Doctor Janice Aldrich-Wright

Doctor Janice Aldrich-Wright

Adjunct Professor,
School of Medicine

PROFESSOR,
Dean's Unit - School of Science and Health

Biography

Janice Aldrich-Wright obtained her BAppSc (Hons) from University of Technology, Sydney and PhD from Macquarie University, Sydney. Subsequently she was awarded the Cornforth Medal, for the best PhD in Chemistry in Australia (1993). From 1993- till present she has been an associate lecturer, Lecture, Senior Lecture, Associate Professors and now a Professor in Chemistry at the University of Western Sydney. She is a fellow of the Royal Australian Chemical Institute and a Fellow of the Royal Society of Chemistry. She began with teaching in chemistry but quickly established a strong foundation in research and in this capacity, student mentorship. Her work is internationally recognised in the field of anticancer chemistry and pharmacology and she has published widely. Innovative bioinorganic molecular design, elegant synthesis, comprehensive characterisation (including X-ray analysis at the synchrotron) and the biophysical analysis of the interactions of these compounds with DNA using, for example synchrotron radiation circular Dichroism (SRCD – Aarhus, Denmark), exemplify her research while creating a vibrant, productive and collaborative environment for her research students.

This information has been contributed by Doctor Aldrich-Wright.

Qualifications

  • PhD Macquarie University
  • BAppSc NSW Institute of Technology

Professional Memberships

  • RACI (1993 - 2015)
  • RSC (2000 - 2015)

Organisational Unit (School / Division)

  • School of Medicine
  • Dean's Unit - School of Science and Health

Contact

Email: J.Aldrich-Wright@westernsydney.edu.au
Phone: (02) 4620 3218
Mobile:
Location: 21.G.43
Campbelltown
Website:

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Teaching

Previous Teaching Areas

  • 300324 Pharmacological Chemistry, 2015
  • 300412 Science, Technology and Environment Honours Project, 2015
  • 300800 Essential Chemistry 1, 2015
  • 800167 Research Literacies, 2015

Publications

Chapters in Books

  • Harper, B., Li, F., Beard, R., Garbutcheon-Singh, K., Ng, N. and Aldrich-Wright, J. (2013), 'Biomolecular ineractions of platinum complexes', Supramolecular Systems in Biomedical Fields, Royal Society of Chemistry 9781849736589.
  • Van Holst, M., Grant, M. and Aldrich-Wright, J. (2011), 'Target Biological Structures: The Cell, Organelles, DNA and RNA', Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules, Springer 9783211094273.
  • Orkey, N., Wormell, P. and Aldrich-Wright, J. (2011), 'Ruthenium Polypyridyl Metallointercalators', Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules, Springer 9783211094273.
  • Krause-Heuer, A., Manohar, M., Garbutcheon-Singh, K., Fisher, D. and Aldrich-Wright, J. (2011), 'The Synthesis of Platinum(II) Intercalators', Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules, Springer 9783211094273.
  • Harper, B., Van Holst, M. and Aldrich-Wright, J. (2011), 'Platinum(II) Intercalating Complexes Based on 2,2':6',2"-Terpyridine', Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules, Springer 9783211094273.
  • Salih, A., Wormell, P., Garbutcheon-Singh, K., Harper, B., Myers, S., Geny, D., Hammang, C. and Aldrich-Wright, J. (2011), 'Applications of Fluorescence Spectroscopy and Confocal Microscopy.', Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules, Springer 9783211094273.

Journal Articles

  • Fanna, D., Zhang, Y., Li, L., Karatchevtseva, I., Shepherd, N., Azim, A., Price, J., Aldrich-Wright, J., Reynolds, J. and Li, F. (2016), '3d transition metal complexes with a julolidine-quinoline based ligand : structures, spectroscopy and optical properties', Inorganic Chemistry Frontiers, vol 3, no 2 , pp 286 - 295.
  • Ang, D., Harper, B., Cubo, L., Mendoza, O., Vilar, R. and Aldrich-Wright, J. (2016), 'Quadruplex DNA-stabilising dinuclear platinum(II) terpyridine complexes with flexible linkers', Chemistry: A European Journal, vol 22, no 7 , pp 2317 - 2325.
  • Garbutcheon-Singh, K., Galanski, M., Keppler, B. and Aldrich-Wright, J. (2016), 'Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline)(1R,2R,4R/1S,2S,4S)-4-methyl-1,2-cyclohexanediamine)platinum(II)]2+ (PHEN-4-MeDACH)', Inorganica Chimica Acta, vol 441 , pp 152 - 156.
  • Taha, .., Siddiqui, K., Campanaro, S., Najnin, T., Deshpande, N., Williams, T., Aldrich-Wright, J., Wilkins, M., Curmi, P. and Cavicchioli, R. (2016), '[In Press] Single TRAM domain RNA-binding proteins in Archaea : functional insight from Ctr3 from the Antarctic methanogen Methanococcoides burtonii', Environmental Microbiology, .
  • Pages, B., Sakoff, J., Gilbert, J., Zhang, Y., Li, F., Preston, D., Crowley, J. and Aldrich-Wright, J. (2016), '[In Press] Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole 'click' ligands', Journal of Inorganic Biochemistry, .
  • Harper, B., Morris, T., Gailer, J. and Aldrich-Wright, J. (2016), '[In Press] Probing the interaction of bisintercalating (2,2':6',2''-terpyridine)platinum(II) complexes with glutathione and rabbit plasma', Journal of Inorganic Biochemistry, .
  • Ertanab, H., Cassela, C., Verma, A., Poljakc, A., Charlton, T., Aldrich-Wright, J., Omara, S., Siddiqui, K. and Cavicchioli, R. (2015), 'A new broad specificity alkaline metalloprotease from a Pseudomonas sp. isolated from refrigerated milk : role of calcium in improving enzyme productivity', Journal of Molecular Catalysis B: Enzymatic, vol 113 , pp 1 - 8.
  • Pages, B., Ang, D., Wright, E. and Aldrich-Wright, J. (2015), 'Metal complex interactions with DNA', Dalton Transactions, vol 44, no 8 , pp 3505 - 3526.
  • Harper, B. and Aldrich-Wright, J. (2015), 'The synthesis, characterisation and cytotoxicity of bisintercalating (2,2':6',2''-terpyridine)platinum(II) complexes', Dalton Transactions, vol 44, no 1 , pp 87 - 96.
  • Ang, D., Jones, N., Stootman, F., Ghadirian, B. and Aldrich-Wright, J. (2015), 'Improved DNA equilibrium binding affinity determinations of platinum(II) complexes using synchrotron radiation circular dichroism', Analyst, vol 140, no 12 , pp 4162 - 4169.
  • Li, L., Saigo, N., Zhang, Y., Fanna, D., Shepherd, N., Clegg, J., Zheng, R., Hayami, S., Lindoy, L., Aldrich-Wright, J., Li, C., Reynolds, J., Harman, D. and Li, F. (2015), 'A large spin-crossover [Fe4L4]8+ tetrahedral cage', Journals of Materials Chemistry C, vol 3, no 30 , pp 7878 - 7882.
  • Pages, B., Zhang, Y., Li, F., Sakoff, J., Gilbert, J. and Aldrich-Wright, J. (2015), 'Cytotoxicity and structural analyses of 2,2'-Bipyridine-,4,4'-Dimethyl-2,2'-bipyridine- and 2-(2'-Pyridyl)-quinoxalineplatinum(II) complexes', European Journal of Inorganic Chemistry, vol 2015, no 25 , pp 4167 - 4175.
  • Macias, F., Deo, K., Pages, B., Wormell, P., Clegg, J., Zhang, Y., Li, F., Zheng, G., Aldrich-Wright, J. and [and two others], .. (2015), 'Synthesis and analysis of the structure, diffusion and cytotoxicity of heterocyclic platinum(IV) complexes', Chemistry: A European Journal, vol 21, no 47 , pp 16990 - 17001.
  • Reichel, F., Clegg, J., Gloe, K., Gloe, K., Weigand, J., Reynolds, J., Li, C., Aldrich-Wright, J., Kepert, C., Lindoy, L., Yao, H. and Li, F. (2014), 'Self-assembly of an imidazolate-bridged FeIII/CuII heterometallic cage', Inorganic Chemistry, vol 53, no 2 , pp 688 - 690.
  • Garbutcheon-Singh, K., Harper, B., Myers, S. and Aldrich-Wright, J. (2014), 'Combination studies of platinum(II)-based metallointercalators with buthionine-S,R-sulfoximine, 3-bromopyruvate, cisplatin or carboplatin', Metallomics, vol 6, no 1 , pp 126 - 131.
  • Beeton, M., Aldrich-Wright, J. and Bolhuis, A. (2014), 'The antimicrobial and antibiofilm activities of copper(II) complexes', Journal of Inorganic Biochemistry, vol 140 , pp 167 - 172.
  • Callari, M., Aldrich-Wright, J., de Souza, P. and Stenzel, M. (2014), 'Polymers with platinum drugs and other macromolecular metal complexes for cancer treatment', Progress in Polymer Science, vol 39, no 9 , pp 1614 - 1643.
  • Millington, C., Sonego, S., Karunaweera, N., Rangel, A., Aldrich-Wright, J., Campbell, I., Gyengesi, E. and Muench, G. (2014), 'Chronic neuroinflammation in Alzheimer's disease : new perspectives on animal models and promising candidate drugs', BioMed Research International, vol 2014 .
  • Bolhuis, A. and Aldrich-Wright, J. (2014), 'DNA as a target for antimicrobials', Bioorganic Chemistry, vol 55 , pp 51 - 59.
  • Pages, B., Li, F., Wormell, P., Ang, D., Clegg, J., Kepert, C., Spare, L., Danchaiwijit, S. and Aldrich-Wright, J. (2014), 'Synthesis and analysis of the anticancer activity of platinum(II) complexes incorporating dipyridoquinoxaline variants', Dalton Transactions, vol 43, no 41 , pp 15566 - 15575.
  • Wright, E., Padula, M., Higgins, V., Aldrich-Wright, J. and Coorssen, J. (2014), 'A systems biology approach to understanding the mechanisms of action of an alternative anticancer compound in comparison to cisplatin', Proteomes, vol 2, no 4 , pp 501 - 526.
  • Ng, N., Leverett, P., Hibbs, D., Yang, Q., Bulanadi, J., Wu, M. and Aldrich-Wright, J. (2013), 'The antimicrobial properties of some copper(II) and platinum(II) 1,10-phenanthroline complexes', Dalton Transactions, vol 42, no 9 , pp 3196 - 3209.
  • Garbutcheon-Singh, K., Leverett, P., Myers, S. and Aldrich-Wright, J. (2013), 'Cytotoxic platinum(II) intercalators that incorporate 1R,2R-diaminocyclopentane', Dalton Transactions, vol 42, no 4 , pp 918 - 926.
  • Petitjean, H., Guiglion, P., In, M., Aldrich-Wright, J., Castignolles, P., Ganachaud, F. and Gaborieau, M. (2013), 'Supramolecular organization of protonated aminosilicones in water', Journal of Colloid and Interface Science, vol 408 , pp 87 - 93.
  • Garbutcheon-Singh, K., Myers, S., Harper, B., Ng, N., Dong, Q., Xie, C. and Aldrich-Wright, J. (2013), 'The effects of 56MESS on mitochondrial and cytoskeletal proteins and the cell cycle in MDCK cells', Metallomics, vol 5, no 8 , pp 1061 - 1067.
  • Maniego, A., Ang, D., Guillaneuf, Y., Lefay, C., Gigmes, D., Aldrich-Wright, J., Gaborieau, M. and Castignolles, P. (2013), 'Separation of poly(acrylic acid) salts according to topology using capillary electrophoresis in the critical conditions', Analytical and Bioanalytical Chemistry, vol 405, no 28 , pp 9009 - 9020.
  • Orkey, N., Taleb, R. and Aldrich-Wright, J. (2012), 'Synthesis and characterisation of metallopolyamide complexes', Inorganica Chimica Acta, vol 393 , pp 187 - 197.
  • Krause-Heuer, A., Price, W. and Aldrich-Wright, J. (2012), 'Spectroscopic investigations on the interactions of potent platinum(II) anticancer agents with bovine serum albumin', Journal of Chemical Biology, vol 5, no 3 , pp 105 - 113.
  • Davis, K., Carrall, J., Lai, B., Aldrich-Wright, J., Ralph, S. and Dillon, C. (2012), 'Does cytotoxicity of metallointercalators correlate with cellular uptake or DNA affinity?', Dalton Transactions, vol 41, no 31 , pp 9417 - 9426.
  • Krause-Heuer, A., Leverett, P., Bolhuis, A. and Aldrich-Wright, J. (2012), 'Copper(ii) and palladium(ii) complexes with cytotoxic and antibacterial activity', Australian Journal of Chemistry, vol 65, no 7 , pp 860 - 873.
  • Wang, S., Wu, M., Higgins, V. and Aldrich-Wright, J. (2012), 'Comparative analyses of cytotoxicity and molecular mechanisms between platinum metallointercalators and cisplatin', Metallomics, vol 4, no 9 , pp 950 - 959.
  • Wang, S., Higgins, V., Aldrich-Wright, J. and Wu, M. (2012), 'Identification of the molecular mechanisms underlying the cytotoxic action of a potent platinum metallointercalator', Journal of Chemical Biology, vol 5, no 2 , pp 51 - 61.
  • Aldrich-Wright, J. (2012), 'Metallo-helical complexes resolutely pure helices', Nature Chemistry, vol 4, no 1 , pp 10 - 11.
  • Garbutcheon-Singh, K., Grant, M., Harper, B., Manohar, M., Krause-Heuer, A., Orkey, N. and Aldrich-Wright, J. (2011), 'Transition metal based anticancer drugs', Current Topics in Medicinal Chemistry, vol 11, no 5 , pp 521 - 542.
  • Bolhuis, A., Hand, L., Marshall, J., Richards, A., Rodger, A. and Aldrich-Wright, J. (2011), 'Antimicrobial activity of ruthenium-based intercalators', European Journal of Pharmaceutical Sciences, vol 42, no 4 , pp 313 - 317.
  • Moretto, J., Chauffert, B., Ghiringhelli, F., Aldrich-Wright, J. and Bouyer, F. (2011), 'Discrepancy between in vitro and in vivo antitumor effect of a new platinum(II) metallointercalator', Investigational New Drugs, vol 29, no 6 , pp 1164 - 1176.
  • Harper, B., Krause-Heuer, A., Grant, M., Manohar, M., Garbutcheon-Singh, K. and Aldrich-Wright, J. (2010), 'Advances in platinum chemotherapeutics', Chemistry: A European Journal, vol 16, no 24 , pp 7064 - 7077.
  • Talib, J., Harman, D., Dillon, C., Aldrich-Wright, J., Beck, J. and Ralph, S. (2009), 'Does the metal influence non-covalent binding of complexes to DNA', Dalton Transactions, vol 38, no 3 , pp 504 - 513.
  • Grant, M., Wheate, N. and Aldrich-Wright, J. (2009), 'Diffusion coefficient of curcurbit[n]urils (n=6 or 7) at various concentrations, temperature and pH', Journal of Chemical & Engineering Data, vol 54, no 2 , pp 323 - 326.
  • Pisani, M., Wheate, N., Keene, F., Aldrich-Wright, J. and Collins, J. (2009), 'Anionic PAMAM dendrimers as drug delivery vehicles for transition metal-based anticancer drugs', Journal of Inorganic Biochemistry, vol 103, no 3 , pp 373 - 380.
  • Jones, D., Van Host, M., Yano, S., Tanase, T. and Aldrich-Wright, J. (2009), 'N-Glycoside Complexes of Nickel(II); Probing Carbohydrate-Transition Metal Interactions', Australian Journal of Chemistry, vol 62, no 3 , pp 265 - 268.
  • Krause-Heuer, A., Wheate, N., Price, W. and Aldrich-Wright, J. (2009), 'Diffusion-based studies on the self-stacking and nanorod formation of platinum(II) intercalators', Chemical Communications, vol 10 , pp 1210 - 1212.
  • Krause-Heuer, A., Grnert, R., Khne, S., Buczkowska, M., Wheate, N., Le Pevelen, D., Boag, L., Fisher, D., Kasparkova, J., Malina, J., Bednarski, P., Brabec, V. and Aldrich-Wright, J. (2009), 'Studies of the Mechanism of Action of Platinum (II) complexes with Potent Cytotoxicity in Human Cander Cells', Journal of Medicinal Chemistry, vol 52, no 17 , pp 5474 - 5484.
  • Talib, J., Beck, J., Urathamakul, T., Nguyen, C., Aldrich-Wright, J., Mackay, J. and Ralph, S. (2009), 'A mass spectrometric investigation of the ability of metal complexes to modulate transcription factor activity', Chemical Communications, , no 37 , pp 5546 - 5548.
  • Amon, M., Ali, M., Bender, V., Hall, K., Aguilar, M., Aldrich-Wright, J. and Manolios, N. (2008), 'Kinetic and conformational properties of a novel T-cell antigen receptor transmembrane peptide in model membranes', Journal of Peptide Science, vol 14, no 6 , pp 714 - 724.
  • Urathamakul, T., Waller, D., Beck, J., Aldrich-Wright, J. and Ralph, S. (2008), 'Comparison of Mass Spectrometry and Other Techniques for Probing Interactions Between Metal Complexes and DNA', Inorganic Chemistry, vol 47, no 15 , pp 6621 - 6632.
  • Krause-Heuer, A., Wheate, N., Tilby, M., Pearson, G., Ottley, C. and Aldrich-Wright, J. (2008), 'Substituted B Cyclodextrin and Calix[4]arene as Encapsulatory Vehicles for Platinum(II)-Based DNA Intercalators', Inorganic Chemistry, vol 47, no 15 , pp 6880 - 6888.
  • Kemp, S., Wheate, N., Pisani, M. and Aldrich-Wright, J. (2008), 'Degredation of Bidentate-Coordinated Platinum(II) Based DNA Intercalators by Reduced L-Glutathione', Journal of Medicinal Chemistry, vol 51, no 9 , pp 2787 - 2794.
  • Wheate, N., Payyadi Govardhan, A., Torres, A., Aldrich-Wright, J. and Price, W. (2008), 'Examination of cucurbit[7]uril and its host-guest complexes by diffusion nuclear magnetic resonance', Journal of Physical Chemistry B, vol 112, no 8 , pp 2311 - 2314.
  • Talib, J., Green, C., Davis, K., Beck, J., Urathamakul, T., Aldrich-Wright, J. and Ralph, S. (2008), 'A comparison of the binding of metal complexes to duplex and quadruplex DNA', Journal of the Chemical Society, Dalton Transactions, vol 8 , pp 1018 - 1026.
  • Van Holst, M., Le Pevelen, D. and Aldrich-Wright, J. (2008), 'Terpyridineplatinum (II) Incorporation in N-Methylpyrrole-Based Polyamides by Solid Phase Techniques', European Journal of Inorganic Chemistry, vol 29 , pp 4608 - 4615.
  • Krause-Heuer, A., Grant, M., Orkey, N. and Aldrich-Wright, J. (2008), 'Drug Delivery Devices and Targeting Agents for Platinum (II) Anticancer Complexes', Australian Journal of Chemistry, vol 61, no 9 , pp 675 - 681.
  • Fisher, D., Fenton, R. and Aldrich-Wright, J. (2008), 'In vivo studies of platinum (II) metallointercalators', Chemical Communications, vol 43 , pp 5613 - 5615.
  • Yousouf, S., Brodie, C., Wheate, N. and Aldrich-Wright, J. (2007), 'Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by L-cysteine methyl ester', Polyhedron, vol 26, no 2 , pp 318 - 328.
  • Still, B., Payyadi Govardhan, A., Aldrich-Wright, J. and Price, W. (2007), '195Pt NMR-theory and application', Chemical Society Reviews, vol 36 , pp 665 - 686.
  • Taleb, R., Jaramillo, D., Wheate, N. and Aldrich-Wright, J. (2007), 'Synthesis of DNA-sequence-selective hairpin polyamide platinum complexes', Chemistry: A European Journal, vol 13, no 11 , pp 3177 - 3186.
  • Fisher, D., Bednarski, P., Grunert, R., Turner, P., Fenton, R. and Aldrich-Wright, J. (2007), 'Chiral platinum(II) metallointercalators with potent in vitro cytotoxic activity', ChemMedChem, vol 2, no 4 , pp 488 - 495.
  • Wheate, N., Brodie, C., Collins, G., Kemp, S. and Aldrich-Wright, J. (2007), 'DNA intercalators in cancer therapy: Organic and inorganic drugs and their spectroscopic tools of analysis', Mini Reviews in Medicinal Chemistry, vol 7, no 6 , pp 627 - 648.
  • Kemp, S., Wheate, N., Buck, D., Nikac, M., Collins, J. and Aldrich-Wright, J. (2007), 'The effect of ancillary ligand chirality and phenanthroline functional group substitution on the cytotoxicity of platinum(II)-based metallointercalators', Journal of Inorganic Biochemistry, vol 101, no 7 , pp 1049 - 1058.
  • Aldrich-Wright, J., Fenton, R., Leverett, P., Stephens, F., Williams, P. and Vagg, R. (2007), 'The synthesis and structural analysis of cis-beta-{(1,6-di(2'-pyridyl)(2,5-dibenzyl-2,5-diazahexane)(1,2-diazahexane)(1,2-benzoquinone diimine)ruthenium(II)} and related complexes', Journal of Coordination Chemistry, vol 60, no 17-19 , pp 2015 - 2034.
  • Kemp, S., Wheate, N., Stootman, F. and Aldrich-Wright, J. (2007), 'The host-guest chemistry of proflavine with cucurbit[6,7,8]urils', Supramolecular Chemistry, vol 19, no 7 , pp 475 - 484.
  • Wheate, N., Taleb, R., Krause-Heuer, A., Cook, R., Higgins, V., Aldrich-Wright, J. and Wang, S. (2007), 'Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles', Journal of the Chemical Society, Dalton Transactions, , pp 5055 - 5064.
  • Brodie, C. and Aldrich-Wright, J. (2007), 'Synthesis of Flexible Bis-Intercalating Ruthenium (II) Complexes', European Journal of Inorganic Chemistry, vol 30 , pp 4781 - 4793.
  • Kemp, S., Wheate, N., Wang, S., Collins, G., Higgins, V., Aldrich-Wright, J., Ralph, S. and Day, A. (2007), 'Encapsulation of platinum(II)-based DNA intercalators within cucurbit[6,7,8]urils', Journal of Biological Inorganic Chemistry, vol 12, no 7 , pp 969 - 979.
  • Jaramillo, D., Junk, P., Brodie, C. and Aldrich-Wright, J. (2006), 'chloro(dimehtylsulfoxide-kS)[(1R,3S)-1,2,2-trimethylcyclopentane-1,3-diamine-k2N,N']platinum(II) trichloro(dimethyl sulfoxide-kS)platinum(II)', Acta Crystallographica E, vol E62 , pp 3377 - 3379.
  • Stootman, F., Fisher, D., Rodger, A. and Aldrich-Wright, J. (2006), 'Improved curve fitting procedures to determine equilibrium binding constants', The Analyst, vol 131, no 10 , pp 1145 - 1151.
  • Brodie, C., Turner, P., Wheate, N. and Aldrich-Wright, J. (2006), '(4,7-dimethyl-1,10-phenanthroline)ethylenediamine)platinum(II) dichloride tris(deuterium oxide) solvate', Acta Crystallographica. Section E: Structure Reports Online, vol E62 , pp 3137 - 3139.
  • Jaramillo, D., Buck, D., Collins, J., Wheate, N., Stootman, F., Aldrich-Wright, J. and Fenton, R. (2006), 'Synthesis, characterisation and biological activity of chiral platinum(II) complexes', European Journal of Inorganic Chemistry, vol 4 , pp 839 - 849.
  • Jaramillo, D., Wheate, N., Ralph, S., Howard, W., Tor, Y. and Aldrich-Wright, J. (2006), 'Polyamide platinum anticancer complexes designed to target specific DNA sequences', Inorganic Chemistry, vol 45, no 15 , pp 6004 - 6013.
  • Jaramillo, D., Liu, Q., Aldrich-Wright, J. and Yitzhak, T. (2004), 'Synthesis of N-Methylpyrrole and N-Methylimidaqzole Amino Acids Suitable for Solid-Phase Synthesis', Journal of Organic Chemistry, vol 69 , pp 8151 - 8153.
  • Brodie, C., Collins, J. and Aldrich-Wright, J. (2004), 'DNA binding and biological activity of some platinum(II) intercalating compounds containing methyl-substituted 1,10-phenanthrolines', Dalton Transactions, , pp 1145 - 1152.
  • Urathamakul, T., Beck, J., Sheil, M., Aldrich-Wright, J. and Ralph, S. (2004), 'A mass spectrometric investigation of non-covalent interactions between ruthenium complexes and DNA', Dalton Transactions, , pp 2683 - 2690.
  • Gupta, R., Beck, J., Ralph, S., Sheil, M. and Aldrich-Wright, J. (2004), 'Comparison of the Binding Stoichiometries of Positively Charged DNA-Binding Drugs using positive and negative ion electrospray ionization mass spectrometry', American Society for Mass Spectronomy Journal, vol 15 , pp 1382 - 1391.
  • Aldrich-Wright, J., Brodie, C., Glazer, E., Luedtke, N., Elson-Schwab, L. and Tor, Y. (2004), 'Symmetrical dinuclear complexes with high DNA affinity based on [Ru(dpq)2(phen)]2+', Chemical Communications, , pp 1018 - 1019.
  • Pellegrini, P. and Aldrich-Wright, J. (2003), 'Evidence for chiral discrimination of ruthenium(II) polypyridyl complexes by DNA', Dalton Transactions, , pp 176 - 183.
  • Aldrich-Wright, J., Vagg, J. and Williams, P. (2003), 'HPLC separation of diasteromeric metal complexes of the form Delta, Lambda-[Ru(diimine)2(S-aminoacidate)].', Australian Journal of Chemistry, , pp 1193 - 1200.
  • Aldrich-Wright, J. and Howard, W. (2003), 'DNA binding studies of ruthenium (II) dipyridotetrahydrophenazine complexes', Journal of Inorganic Biochemistry, , pp 152 - 152.
  • Aldrich-Wright, J., Jaramillo, D., Collins, G. and Junk, P. (2003), 'The structure-Activity relationship of Chiral Square-Planar Platinum(II) Metallointercalators', Journal of Inorganic Biochemistry, , pp 159 - 159.
  • Aldrich-Wright, J., Ralph, S., Gupta, R., Urathamakul, T., Sheil, M. and Beck, J. (2003), 'Probing the DNA selectivity of Ruthenium Metallointercalators usin ESI Mass Spectometry', Journal of Inorganic Biochemistry, , pp 214 - 214.
  • Aldrich-Wright, J., Yousouf, S. and Brodie, C. (2003), 'Synthesis of Ruthenuym-Platinum Di- and Tri- nuclear Complexes', Journal of Inorganic Biochemistry, , pp 259 - 259.
  • Aldrich-Wright, J., Collins, G. and Keene, R. (2003), 'Dinuclear Ruthenium Complexes as Sequence- and Structure-Selective binding agents for DNA', Journal of Inorganic Biochemistry, , pp 90 - 90.
  • Aldrich-Wright, J., Brodie, C., Glazer, E., Luedtke, N. and Tor, Y. (2003), 'Synthesis and DNA binding of bisintercalating complexes of the type [(dpq)(2)Ru(phen-n-SOS-n-phen)Ru(dpq)(2)](4+)', Journal of Inorganic Biochemistry, , pp 105 - 105.
  • Aldrich-Wright, J., Fenton, R. and Fisher, D. (2003), 'Platinum(II) Intercalators as potential Anti-Cancer Agents', Journal of Inorganic Biochemistry, , pp 106 - 106.
  • Aldrich-Wright, J., Hinds, F., Leverett, P. and Hazell, S. (2003), 'Synthesis, characterisation and anti bacterial testing of Bismuth maltol', Journal of Inorganic Biochemistry, , pp 144 - 144.
  • Aldrich-Wright, J., Van Holst, M. and Jaramillo, D. (2003), 'The Synthesis of 2,3-Diamino-2,3-dideoxy-a-D-glucose, 3,4-Diamino-6-hydroxymethyl-tetrahydro-pyran-2,5-diol and their Chiral Platinum Compounds', Journal of Inorganic Biochemistry, , pp 151 - 151.
  • Back, J., Gupta, R., Urathamakul, T., Williamson, N., Sheil, M., Aldrich-Wright, J. and Ralph, S. (2003), 'Probing DNA selectivity of ruthenium metallointercalators using ESI mass spectrometry', Chemical Communications, vol 9, no 5 , pp 626 - 627.
  • Greguric, A., Greguric, I., Hambley, T., Aldrich-Wright, J. and Collins, G. (2002), 'Minor Groove Intercalation of D-[Ru(Me2phen)2dppz]2+ to the Hexanucleotide d(GTCGAC)2', Journal of the Chemical Society, Dalton Transactions, vol 6 , pp 849 - 855.
  • Hinds, F., Harris, A., Campbell, M., Aldrich-Wright, J. and Hazell, S. (2002), 'Iron transport systems are necessary to Helicobacter pylori, providing a level of protection against bismuth activity.', Gut, .
  • Aldrich-Wright, J., Fenton, R., Greguric, I., Hambley, T. and Williams, P. (2002), 'The stereospecific synthesis of Lambda-alpha-{dipyrido[3,2-a:2'3'-c](6,7,8,9-tetrahydro)phenazine[N,N'-di(2-picolyl)-2,5-dimethyl-2S,5S-diaminocyclohexane]ruthenium(II)} and related beta isomers', Journal of the Chemical Society, Dalton Transactions, , pp 4666 - 4671.

Conference Papers

  • Aldrich-Wright, J., Wheate, N. and Taleb, R. (2007), 'Novel platinum(II) based anticancer drugs; metallointercalators and DNA sequence specific agents', 13th International Conference on Biological Inorganic Chemistry, Vienna, Austria.
  • Aldrich-Wright, J., Wheate, N., Wright, E., Dawes, I. and Higgins, V. (2007), 'Molecular mechanisms involved in the Saccharomyces cerevisiae response to the novel anticance platinum compond 56MESS', 13th International Conference on Biological Inorganic Chemistry, Vienna, Austria.
  • Aldrich-Wright, J., Wheate, N. and Krause-Heuer, A. (2007), 'Use of molecular hosts in the drug delivery of platinum(II) based DNA intercalating agents', 13th International Conference on Biological Inorganic Chemistry, Vienna, Austria.
  • Wang, S., Cook, R., Aldrich-Wright, J. and Higgins, V. (2007), 'Structure-cytotoxicity relationships of novel platinum anticancer drugs in cancer cells and Saccharomyces cerevisiae', XXIIIrd International Conference of Yeast Genetics and Molecular Biology, Melbourne, Australia.
  • Wright, E., Aldrich-Wright, J., Wheate, N., Dawes, I. and Higgins, V. (2007), 'The use of a Saccharomyces cerevisiae deletion mutant library to elucidate the molecular mechanisms involved in the eukaryote response to the novel platinum anticancer compound 56MESS', XXIIIrd International Conference of Yeast Genetics and Molecular Biology, Melbourne, Australia.
  • Miyoshi, E., Price, W. and Aldrich-Wright, J. (2005), 'Multinuclear NMR and in vivo studies of platinum-based anti-cancer drugs.', College of Science, Technology and Environment Innovation Conference 2005, Werrington South, NSW, Australia.
  • Apps, M., Price, W. and Aldrich-Wright, J. (2005), 'NMR and optical studies of the association of biomolecules', College of Science, Technology and Environment Innovation Conference 2005, Werrington South, NSW, Australia.

Other Publications

  • 2002, '', Patent
  • 2002, '', Patent

Research

Understanding how molecules find a unique binding position on a segment of DNA ranks among the most fascinating and important current chemical and/or biochemical questions because it is absolutely essential for determining how biological systems work. The rational design of therapeutic drugs design requires an understanding of the physical and chemical principles involved in DNA and RNA recognition and for improved design this information is essential. My research objective has been to significantly extend our understanding of the principles involved in sequence-specific recognition of biological molecules like DNA by carrying out investigations of the binding of metal complexes. The result of this work has far-reaching consequences on the rational design of DNA-based chemotherapeutic agents, effective DNA probes and DNA-sequencing agents. To achieve these objectives a number of metal complexes have been designed, synthesised, resolved and characterised in order to aid our understand of how DNA discriminates between simple molecules by determining their binding affinity and biological activity.

Octahedral metallointercalators are a class of compounds which have been extensively used as probes for DNA recognition. There has been considerable interest, and controversy, in determining their precise mode of DNA binding. Our studies were able to unambiguously demonstrate that these metal complexes could intercalate from the minor groove.

Platinum compounds that are in clinical use, such as cisplatin and its analogues, exhibit their activity by binding covalently to DNA in the cancerous cell thus preventing cell division. The potent compounds we investigate interact in an entirely different way with DNA, through non-covalent interactions. They are highly soluble in water, show very high level of activity in cell lines suggesting they are likely to demonstrate high clinical activity and effectiveness at low dosage and exhibit a high level of activity against cisplatin resistant cell lines.

Microbial biofilm infections play a significant role in chronic infections within the healthcare system due mainly to their resistance to antibiotic treatments. We have determined that our copper complexes exhibit antibacterial activity against the biofilms of Staphylococcus aureus and yeast Candida krusei.

This information has been contributed by Doctor Aldrich-Wright.

Previous Projects

Title: Sequence selective platinum drugs for DNA
Years: 2004-02-16 - 2005-02-15
ID: P0011764
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: The Synthesis of Bis-intercalating Metal Complexes with Sequence-Specific Recognition in the Minor Groove of DNA
Years: 2001-01-01 - 2001-12-31
ID: P0011868
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: The Biological Evaluation of Bis-intercalating Metal Complexes
Years: 2002-01-01 - 2002-12-31
ID: P0011534
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: The Synthesis of Sequence-Selective Platinum Drugs
Years: 2003-01-04 - 2004-01-31
ID: P0011686
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Newbio Pre-establishment Project
Years: 2005-03-01 - 2006-03-01
ID: P0014710
Western Researchers: Janice Aldrich-Wright
Funding:
  • Newbio Limited
Title: Vibrational Spectroscopy /Microprobe/FESEM/AFM Imaging Cells, Tissues and Materials [via USYD]
Years: 2005-04-04 - 2006-04-04
ID: P0014725
Western Researchers: Janice Aldrich-Wright
Funding:
  • Australian Research Council (non ACRG)
Title: Anti Cancer - Intercalating Metal Complexes (Project 2)
Years: 2005-05-10 - 2007-06-30
ID: P0014745
Western Researchers: Janice Aldrich-Wright
Funding:
  • Newbio Limited
Title: Anti Cancer - Sequence Selective Compounds (Project 3)
Years: 2005-05-11 - 2007-06-30
ID: P0014746
Western Researchers: Janice Aldrich-Wright
Funding:
  • Newbio Limited
Title: Platinum (II) Anticancer Drugs
Years: 2005-12-21 - 2006-02-28
ID: P0014990
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Investigations into Metallodrugs Mechanisms of Action
Years: 2007-06-05 - 2008-06-04
ID: P0015647
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Developing comprehensive methods for bimolecular analysis using NMR, Circular Dichroism (CD) and Linear Dichroism (LD) to understand of the mechanisms of intermolecular interactions
Years: 2007-08-06 - 2012-09-30
ID: P0015753
Western Researchers: Janice Aldrich-Wright and Bill Price
Funding:
  • University of Western Sydney
Title: Are Linked Bisintercalating Platinum (II) Compounds Effective as Anticancer Agents?
Years: 2007-12-10 - 2008-12-09
ID: P0015919
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Using Circular and Linear Dichromism to Understand the Binding Interactions of Platinum (II) Intercalculators with Biomolecules
Years: 2006-06-08 - 2007-06-07
ID: P0015163
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Programmable Peltier Temperature Controller
Years: 2006-11-15 - 2006-12-31
ID: P0015270
Western Researchers: Janice Aldrich-Wright, Bill Price, Vincent Higgins and Frank Stootman
Funding:
  • Ramaciotti Australia Foundation
Title: Anionic dendrimers for improved delivery of platinum anticancer drugs
Years: 2006-12-20 - 2008-01-03
ID: P0015411
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Ultra-high resolution magnetic resonance imaging (MRI) system for physical applications
Years: 2014-05-06 - 2015-05-05
ID: P00021626
Western Researchers: Bill Price, Janice Aldrich-Wright, Annemarie Hennessy, Sathaa Sathasivan and Allan Torres
Funding:
  • University of New England
  • Australian Research Council (non ACRG)
  • South Western Sydney Local Health District
  • Surgical Diagnostics Pty Ltd
  • University of Sydney
  • University of Western Australia
  • University of South Australia
  • Ingham Institute for Applied Medical Research
  • University of New South Wales
Title: Synthesising G4-DNA Metallodrugs
Years: 2013-12-09 - 2014-12-09
ID: P00021829
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Identifying new cytotoxic agents
Years: 2014-05-13 - 2015-06-30
ID: P00022248
Western Researchers: Janice Aldrich-Wright
Funding:
  • Anonymous Donation
Title: Developing Platinum(IV) prodrugs [no funding to UWS]
Years: 2014-10-26 - 2015-06-26
ID: P00021884
Western Researchers: Janice Aldrich-Wright
Funding:
  • The Lady Davis Fellowship Trust
Title: COST Action CM1105 Management Committee Meeting and Whole Action Meeting
Years: 2012-09-12 - 2012-09-25
ID: P00021139
Western Researchers: Janice Aldrich-Wright
Funding:
  • Department of Industry, Innovation and Science (nonACRG)
Title: Spin - Switch Materials in Molecular Recognition: towards Molecular devices
Years: 2012-11-13 - 2013-11-12
ID: P00021171
Western Researchers: Feng Li and Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Designing multidentate ligands for lanthanide complexes for the visualization of cellular components
Years: 2012-03-02 - 2013-07-31
ID: P00020540
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: SRCD study of copper metallointercalators and their effect on biomacromolecule
Years: 2013-09-16 - 2013-09-23
ID: P00021670
Western Researchers: Janice Aldrich-Wright
Funding:
  • Australian Synchrotron Company Ltd
Title: Quality assurance and bioavailability of a Chinese herbal proprietary formula
Years: 2002-12-16 - 2004-03-31
ID: P0010628
Western Researchers: Alan Bensoussan, Cheang Khoo, Janice Aldrich-Wright, Andrew Shalliker, Kamali Kannangara, Dennis Chang and Mick Wilson
Funding:
  • AusIndustry - Dept Industry Science & Resources
Title: Isolation and Characterisation of individual components of complex organic mixtures using Liquid Chromatography-Mass Spectrometry (LC-MS/MS)
Years: 2005-10-05 - 2006-10-04
ID: P0014808
Western Researchers: Kamali Kannangara, Andrew Shalliker and Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Dinuclear Ruthenium Complexes as Sequence- and Structure-Selective Binding Agents for DNA - DP0343480 [via James Cook University]
Years: 2003-01-01 - 2005-12-31
ID: P0009800
Western Researchers: Janice Aldrich-Wright
Funding:
  • Australian Research Council (ACRG)
Title: Circular Dichroism - Measuring molecular interactions and dynamics in biological chemistry [via Macquarie Uni]- RIEF: R00107905
Years: 2001-01-01 - 2001-12-31
ID: P0013590
Western Researchers: Janice Aldrich-Wright, Stuart Hazell and Jo-Anne Chuck
Funding:
  • Australian Research Council (ACRG)
Title: Electrochemical Electron Spin Resonance Spectrometer [via University of Wollongong]
Years: 2004-01-01 - 2004-12-31
ID: P0013600
Western Researchers: Janice Aldrich-Wright
Funding:
  • Australian Research Council (non ACRG)
Title: The Selective DNA Binding of Chrial Metal Complexes
Years: 1998-01-01 - 1998-12-31
ID: P0011170
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: The Synthesis and Characterisation of Carbohydrate-Metal Complexes for Interaction with DNA
Years: 1999-01-01 - 1999-12-31
ID: P0011176
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Synthsesis and Resolution of Chiral Metal Complexes for Selective DNA Binding
Years: 1999-01-01 - 1999-12-31
ID: P0011180
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Chiral Metal Complexes
Years: 2000-01-01 - 2001-12-31
ID: P0011192
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Design and Synthesis of Dinuclear Metal Complexes with Sequences-Specific Recognition in the DNA Minor Grove
Years: 2000-01-01 - 2000-12-31
ID: P0011212
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Purchase of protein Synthesiser for Sequence Selective Drug Design
Years: 2004-07-15 - 2005-07-14
ID: P0014391
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: A PFG indirect detection nano probe for the spectroscopy of bioactive molecules
Years: 2000-01-01 - 2000-12-31
ID: P0012786
Western Researchers: Janice Aldrich-Wright
Funding:
  • Perpetual Trustees Australia Limited (old)
Title: A PFG indirect nano probe for the spectroscopy of bioactive molecules
Years: 1999-11-16 - 2001-12-31
ID: P0012790
Western Researchers: Janice Aldrich-Wright and Mark Williams
Funding:
  • Perpetual Trustees Australia Limited (old)
Title: Mathematical modelling of biomolecular association processes at the Nanoscale
Years: 2004-09-06 - 2005-09-05
ID: P0013684
Western Researchers: Bill Price and Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Characterisation and commercialisation of Bioactives in medical mushrooms
Years: 2005-01-01 - 2007-12-31
ID: P0014445
Western Researchers: John Cairney, Mick Wilson, Kai Yip Cho, Kamali Kannangara, Gary Dennis and Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Characterisation and commercialisation of bioactives in medical mushrooms
Years: 2004-06-21 - 2007-06-20
ID: P0011412
Western Researchers: Mick Wilson, Kai Yip Cho, Kamali Kannangara, Gary Dennis and Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Characterisation of quadruplex DNA motifs by Synchrotron Radiation Circular Dichroism (SRCD)
Years: 2015-06-15 - 2015-06-22
ID: P00022856
Western Researchers: Janice Aldrich-Wright
Funding:
  • Australian Synchrotron Company Ltd
Title: SRCD Characterisation of unusual DNA structures
Years: 2016-06-27 - 2016-07-04
ID: P00023169
Western Researchers: Janice Aldrich-Wright
Funding:
  • Australian Synchrotron Company Ltd
Title: Ultra-High Resolution NMR Imaging System for Nanotechnology including Nanobiotechnology
Years: 2005-01-19 - 2006-06-06
ID: P0014448
Western Researchers: Bill Price, Mick Wilson, Jann Conroy, Peter Williams, Andrew Shalliker, Janice Aldrich-Wright and Kamali Kannangara
Funding:
  • Australian Research Council (non ACRG)
  • University of Western Sydney
  • USYD-UOW-UNEW-UNSW-GRIFU-UMELB-UADE
Title: Effectively Targeting Anticancer Agents
Years: 2008-12-18 - 2009-12-17
ID: P00016471
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: CD DNA binding of platinum (II) intercalating compounds [no funding to UWS]
Years: 2009-07-12 - 2009-07-17
ID: P00016709
Western Researchers: Janice Aldrich-Wright
Funding:
  • Aarhus Universitet
Title: Cell and Protein Analysis Unit
Years: 2009-09-22 - 2010-09-21
ID: P00017371
Western Researchers: Simon Myers, Jens Coorssen, Sabine Piller, Annemarie Hennessy, Janice Aldrich-Wright, Soon Lee and Gerald Muench
Funding:
  • University of Western Sydney
Title: Designing Effective Metallodrugs
Years: 2009-10-28 - 2010-10-27
ID: P00017592
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Fluorescent and Sequence Selective DNA Antibacterial Agents
Years: 2009-12-04 - 2010-12-03
ID: P00017715
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Metallointercalators as Anticancer and Antibacterial Agents
Years: 2008-10-01 - 2012-03-31
ID: P00016174
Western Researchers: Janice Aldrich-Wright, Bill Price and Vincent Higgins
Funding:
  • Department of Industry, Innovation and Science (ACRG)
Title: Novel Spectroscopic Techniques for The Investigation of Membrane Drug Interactions
Years: 2010-05-28 - 2011-05-27
ID: P00018715
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: CD DNA binding of platinum (II) intercalating compounds
Years: 2009-06-25 - 2009-07-17
ID: P00016949
Western Researchers: Janice Aldrich-Wright
Funding:
  • Royal Society of Chemistry
Title: CD DNA binding of platinum (II) intercalating compounds
Years: 2009-07-13 - 2009-07-19
ID: P00016950
Western Researchers: Janice Aldrich-Wright
Funding:
  • Australian Synchrotron Company Ltd
Title: Synchrotron CD Study of a alpha-synuclein in the presence of metal complexes
Years: 2010-07-01 - 2010-07-04
ID: P00018147
Western Researchers: Janice Aldrich-Wright
Funding:
  • Australian Synchrotron Company Ltd
Title: The role of redox balance and reactive oxygen species in beer stability using an integrated transcriptomic and metabolomic analysis
Years: 2007-07-03 - 2011-09-30
ID: P0015191
Western Researchers: Janice Aldrich-Wright
Funding:
  • Australian Research Council (ACRG)
  • University of Western Sydney
  • Fosters Australia Limited
Title: Metallointercalator Antibacterial Agents
Years: 2010-11-30 - 2012-02-29
ID: P00019675
Western Researchers: Janice Aldrich-Wright
Funding:
  • University of Western Sydney
Title: Cost D39 - Non-covalent metallo-drugs working group 2
Years: 2011-06-24 - 2011-07-22
ID: P00020030
Western Researchers: Janice Aldrich-Wright
Funding:
  • Department of Industry, Innovation and Science (nonACRG)
Title: SRCD study of quadruplex DNA and induced effects of metal complexes
Years: 2012-06-25 - 2012-07-01
ID: P00020751
Western Researchers: Janice Aldrich-Wright
Funding:
  • Australian Synchrotron Company Ltd
Title: Branched degradable polymers for anti-cancer drugs delivery
Years: 2011-11-09 - 2012-11-08
ID: P00020491
Western Researchers: Patrice Castignolles, Janice Aldrich-Wright and Mark Jones
Funding:
  • University of Western Sydney
Title: Cost D39 - Non-covalent metallo-drugs working group 2 - Undertake research at Birmingham University and participate in a Circular and Linear Dichroism workshop at the University of Warwick [via Australian Academy of Science]
Years: 2011-11-21 - 2011-12-16
ID: P00020468
Western Researchers: Janice Aldrich-Wright
Funding:
  • Department of Industry, Innovation and Science (nonACRG)
Title: Synchrotron CD Study of proteins and quadraplex DNA in the presence of metal complexes (no funding to UWS)
Years: 2011-06-29 - 2011-07-15
ID: P00020064
Western Researchers: Janice Aldrich-Wright
Funding:
  • Aarhus Universitet
Title: Characterisation of quadraplex DNA motifs by SRCD [no funding to UWS]
Years: 2014-06-23 - 2014-07-01
ID: P00021929
Western Researchers: Janice Aldrich-Wright
Funding:
  • Aarhus Universitet
Title: Analysis of platinum complex-DNA binding interactions via SRCD spectra and melting profiles [no funding to UWS]
Years: 2014-06-23 - 2014-07-01
ID: P00021930
Western Researchers: Janice Aldrich-Wright
Funding:
  • Aarhus Universitet

Supervision

Doctor Aldrich-Wright is available to be a principal supervisor for doctoral projects

Current Supervision

Title: Protection of platinum (II)-based anti cancer complexes
Field of Research:
Title: Structural Requirements for Selective Quadruplex DNA Binding
Field of Research:
Title: Strategies for Delivering Platinum (IV) Prodrugs to Cancer Cells
Field of Research:
Title: Synthesis of Ligands for Anticancer Metallointercallators Using Flow Cytometry
Field of Research:
Title: Finite Nano-Scale Metallosupramolecular Assemblies: Towards Advanced SUper Molecular Materials
Field of Research:
Title: Synthesis of Metallointercalators Metallodrugs
Field of Research:
Title: DNA Recognition and Drug Delivery using Metallo-Supramolecular Assemblies
Field of Research:
Title: Characterisation of the Formation and Biological Impacts of DNA-Addicts caused by the Anti-Cancer Drug Cisplatin and other Clinically Important Platinum-Based Drugs
Field of Research:
Title: Utilising Proteomic Analyses to Investigate the Mechanism of Actions of Platinum(II) DNA-Intercalator Compounds
Field of Research:
Title: Development of [18F]-Fluorine Radiolabelling Methods for Polypyridine Metal Complexes for Evaluation of Bio-Distribution and Therapeutic `Mechanism of Action? Studies
Field of Research:
Title: Synthesis and Biophysical Characterisation of Lanthanide Imaging Agents
Field of Research:
Title: Development fo Polypeptides Based Nanocarrier for Platinum Anticancer Drugs Delivery
Field of Research:
Title: Some Studies of the Molecular and Cellular Interaction of Metallointercalators for Potential Application
Field of Research:
Title: Modification of Copper(II) Complexes and Evaluating Their Anti-Biofilm Potency
Field of Research:
Title: Developing Total Flow Synthetic Protocols to Produce [18F]-fluorine Labelled Pharmaceuticals and Biological Probes
Field of Research:
Title: A Study of Different Forms of Quadraplex DNA and Their Affinity for Planar Molecules
Field of Research:
Title: Conjugated Design Strategies for Pt(IV) Complexes
Field of Research:
Title: The Investigation of Improved Intercalators
Field of Research:
Title: Novel Synthesis and DNA Binding Analyses of Metallodrugs
Field of Research:
Title: Some Studies of the Molecular and Cellular Interaction of Metallointercalators for Potential Application
Field of Research:
Title: Synthesizing Biologically Active Tetradentate Ligands
Field of Research:

Previous Supervision

Title: Synthesis and Characterisation of Platinum (II) and Ruthenium (II) Polyamide Conjugates
Field of Research: BIOMEDICAL ENGINEERING
Thesis: Synthesis and Characterisation of Platinum (II) and Ruthenium (II) Polyamide Conjugates
Title: Synthesis and Analysis of Platinum(II) Sequence Selective Complexes
Field of Research: BIOMEDICAL ENGINEERING
Thesis: <p> Synthesis and Analysis of Platinum(II) Sequence Selective Complexes</p>
Title: Antimicrobial Properties of some Ruthenium(II), Platinum(II), and Copper(II) Metallointercalators
Field of Research: CHEMICAL SCIENCES
Thesis: Antimicrobial Properties of some Ruthenium(II), Platinum(II), and Copper(II) Metallointercalators
Title: Silver (I) helicates and Their Biological Activity
Field of Research: BIOLOGICAL SCIENCES; BIOLOGICAL SCIENCES NOT ELSEWHERE CLASSIFIED; BIOCHEMISTRY AND CELL BIOLOGY
Thesis: Silver (I) helicates and Their Biological Activity
Title: Characterisation of the interactions and biological impacts of cisplatin analogues and metallo-drug complexes with DNA
Field of Research: BIOLOGICAL SCIENCES NOT ELSEWHERE CLASSIFIED
Thesis: Characterisation of the interactions and biological impacts of cisplatin analogues and metallo-drug complexes with DNA
Title: The Design and Biological Interactions of Terpyridineplatinum(II) Bisintercalators as Potential Anticancer Compounds
Field of Research: BIOLOGICAL SCIENCES; CHEMICAL SCIENCES
Thesis: <p> The Design and Biological Interactions of Terpyridineplatinum(II) Bisintercalators as Potential Anticancer Compounds</p>
Title: Characterisation of Chitosan and its Films for Tissue Engineering
Field of Research:
Thesis: Characterisation of Chitosan and its Films for Tissue Engineering
Title: Platinum (II) Metallointercalators as Anticancer Complexes: Synthesis, Biological Testing and Combination Therapy
Field of Research: BIOLOGICAL SCIENCES NOT ELSEWHERE CLASSIFIED
Thesis: Platinum (II) Metallointercalators as Anticancer Complexes: Synthesis, Biological Testing and Combination Therapy
Title: Interactions of Metallointercalators
Field of Research: CHEMICAL SCIENCES NOT ELSEWHERE CLASSIFIED; PHARMACOLOGY; INORGANIC CHEMISTRY
Thesis: Interactions of Metallointercalators

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