Doctor Colin Stack

Journal Articles

• Cronin, L., Moffitt, M., Mawad, D., Morton, O., Lauto, A. and Stack, C. (2013), 'An in vitro study of the photodynamic effect of rose bengal on Trichophyton rubrum.', Journal of Biophotonics, .
• Sun, Z., Stack, C. and Slapeta, J. (2012), 'Sequence differences in the diagnostic region of the cysteine protease 8 gene of Tritrichomonas foetus parasites of cats and cattle.', Veterinary Parasitology, 5.
• Skinner-Adams, T., Peaty, C., Anderson, K., Trenholme, K., Kridge, D., Brown, C., Stack, C. and Nsangou, D. (2012), 'The Aminopeptidase Inhibitor CHR-2863 Is an Orally Bioavailable Inhibitor of Murine Malaria.', Antimicrobial Agents and Chemotherapy, 6.
• Slapeta, J., Muller, N., Stack, C., Walker, G., Lew-Tabor, A., Tachezy, J. and Frey, C. (2012), 'Comparative analysis of Tritrichomonas foetus (Riedmuller, 1928) cat genotype, T. foetus (Riedmuller, 1928) cattle genotype and Tritrichomonas suis (Davaine, 1875) at 10 DNA loci', International Journal for Parasitology, 7.
• Thiverge, K., Gardiner, D., Dalton, J., Mathew, R., Nsangou, D., Da Silva, F., Cotton, S., Skinner- Adams, T., Trenholme, K., Stack, C., Brown, C. and Stack, C. (2012), 'Anti-malaria drug development targeting the M1 alanyl and M17 leucyl aminopeptidases', ARKIVOC, 17.
• Thiverge, K., Gardiner, D., Dalton, J., Mathew, R., Nsangou, D., Da Silva, F., Cotton, S., Skinner- Adams, T., Trenholme, K., Stack, C., Brown, C. and Stack, C. (2012), 'Anti-malaria drug development targeting the M1 alanyl and M17 leucyl aminopeptidases', ARKIVOC, 17.
• Sun, Z., Stack, C. and Slapeta, J. (2012), 'Sequence differences in the diagnostic region of the cysteine protease 8 gene of Tritrichomonas foetus parasites of cats and cattle', Veterinary Parasitology, 5.
• Sun, Z., Stack, C. and Slapeta, J. (2012), 'Sequence differences in the diagnostic region of the cysteine protease 8 gene of Tritrichomonas foetus parasites of cats and cattle', Veterinary Parasitology, 5.
• Skinner-Adams, T., Thivierge, K., Dalton, J., Gardiner, D., Peatey, C., Anderson, K., Trenholme, K., Krige, D., Brown, C., Stack, C., Nsangou, D. and Mathews, R. (2012), 'The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria', Antimicrobial Agents and Chemotherapy, 6.
• Slapeta, J., Mu?ller, N., Stack, C., Walker, G., Lew-Tabor, A., Tachezy, J. and Frey, C. (2012), 'Comparative analysis of Tritrichomonas foetus (Riedmuller, 1928) cat genotype, T. foetus (Riedmuller, 1928) cattle genotype and Tritrichomonas suis (Davaine, 1875) at 10 DNA loci', International Journal for Parasitology, 7.
• Thiverge, K., Gardiner, D., Dalton, J., Mathew, R., Nsangou, D., Silva, F., Cotton, S., Skinner- Adams, T., Trenholme, K., Brown, C. and Stack, C. (2012), 'Anti-malaria drug development targeting the M1 alanyl and M17 leucyl aminopeptidases', ARKIVOC, 17.
• Stack, C., Stack, C., Dalton, J. and Robinson, M. (2011), 'The phylogeny, structure and function of trematode cysteine proteases, with particular emphasis on the Fasciola hepatica cathepsin L family', Advances in Experimental Medicine and Biology, 20.
• Skinner-Adams, T., McGowan, S., Whisstock, J., Gardiner, D., Dalton, J., Stack, C., Trenholme, K., Brown, C., Grembecka, J., Lowther, J., Mucha, A., Drag, M. and Kafarski, P. (2010), 'Plasmodium flaciparum neutral aminopeptidases: new targets for anti-malarials', Trends in Biochemical Sciences, 9.
• Mcgowan, S., Grembecka, J., Trenholme, K., Buckle, A., Gardiner, D., Dalton, J., Whisstock, J., Oellig, C., Birru, W., Caradoc-Davies, T., Stack, C., Lowther, J., Skinner-Adasm, T., Mucha, A. and Kafarski, P. (2010), 'Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.', Proceedings of National Academy of Science, 6.
• Trenholme, K., Gardiner, D., Brown, C., Skinner-Adams, T., Stack, C., Lowther, J., To, J., Robinson, M., Donnelly, S. and Dalton, J. (2010), 'Aminopeptidases of malaria parasites: New targets for chemotherapy', Infectious Disorders - Drug Targets, 9.
• Donnelly, S., O'Neil, S., Stack, C., Robinson, M., Turnbull, L., Whitchurch, C. and Dalton, J. (2010), 'Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3', Journal of Biological Chemistry, 10.
• Golden, O., Flynn, R., Read, C., Sekiya, M., Donnelly, S., Stack, C. and Dalton, J. (2010), 'Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1).', Vaccine, 7.
• Lowther, J., Robinson, M., Donelly, S., Xu, W., Stack, C., Matthews, J. and Dalton, J. (2009), 'The Importance of pH in Regulating the Function of the Fasciola hepatica Cathepsin L1 Cysteine Protease', PLoA Neglected Tropical Diseases, .
• Mcgowan, S., Grembecka, J., Mucha, A., Kafarski, P., DeGori, R., Buckle, A., Gardiner, D., Whisstock, J., Dalton, J., Porter, C., Lowther, J., Stack, C., Golding, S., Skinner-Adams, T., Trenholme, K., Teuscher, F. and Donnelly, S. (2009), 'Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase', Proceedings National Academy of Science, 6.
• Maric, S., Donnelly, S., Robinson, M., Skinner-Adams, T., Trenholme, K., Gardiner, D., Dalton, J., Stack, C. and Lowther, J. (2009), 'The M17 Leucine Aminopeptidase of the Malaria parasite Plasmodium falciparum: Importance of active site metal ions in the binding of substrates and inhibitors', Biochemistry, 5.
• Donnelly, S., O'Neill, S., Stack, C., Robinson, M., Turnbull, L., Whitxhurch, C. and Dalton, J. (2009), 'Helminth cysteine proteases inhibit Trif-dependant activation of Macrophages via degredation of TLR3', Journal of Biological Chemistry, .
• Gardiner, D., Skinner-Adams, T., Brown, C., Andrews, K., Stack, C., Mccarthy, J., Dalton, J. and Trenholme, K. (2009), 'Plasmodium falciparum: new molecular targets with potential for anitmalarial drug development', Expert Review of Anti-infective Therapy, 12.
• Donnelly, S., Stack, C., O'Neill, S., Sayed, A., Williams, D. and Dalton, J. (2008), 'Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages.', The FASEB Journal, 11.
• Robinson, M., Tort, J., Lowther, J., Donnelly, S., Wong, E. and Stack, C. (2008), 'Proteomics and Phylogenetic analysis of the Cathepepsin L Protease family of the Helminth pathogen Fasciola hepatic', Molecular & Cellular Proteomics, 13.
• Stack, C., McKerrow, J., Craik, C., Geiger, S., Marion, R., Brinen, L., Dalton, J., Caffrey, C., Donnelly, S., Seshaadri, A., Lowther, J., Tort, J., Collins, P., Robinson, M. and Xu, W. (2008), 'Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica', Journal of Biological Chemistry, 13.
• Skinner-Adams, T., Lowther, J., Treuscher, F., Stack, C., Grembecka, J., Mucha, A. and + 4 Externals, . (2007), 'Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 aminopeptidase as lead anti-malarial compounds.', Journal of Medicinal chemistry, 8.
• Treuscher, F., Lowther, J., Skinner-Adams, T., Speilmann, T., Dixon, M., Stack, C. and + 7 Externals, . (2007), 'The M18 Aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.', Journal of Biological Chemistry, 10.
• Kanaji, S., Tanaka, Y., Sakata, Y., Takeshita, K., Arima, K., Stack, C., Ohta, S. and + 6 Externals, . (2007), 'Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases', FEBS Letters, 5.
• Stack, C., Donnelly, S., Lowther, J., Wu, D., Collins, P., Brinen, L. and Dalton, J. (2007), 'The Major Secreted Cathepsin L protease of the liver fluke, Fasciola hepatica: A LEU-12 to PRO-12 replacement in the non-conserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular...', Journal of Biological Chemistry, 12.
• Doleckova, K., Kasny, M., Mikes, L., Mutapi, F., Stack, C., Mountford, A. and Horak, P. (2007), 'Peptidases of Trichobilharzia regenti (Schistosomatidae) and its molluscan host Radix peregra s. lat. (Lymnaeidae): construction and screening of cDNA library from intramolluscan stages of the parasite', Folia Parasitologica, 5.
• Stack, C., Lowther, J., Cunningham, E., Donnelly, S., Gardiner, D., Trenholme, K., Skinner-Adams, T. and + 7 Externals, . (2007), 'Characterisation of the Plasmodium falciparum M17 leucyl aminopeptidase: A protease involved in amino acid regulation with potential for antimalarial drug development', Journal of Biological Chemistry, 12.
• Sekiya, M., Mulcahy, G., Irwin, J., Stack, C., Donnelly, S., Xu, W., Collins, P. and Dalton, J. (2006), 'Biochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepatica', FEBS Letters, 7.
• Gardiner, D., Trenholme, K., Skinner-Adams, T., Stack, C. and Dalton, J. (2006), 'Over-expression of leucyl aminopeptidase in Plasmodium falciparum parasites: Target for the anti-malarial activity of bestatin', Journal of Biological Chemistry, 5.
• Stack, C., Dalton, J., Cunneen, M. and Donnelly, S. (2005), 'De-glycosylation of Pichia pastoris-produced Schistosoma mansoni cathepsin B eliminates non-specific reactivity with IgG in normal human serum', Journal of Immunological Methods, 7.
• Collins, P., Stack, C., O'Neill, S., Doyle, S., Thecla, T., Brennan, G., Mousley, A. and + 4 Externals, . (2004), 'Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence - Propeptide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells', Journal of Biological Chemistry, 9.
• Mccarthy, E., Stack, C., Donnelly, S., Doyle, S., Mann, V., Brindley, P., Stewart, M. and + 3 Externals, . (2004), 'Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicum', International journal for Parasitology, 12.
• Dalton, J., Neill, S., Stack, C., Collins, P., Walshe, A., Sekiya, M., Doyle, S. and + 9 Externals, . (2003), 'Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines', International journal for Parasitology, 9.
• O'Leary, S., Power, A., Stack, C. and Burnell, A. (2001), 'Behavioural and physiological responses of infective juveniles of the entomopathogenic nematode Heterorhabditis to desiccation', BioControl, 18.