Doctor Bjorn Espedido
SCIENTIFIC OFFICER,
School of Medicine
Personal
Qualifications
- PhD University of Sydney
- BSc University of Technology, Sydney
- BSc University of Technology, Sydney
UWS Organisational Unit (School / Division)
- School of Medicine
Contact
| Email: | B.Espedido@uws.edu.au |
|---|---|
| Extension: | (02) 8738 9017 |
| Mobile: | |
| Location: | Off Campus |
| Website: |
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Biography
Dr Bjorn Espedido is a Post-doctoral Scientific Officer in the Antibiotic Resistance & Mobile Elements Group (ARMEG), based in the Infectious Diseases & Microbiology Unit, University of Western Sydney School of Medicine. His research interests are in the area of molecular bacteriology with a primary focus on the genetic mechanisms of antibiotic resistance. During his PhD he detected and characterised the genetic context of a carbapenem resistance gene (blaIMP-4) previously not seen in Australia. Furthermore, he examined the balance between carbapenem hydrolysis and outer membrane permeability defects in conferring antibiotic resistance in the Enterobacteriaceae. Dr Espedido is currently working on understanding the genetic mechanisms behind antibiotic resistance and its spread in Staphylococcus aureus. Comparative whole genome approaches are being used to examine the impact of antibiotics on the evolution of clinical S. aureus strains and to identify genetic determinants that confer not only antibiotic resistance but also increased virulence. Additionally, he is interested in plasmid partitioning systems in S. aureus with a view to understanding the biology of these mobile elements that play an important role in the spread of antibiotic resistance.
This information has been contributed by Doctor Espedido.
Publications
Journal Articles
- Espedido, B. and Gosbell, I. (2012), 'Chromosomal mutations involved in antibiotic resistance in Staphylococcus aureus.', Frontiers in Bioscience (Scholar Edition), 16.
- Van Hal, S., Jensen, S., Vaska, V., Espedido, B., Paterson, D. and Gosbell, I. (2012), 'Predictors of Mortality in Staphylococcus aureus Bacteremia.', Clinical Microbiology Reviews, 25.
- Espedido, B. and Gosbell, I. (2012), 'Chromosomal mutations involved in antibiotic resistance in Staphylococcus aureus', Frontiers in Bioscience (Scholar Edition), 16.
- Van Hal, S., Jensen, S., Vaska, V., Espedido, B., Paterson, D. and Gosbell, I. (2012), 'Predictors of mortality in Staphylococcus aureus bacteremia', Clinical Microbiology Reviews, 25.
- Espedido, B., Espedido, B., Jensen, S., Jensen, S., Steen, J., Barbagiannakos, T., Mercer, J., Paterson, D., Grimmond, S., Cooper, M., Gosbell, I., Gosbell, I. and Van Hal, S. (2012), 'Carriage of an ACME II variant may have contributed to methicillin- resistant Staphylococcus aureus sequence type 239-like strain replacement in Liverpool Hospital, Sydney, Australia', Antimicrobial Agents and Chemotherapy, 4.
- Jiang, X., Espedido, B., Partridge, S., Thomas, L., Wang, F. and Iredell, J. (2009), 'Paradoxical effect of Klebsiella pneumoniae OmpK36 porin deficiency', Pathology, 5.
- Van Hal, S., Wiklendt, A., Espedido, B., Ginn, A. and Iredell, J. (2009), 'Immediate Appearance of Plasmid-Mediated Resistance to Multiple Antibiotics upon Antibiotic Selection: an Argument for Systematic Resistance Epidemiology', Journal of Clinical Microbiology, 3.
- Espedido, B., Partridge, S. and Iredell, J. (2008), 'blaIMP-4 in Different Genetic Contexts in Enterobacteriaceae Isolates from Australia', Antimicrobial Agents and Chemotherapy, 4.
- Espedido, B., Thomas, L. and Iredell, J. (2007), 'Metallo-?-Lactamase or Extended-Spectrum ?-Lactamase: a Wolf in Sheep's Clothing', Journal of Clinical Microbiology, 3.
- Iredell, J., Thomas, L. and Espedido, B. (2006), '?-lactam resistance in the Gram-negatives: Increasing complexity of conditional, composite and multiply resistant phenotypes', Pathology, 9.
Conference Papers
- Espedido, B., McDonald, K., Martin, D., Dhabbi, J., Suter, C. and Buckland, M. (2009), 'Using genome-wide methylation mapping to find oligodendroglial tumour suppressor genes', Australian and New Zealand Society for Neuropathology Annual Scientific Meeting, St. Vincent?s Centre for Applied Medical Research.
- Buckland, M., Stankovic, R., McDonald, K., Martin, D., Dhabbi, J. and Espedido, B. (2009), 'Peptidylarginine deiminase 2 (PADI2) on 1p36.13 is frequently hypermethylated in oligodendrogliomas: A candidate tumour suppressor gene', Australian and New Zealand Society for Neuropathology Annual Scientific Meeting, St. Vincent?s Centre for Applied Medical Research.
- Espedido, B., Partridge, S. and Iredell, J. (2007), 'Failure to detect multi-drug resistant Pseudomonas aeruginosa producing IMP-4 by conventional EDTA-synergy-based tests in Australia', Interscience Conference on Antimicrobial Agents and Chemotherapy, Centre for Infectious Diseases & Microbiology, University of Sydney.
- Espedido, B., Partridge, S. and Iredell, J. (2006), 'The genetic context of blaIMP-4 in Australia', Interscience Conference on Antimicrobial Agents and Chemotherapy, Centre for Infectious Diseases & Microbiology, University of Sydney.
