWS). He is the director of the Biomedical Magnetic Resonance Facility and director of the UWS node of the National Imaging Facility and he is an Adjunct Professor at the National Wine and Grape Industry Centre at Charles Sturt University. He leads the Nanoscale Organisation and Dynamics Research Group at UWS.

Research scientist, Water Research Institute, Tsukuba, Japan (1995 -1996).
Chief scientist, Water Research Institute, Tsukuba, Japan (1996 - 1999).
Senior visiting scientist, Royal Institute of Technology, Stockholm, Sweden (2000 - 2001).
Professor of Chemistry, Tokyo Metropolitan University, Tokyo, Japan (2001 – 2003).

See also www.uws.edu.au/nmr

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Research

Professor Price’s research interests span the areas of physics, chemistry and biology relevant to Medical Nanotechnology. He is an expert in the theory, development and application of nuclear magnetic resonance (NMR) spectroscopy with particular emphasis on NMR diffusion measurements and magnetic resonance imaging (MRI) techniques for studying molecular association and molecular dynamics, especially in the development of new NMR techniques, molecular dynamics in biological and chemical systems using NMR imaging, relaxation and pulsed gradient spin-echo NMR measurements of translational diffusion. Prof. Price’s research has direct applications to a wide range of practical problems including pharmaceutical screening and lithium batteries.

Current areas of research include:

• Molecular mechanisms of ionic conduction (e.g., in lithium battery electrolytes). 
• Protein association and crystallisation. 
  
• Effects of macromolecular crowding on molecular association.
• Theoretical/experimental studies of restricted diffusion in porous media.
  
• Solution dynamics and self-association in aqueous solutions.
  
• Development of sophisticated NMR and MRI techniques for studying molecular dynamics.

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Selected Publications

Books - as Author

Price, W.S. (2009). NMR Studies of Translational Motion. Cambridge University Press. ISBN-13: 9780521806961.

Books - as Editor

Elyashberg, M.E., Williams, A., Blinov, K. (2011). Royal Society of Chemistry, Price.W.S. (Editor-in-Chief of the Series). New Development in NMR. Series of Books published by the Royal Society of Chemistry ISBN-13: 978-1849734325

BOOKS - Chapters

Yadav, N., Stait-Gardner, T., and Price, W.S. (2011). Hardware Considerations for Diffusion MRI in Diffusion MRI - Theory, Methods and Applications (Ed. Jones, D.K.). Oxford University Press. pp 171-181. ISBN-13: 978-01953697791.

Torres, A., Price, W. (2011). Chapter 5: Introduction to Nuclear Magnetic Resonance in Metallointercalators: Synthesis and Techniques to Probe their Interactions with Biomolecules. (Ed Prof Janice R. Aldrich-Wright). New York, pp 129-141. ISBN-13:978-32111094273.

Zheng, G., Krause-Heuer, K., Price, W. (2011). Chapter 7; Pulsed Gradient Spin-Echo NMR in Metallointercalators: Synthesis and Techniques to Probe their Interactions with Biomolecules, (Ed Prof Janice R. Aldrich-Wright). USA, pp 159-185. ISBN-13:978-3211094273.

Publications

Bourne, R.M., Kurniawan, N., Cowin, G., Stait-Gardner, T., Sved, P., Watson, G., Chowdhury, S., Price, W.S. (2012). Biexponential diffusion decay in formalin-fixed prostate tissue: Preliminary findings. Magnetic Resonance in Medicine. In press. DOI:10.1002/mrm.23291.

Bourne, R.M., Kurniawan, N., Cowin, G., Stait-Gardner, T., Sved, P., Watson, G., Price, W.S. (2012). Microscopic diffusivity compartmentation in formalin-fixed prostate tissue. Magnetic Resonance in Medicine. In press. DOI:10.1002/mrm.23244.

Zheng, G., Price, W.S. (2012). Direct Hydrodynamic Radius Measurement on Dissolved Organic Matter in Natural Waters Using Diffusion NMR. Environmental Science & Technology, 46(3), 1675-1680. DOI:10.1021/es202809e.

Da Costa, V.C.P., Ribeiro, A.C.F., Sobral, A.J.F.N., Lobo, V.M.M., Annunziata, O., Santos, C.I.A.V., Willis, S.A., Price, W.S., Esteso, M.A. (2012). Mutual and self-diffusion of charged porphyrines in aqueous solutions. Journal of Chemical Thermodynamics 47, 312-319. DOI:10.1016/j.jct.2011.11.006.

Ghadirian, B., Stait-Gardner, T., Hennessy, A., Price, W.S. (2011). Energy Dissipation in Porous Media for Equilibrium and Non-equilibrium Translational Motions. Diffusion Fundamentals, 15(1), 1-21.

Zheng, G., Torres, A., Ali, M., Manolios, N., Price, W.S. (2011). NMR study of structure and self-association of core peptide in aqueous solution and DPC micelles. Biopolymers (Pept. Sci.), 96(2), 177-180. DOI:10.1002/bip.21423.

Torres, A., Zheng, G., Price, W,.S. (2010). J-compensated PGSE: an improved NMR diffusion experiment with fewer phase distortions. Magnetic Resonance in Chemistry, 48, 129-133. DOI:10.1002/mrc.2555.

Zheng, G., Price, W.S. (2010). Solvent signal suppression in NMR. Progress in Nuclear Magnetic Resonance Spectroscopy, 56, 267-288. DOI:10.1016/j.pnmrs.2010.01.001.

Price, W.S., Stait-Gardner, T., Torres, A., Zheng, G. (2010). Developments in NMR Diffusion Measurements and q-space Imaging. Chinese Journal of Magnetic Resonance, 27(3), 267-288. DOI:CNKI:SUN:PPXZ.0.2010-03-000.

Willis, S., Dennis, G., Zheng, G., Price, W.S. (2010). Averaging Effects in PGSE NMR Attenuations Observed in Bimodal Molecular Weight PMMA Solutions. Macromolecules, 43, 7351-7356. DOI:10.1021/ma1017007.

Soderman, O., Price, W.S., Schonhoff, M., Topgaard, D. (2010). NMR diffusometry applied to liquids. Journal of Molecular Liquids, 156, 38-44 DOI:10.1016/j.molliq.2010.05.007.

Willis, S., Dennis, G., Zheng, G., Price, W.S. (2010). Hydrodynamic size and scaling relations for linear and 4 arm star PVAc studied using PGSE NMR. Journal of Molecular Liquids, 156, 45-51.  DOI:10.1016/j.molliq.2010.04.026.

Ghadirian, B., Stait-Gardner, T., Castillo, R., Price, W.S. (2010). Modelling diffusion in restricted systems using the heat kernel expansion. Journal of Chemical Physics, 132(23), 234108. DOI:234108 10.1063/1.3451124.

Sims, A., Stait-Gardner, T., Fong, L., Morley, J., Price, W.S., Hoffman, M., Simmons, A., Schindhelm, J. (2010). Elastic and viscoelastic properties of porcine subdermal fat using MRI and inverse FEA. Biomech Model Mechanobiol, 9(6), 703-711. DOI:10.1007/s10237-010-0207-9.

Yadav, N., Torres, A., Price, W.S. (2010). NMR q-space imaging of macroscopic pores using singlet spin states. Journal of Magnetic Resonance, 204(2), 346-348. DOI:10.1016/j.jmr.2010.03.010.

Zheng, G., Torres, A., Price, W.S. (2009). MQ-PGSTE: a new multi-quantum STE-based PGSE NMR sequence. Journal of Magnetic Resonance, 198, 271-274. DOI:10.1016/j.jmr.2009.03.004.

Yadav, N., Price, W.S. (2009). Impediments to the accurate structural characterisation of a highly concentrated emulsion studied using NMR diffusion diffraction. Journal of Colloid and Interface Science, 338, 163-168 DOI:10.1016/j.jcis.2009.06.014.

Zheng, G., Price, W.S. (2009). Simultaneous convection compensation and solvent suppression in biomolecular NMR diffusion experiments. Journal of Biomolecular Chemistry, 45, 295-299. DOI:10.1007/s10858-009-9367-2.

Stait-Gardner, T., Willis, S., Yadav, N., Zheng, G., Price, W.S. (2009). NMR Diffusion Measurements of Complex Systems. Diffusion Fundamentals, 15, 1-22.

Stait-Gardner, T., Price, W.S. (2009). A Physical Interpretation of Product Operator Terms. Concepts of Magnetic Resonance Part A, 34A(6), 322-356 DOI:10.1002/cmr.a.20151.

Krause-Heuer, A.M., Wheate, N.J., Price, W.S., Aldrich-Wright, J.R. (2009). Diffusion-based studies on the self-stacking and nanorod formation of platinum(II) intercalators. Chem. Comm. 9 1210-1212. DOI:10.1039/b820584a.

Price, W.S. (2008). NMR Studies of Translational Motion. Cambridge University Press. ISBN-13: 9780521806961.

Yadav, N.N., Stait-Gardner, T., Price, W.S. (2008). Hardware considerations for Diffusion MRI. Diffusion MRI (D. Jones, Ed.), Oxford University Press. ISBN-13: 978-0195369779.

Wheate, N.J., Anil Kumar, P.G., Torres, A.M., Aldrich-Wright, J.R., Price, W.S. (2008). Examination of cucurbit[7]uril and its host-guest complexes by diffusion NMR. J.Phys. Chem. B. 112, 2311-2314. DOI:10.1021/jp709847p.

Zheng, G., Stait-Gardner, T., Anil Kumar, P.G., Torres, A.M., Price, W.S. (2008). PGSTE-WATERGATE: An STE-based PGSE NMR sequence with excellent solvent suppression. J. Magn. Reson. 191, 159-163. DOI:10.1016/j.jmr.2007.12.001.

Torres, A.M., Dela Cruz, R., Price, W.S. (2008). Removal of J-coupling peak distortion in PGSE experiments. J. Magn. Reson. 193, 311-316. DOI:10.1016/j.jmr.2008.05.006.

Yadav, N.N., Torres, A.M., Price, W.S. (2008). An improved approach to calibrating high magnetic field gradients for pulsed field gradient experiments. J. Magn. Reson. 194, 25-28. DOI:10.1016/j.jmr.2008.05.015.

Zheng, G., Torres, A.M., Price, W.S. (2008). Solvent suppression using phase-modulated binomial sequences and applications to diffusion measurements. J. Magn. Reson. 194, 108-114. DOI:10.1016/j.jmr.2008.06.004.

Stait-Gardner, T., Anil Kumar, P.G., Torres, A.M., Price, W.S., (2008) Steady state effects in PGSE NMR diffusion experiments. Chem. Phys. Lett. 462, 331-336. DOI:10.1016/j.cplett.2008.07.084.

Zheng, G., Price, W.S. (2008). MAG-PGSTE: a new STE-based PGSE NMR sequence for the determination of diffusion in magnetically inhomogeneous samples. J .Magn. Reson. 195, 40-44. DOI:10.1016/j.jmr.2009.03.004.

Price, W.S., Hallberg, F., Stilbs, P. (2007). A PGSE diffusion and electrophoretic NMR study of Cs+ and Na+ dynamics in aqueous crown ether systems. Magn. Reson. Chem. 45, 152-156. DOI:10.1002/mrc.1936.

Still, B.M., Anil Kumar, P.G., Aldrich-Wright, J.R., Price, W.S. (2007). 195Pt theory and application. Chem. Soc. Rev. 36, 665-686. DOI:10.1039/b606190g.

Zheng, G., Price, W.S. (2007). Suppression of background gradients in (B0 gradient-based) NMR diffusion experiments. Concepts in Magn. Reson. 30A, 261-277. DOI:10.1002/cmr.a.20092.

Traytak, S.D., Price, W.S. (2007). Exact solution for anisotropic diffusion-controlled reactions with partially reflective conditions. J. Chem. Phys. 18, 184508-1-184508-8. DOI:184508 10.1063/1.2786452.

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Current/Grants Projects

Research funding from Australian Research Council, NSW State Governtment, Cancer Institute of NSW, UWS.

Teaching

Professor Price presents lectures in the BMedSci(Nanotechnology) program.

He also supervises Honours and Postgraduate students as well as teaching paper and thesis writing.

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Awards/Honours

The Archibald D. Ollé Prize for the "best treatise, writing or paper" on any subject relevant to the Institute's interests, awarded by the Royal Australian Chemical Institute (2011).

Vice Chancellor’s Awards for Excellence in Postgraduate Research, Training and Supervision (2010) – Highly Commended.

Ollé Prize for Chemical Literature, Royal Australian Chemical Institute (1999 & 2010). http://en.wikipedia.org/wiki/Oll%C3%A9_Prize.

BioFirst Award, NSW State Government (2004).

Fellow of the Royal Society of Chemistry (2000).

Senior Visiting Scientist, Royal Institute of Technology, Stockholm, Sweden (Senior Fellowship, Swedish Council for International Cooperation in Research and Higher Education) (2000).

RACI RSC Corday Morgan – Rennie Medal Exchange Lecturer (1999).

Fellow of the Royal Australian Chemical Institute (1999).

Rennie Memorial Medal (National Medal), Royal Australian Chemical Institute (1998).
http://en.wikipedia.org/wiki/Rennie_Memorial_Medal

The Science and Technology Agency Fellowship, Australian Academy of Science/Japanese Government (1993-1995).

The Charles Gilbert Heydon Travelling Fellowship in the Biological Sciences, University of Sydney (1991-1992).

The Eleanor Sophia Wood Travelling Fellowship, University of Sydney (1991).

Postdoctoral Fellowship, National Science Council, Republic of China (1990-1993).

Commonwealth Postgraduate Research Award (1986-1989).

Fellowships

• Royal Australian Chemical Institute from 1999
• Royal Society of Chemistry from 2000

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Professional Activities

Professor Price is a member of the following societies:

• American Biophysical Society (since 1986)
• Australian and New Zealand Society for Magnetic Resonance (ANZMAG) (Since 2000)
• Australian Society for Biochemistry and Molecular Biology Inc (Since 1985)
• Australian Society for Biophysics (Since 1986)
• Chinese Chemical Society (Taiwan), (1991 - life member)
• Royal Australian Chemical Institute (Since 1993)
• Royal Society of Chemistry (Since 2000)
• Conjoint  Professor, School of Medicine, University of Western Sydney
• Adjunct  Professor, National Wine and Grape Industry Centre, Charles Sturt University
• Group Leader, UWS Nanoscale Organisation and Dynamics Research Group, University of Western Sydney
• Director of the UWS Node of the National Imaging Facility (www.anif.org.au)
• Director of the UWS Biomedical Magnetic Resonance Facility

Professor Price is on the Editorial board of:

Concepts in Magnetic Resonance (since 2000)

Diffusion Fundamentals (since 2003)

Journal Of Chemical Biology (since 2008)

The Open Chemical Physics Journal (since 2007)

The Open Magnetic Resonance Journal (since 2007)

Professor Price is the Editor-in-Chief of the The Royal Society of Chemistry’s “New Developments in NMR” Book Series (http://www.rsc.org/shop/books/series/91.asp?seriesid=91). He regularly reviews grant applications for the Australian Research Council and other domestic and international granting bodies.

Professor Price also presents lectures to public groups, schools and other institutions on a regular basis.

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