Doctor Dennis Chang
DIRECTOR, RESEARCH,
Dean's Unit - School of Science and Health
ASSOCIATE PROFESSOR,
Centre for Complementary Medicine Research
Personal
Qualifications
- MSc University of Sydney
- PhD University of Sydney
UWS Organisational Unit (School / Division)
- Dean's Unit - School of Science and Health
- Centre for Complementary Medicine Research
Contact
| Email: | D.Chang@uws.edu.au |
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| Extension: | 3920 |
| Mobile: | |
| Location: | 5.LG.26 Campbelltown |
| Website: |
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Biography
Associate Professor Dennis Chang is currently the Leader of Clincal Program at UWS CompleMED and Associate Head of School, School of Biomedical and Health Sciences. Since joining UWS, A/Prof Chang has developed a strong research agenda in complementary medicine. His research interests largely focus on clinical trials and pharmacokinetics and pharmacodynamic studies of herbal medicines for the management of cardiovascular (e.g. metabolic syndrome and diabetes) and neurodegenerative diseases (e.g. vascular dementia). He has recently established a clinical laboratory specialising in assessing complementary medicine effects on cognitive and cardiovascular functions. He has attracted significant funding from various government agencies and industry to support his research.
Associate Professor Chang has also played a significant role in the strategic planning and development of the Centre for Complementary Medicine Research (CompleMED), one of the nine University Research Centres, and was Acting Director of CompleMED between March 2008 and May 2010. He has developed a number of significant research partnerships nationally and internationally with prestigious universities, research organisations and industry.
This information has been contributed by Doctor Chang.
Publications
Chapters in Books
- Chang, D., Nammi, S. and Grant, S. (2012), 'Traditional Understanding, Modern Science and Usage of Herbal Medicines for Diabetes', Innovation in Healthy and Functional Foods, Taylor & Francis 9781439862674.
- Doran , C., Chang, D., Kiat, H. and Bensoussan, A. (2012), 'Review of economic methods used in complementary medicine', Traditional, Complementary and Integrative Medicine : an International Reader, Palgrave 9780230232655.
- Chang, D., Nammi, S. and Grant, S. (2012), 'Traditional understanding, modern science, and usage of herbal medicines for diabetes', Innovation in Healthy and Functional Foods, CRC Press 9781439862674.
- Chang, D., Ghosh, D. and Bensoussan, A. (2010), 'Vitamins and complementary therapies used to treat Alzheimer's disease', Dementia, Hodder Education 9780340987278.
- Liang, H. and Chang, D. (2010), 'Cancer Clinical Trials on Chinese Medicine', Supportive Cancer Care with Chinese Medicine, Springer Publishing 978904813555.
- Chan, D., Ong, B. and Chang, D. (2006), 'Polypharmacy and Adverse Drug Reaction', Chan's Practical Geriatrics, BA Printing & Publishing Services 0646465961.
Journal Articles
- Grant, S., Chang, D., Fahey, P. and Bensoussan, A. (2013), 'Interrater reliability of Chinese medicine diagnosis in people with prediabetes', Evidence-Based Complementary and Alternative Medicine, 8.
- Siegler, J., Chang, D. and Cheema, B. (2013), 'Effect of aerobic training on cognitive function and arterial stiffness in sedentary young adults : a pilot randomized controlled trial', Physiology Journal, 9.
- Chang, D. (2013), 'Isolation and purification of four bioactive constituents from Alpinia officinarum Hance utilizing high-speed counter-current chromatography', Journal of Liquid Chromatography & Related Technologies, 11.
- Grant, S., Chang, D. and Bensoussan, A. (2013), 'Chinese herbal medicine for impaired glucose tolerance : a randomized placebo controlled trial', BMC Complementary and Alternative Medicine, 10.
- Melville, G., Chang, D., Colagiuri, B., Marshall, P. and Cheema, B. (2012), 'Fifteen minutes of chair-based yoga postures or guided meditation performed in the office can elicit a relaxation response', Evidence-based Complementary and Alternative Medicine, .
- Melville, G., Chang, D., Chang, D., Colagiuri, B., Marshall, P., Marshall, P. and Cheema, B. (2012), 'Fifteen minutes of chair-based yoga postures or guided meditation performed in the office can elicit a relaxation response', Evidence-based Complementary and Alternative Medicine, .
- Stough, C., Croft, K., Chang, D., Scholey, A., Pase, M., Cropley, V., Myers, S., Nolidin, K., King, R., Camfield, D., Wesnes, K. and Pipingas, A. (2012), 'A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning in cognitively healthy elderly people : the Australian Research Council Longevity Intervention (ARCLI) study protocol (ANZCTR12611000487910)', Nutrition Journal, 9.
- Grant, S., Bin, Y., Kiat, H. and Chang, D. (2012), 'The use of complementary and alternative medicine by people with cardiovascular disease : a systematic review', BMC Public Health, 9.
- Marshall, P., Chang, D., Colagiuri, B. and Machliss, B. (2011), 'Effect of an office worksite-based yoga program on heart rate variability: A randomized controlled trial', BMC Public Health, .
- Cheema, B., Marshall, P., Chang, D., Colagiuri, B. and Machliss, B. (2011), 'Effect of an office worksite-based yoga program on heart rate variability: A randomized controlled trial', BMC Public Health, 5.
- Kiat, H., Kiat, H., Bin, Y., Grant, S. and Chang, D. (2011), 'Complementary Medicine Use in Cardiovascular Disease: A Clinician's Viewpoint.', The Medical Journal of Australia, 3.
- Gray, M., Chang, D., Zhang, Y., Liu, J. and Bensoussan, A. (2010), 'Development of liquid chromatography/mass spectrometry methods for the quantitative analysis of herbal medicine in biological fluids: a review', Biomedical Chromatography, 13.
- Doran, C., Chang, D., Kiat, H., Kiat, H. and Bensoussan, A. (2010), 'Review of methodological approaches to economic analysis of complementary medicine interventions', Journal of Alternative and Complementary Medicine, 5.
- Grant, S., Bensoussan, A., Chang, D., Kiat, H., Kiat, H., Klupp, N., Liu, J. and Li, X. (2009), 'Chinese herbal medicines for people with impaired glucose tolerance or impaired fasting blood glucose', Cochrane Database of Systematic Reviews, 106.
- Grant, S., Bensoussan, A., Chang, D., Kiat, H., Klupp, N., Liu, J. and Li, X. (2009), 'Chinese herbal medicines for people with impaired glucose tolerance or impaired fasting blood glucose.', Cochrane database of systematic reviews (Online), .
- Klupp, N., Chang, D., Hawke, F., Kiat, H., Grant, S. and Bensoussan, A. (2008), 'Ganoderma lucidum for the treatment of cardiovascular risk factors', Cochrane Database of Systematic Reviews, .
- Grant, S., Bensoussan, A., Chang, D., Kiat, H., Klupp, N. and Liu, J. (2007), 'Chinese herbal medicines for people with impaired glucose tolerance or impaired fasting blood glucose dysmenorrhoea (protocol)', Cochrane Database of Systematic Reviews, 17.
- Liu, J. and Chang, D. (2006), 'Vascular Dementia', The Journal of Complementary Medicine, 7.
- Mather, L., Duke, C., Ladd, L., Copeland, S., Gallagher, G. and Chang, D. (2004), 'Direct cardiac effects of coronary site-directed thiopental and its enantiomers', Anesthesiology, 11.
- Mather, L., Ladd, L., Copeland, S. and Chang, D. (2004), 'Effects of imposed acid-base derangement on the cardiovasscular effects and pharmacokinetics of bupivacaine adn thiopental.', Anesthesioloy, 12.
- Ladd, L., Chang, D., Wilson, K., Copeland, S., Plummer, J. and Mather, L. (2002), 'Effects of CNS site-directed carotid arterial infusions of bupivacaine, levobupivacaine, and ropivacaine in sheep', Anesthesiology, 11.
- Chang, D., Ladd, L., Copeland, S., Iglesias, M., Plummer, J. and Mather, L. (2001), 'Direct cardiac effects of intracoronary bupivacaine, levobupivacaine and ropivacaine in the sheep', British Journal Of Pharmacology, 10.
- Mather, L. and Chang, D. (2001), 'Cardiotoxicity with modern local anaesthetics: Is there a safer choice', Drugs, 10.
Research
Current Projects
| Title: | A Multicentre, Randomised, Double-Blind, Placebo Controlled Trial to Evaluate the Effectiveness and Safety of Sailuotong (SLT), a Standardised Chinese Herbal Medicine Formula in Patients with Vascular Dementia and Alzheimer's Disease |
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| Years: | 2012-11-12 - 2016-03-31 |
| ID: | P00021324 |
| UWS Researchers: | Dennis Chang and Alan Bensoussan |
| Funding: |
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| Title: | Joint Chair in Traditional Chinese Medicine |
| Years: | 2008-06-01 - 2014-12-01 |
| ID: | P00016230 |
| UWS Researchers: | Alan Bensoussan and Dennis Chang |
| Funding: |
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| Title: | Naoxinqing Pian Research Program Phase I |
| Years: | 2011-10-21 - 2013-12-30 |
| ID: | P00020675 |
| UWS Researchers: | Dennis Chang, Kelvin Chan and Alan Bensoussan |
| Funding: |
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Previous Projects
| Title: | Developing a long term cardiovascular research plan in complementary medicine CM. Phase 1: review of clinical effectiveness & approaches to economic analysis of CM interventions |
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| Years: | 2006-07-11 - 2007-07-31 |
| ID: | P0015172 |
| UWS Researchers: | Dennis Chang and Alan Bensoussan |
| Funding: |
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| Title: | Development of analytical methodologies for quality assurance and bioavailability of Chinese herbal medicines |
| Years: | 2003-02-15 - 2004-02-24 |
| ID: | P0013690 |
| UWS Researchers: | Dennis Chang |
| Funding: |
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| Title: | Establishment of a Patient Information Database to monitor and evaluate clinical practice in Traditional Chinese Medicine (TCM) |
| Years: | 2002-05-01 - 2003-08-30 |
| ID: | P0010172 |
| UWS Researchers: | Dennis Chang |
| Funding: |
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| Title: | Clinical trial to evaluate the effectiveness of Ganoderma lucidum for treatment of Metabolic Syndrome |
| Years: | 2005-06-21 - 2010-12-31 |
| ID: | P0014830 |
| UWS Researchers: | Dennis Chang, Nerida Klupp and Alan Bensoussan |
| Funding: |
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| Title: | Collaboration on the development of validation methods for Chinese herbal medicines |
| Years: | 2003-06-23 - 2004-05-31 |
| ID: | P0013174 |
| UWS Researchers: | Alan Bensoussan, Dennis Chang and Cheang Khoo |
| Funding: |
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| Title: | Clinical Trial of a Chinese herbal medicine for Blood Pressure and Glycemic control - preliminary work |
| Years: | 2004-07-08 - 2004-12-31 |
| ID: | P0014394 |
| UWS Researchers: | Nerida Klupp and Dennis Chang |
| Funding: |
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| Title: | Creating scientifically validated and evidence based natural medicines: development of laboratories and clinical research capacity. |
| Years: | 2005-10-05 - 2006-10-04 |
| ID: | P0014811 |
| UWS Researchers: | Alan Bensoussan, Dennis Chang and Cheang Khoo |
| Funding: |
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| Title: | Developing bioavailability methods in herbal medicine |
| Years: | 2007-03-13 - 2007-08-31 |
| ID: | P0015147 |
| UWS Researchers: | Alan Bensoussan and Dennis Chang |
| Funding: |
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| Title: | Creating scientifically validated and evidence-based natural medicines. Phase 2: Development of the herbal pharmacology laboratory |
| Years: | 2006-09-01 - 2007-08-31 |
| ID: | P0015239 |
| UWS Researchers: | Alan Bensoussan, Dennis Chang and Cheang Khoo |
| Funding: |
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| Title: | Establishment of a mass spectrometer facility for natural products and proteomics research and teaching at the College of Health and Science within the University of Western Sydney, Campbelltown campus |
| Years: | 2008-09-24 - 2010-09-15 |
| ID: | P00016326 |
| UWS Researchers: | Nikolaus Sucher, Jens Coorssen, Jens Coorssen, Bill Price, Gerald Muench, Andrew Shalliker, Vincent Higgins, Dennis Chang, Sabine Piller, Simon Myers, Colin Stack and Michelle Moffitt |
| Funding: |
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| Title: | Laboratory characterization of Endoherb |
| Years: | 2008-11-19 - 2009-12-31 |
| ID: | P00016585 |
| UWS Researchers: | Cheang Khoo, Nikolaus Sucher, Dennis Chang and Alan Bensoussan |
| Funding: |
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| Title: | Traditional Chinese Medicine Diagnosis for Pre-Diabetes & Development of a Chinese Medicine Assessment Measure |
| Years: | 2008-07-02 - 2009-02-28 |
| ID: | P00016505 |
| UWS Researchers: | Dennis Chang and Suzanne Grant |
| Funding: |
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| Title: | Quality assurance and bioavailability of a Chinese herbal proprietary formula |
| Years: | 2002-12-16 - 2004-03-31 |
| ID: | P0010628 |
| UWS Researchers: | Alan Bensoussan, Cheang Khoo, Janice Aldrich-Wright, Andrew Shalliker, Kamali Kannangara, Dennis Chang and Mick Wilson |
| Funding: |
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| Title: | NICM TCM Neuroprotective effects of Chinese Herbal Medicine |
| Years: | 2008-08-21 - 2012-06-30 |
| ID: | P00016474 |
| UWS Researchers: | Dennis Chang |
| Funding: |
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| Title: | Curcuma Development Project: Stage I |
| Years: | 2009-02-19 - 2010-12-31 |
| ID: | P00017010 |
| UWS Researchers: | Dennis Chang and Nikolaus Sucher |
| Funding: |
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| Title: | Evaluation and validation of analytical methods for assessment of key markers or toxic constituents in commonly used Chinese herbs/herbal formulations |
| Years: | 2003-01-01 - 2003-12-31 |
| ID: | P0013868 |
| UWS Researchers: | Dennis Chang and Alan Bensoussan |
| Funding: |
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| Title: | A randomized, controlled clinical trial of the effectiveness of Chinese herbal medicine (CHM) in the treatment of vascular dementia |
| Years: | 2004-02-16 - 2007-05-31 |
| ID: | P0011626 |
| UWS Researchers: | Dennis Chang and Alan Bensoussan |
| Funding: |
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| Title: | A Randomized Placebo-Controlled Clinical Trial to Study the Therapeutic Effectiveness of a Chinese Herbal Medicine Formula Used for the Treatment of Vascular Dementia - No funding to UWS |
| Years: | 2007-05-08 - 2007-12-31 |
| ID: | P0015675 |
| UWS Researchers: | Dennis Chang and Alan Bensoussan |
| Funding: |
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| Title: | Evaluation of Clinical Efficacy of Chinese Herbal Medicine for the Management of Vascular Dementia |
| Years: | 2010-01-08 - 2011-01-07 |
| ID: | P00018031 |
| UWS Researchers: | Dennis Chang |
| Funding: |
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| Title: | Traditional Medicine Internationalisation Platform |
| Years: | 2011-06-30 - 2012-12-31 |
| ID: | P00020056 |
| UWS Researchers: | Alan Bensoussan, Kelvin Chan and Dennis Chang |
| Funding: |
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Supervision
Doctor Chang is available to be a principal supervisor for doctoral projects
Current Supervision
| Title: | Comparing Cardiovascular Outcomes of Two Modes of In-Centre Exercise Programs in End-Stage Renal Disease Patients Receiving Maintenance Haemodialysis |
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| Field of Research: |
