Doctor Liza Cubeddu

SENIOR LECTURER - BIOCHEMISTRY,
Medical Science (SoSH)

Personal
Contact
Biography
Publications
Research

Personal

Qualifications

PhD Macquarie University

UWS Organisational Unit (School / Division)

Medical Science (SoSH)

Contact

Email:	L.Cubeddu@uws.edu.au
Extension:	3343
Mobile:
Location:	21.1.02 Campbelltown
Website:

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Biography

Liza Cubeddu is a protein biochemist. She uses a multidisciplinary approach to investigate the biological and structural basis of key processes in DNA repair. Liza obtained her B.Tech (Biotech) Hons in 1998 and her PhD in Biological Chemistry in 2002 from Macquarie University, where she worked on proteins that make up the spliceosome. Liza held a Wellcome Trust International Post-doctoral Research Fellowship at the University of St Andrews (UK), where she commenced her work on DNA repair proteins in a model organism. She returned to Australia in 2006 to take up a National Breast Cancer Foundation Fellowship at the University of Sydney where she shifted her research focus to new human DNA repair proteins; this discovery was published in Nature in 2008.

Liza joined the School of Biomedical and Health Sciences in August 2011 as a Senior Lecturer in Biochemistry and continues to hold an honorary appointment as a Research Fellow at the University of Sydney.

The DNA Repair research group at UWS is a dynamic environment where the main thrust is to understand mechanisms of the DNA damage response and how repair proteins can be developed as useful cancer therapeutics.

This information has been contributed by Doctor Cubeddu.

Publications

Journal Articles

Cubeddu, L., Joseph, S., Richard, D. and Matthews, J. (2012), 'Contribution of DEAF1 Structural Domains to the Interaction with the Breast Cancer Oncogene LMO4', PLoS One, .
Cubeddu, L., Joseph, S., Richard, D. and Matthews, J. (2012), 'Contribution of DEAF1 structural domains to the interaction with the breast cancer oncogene LMO4', PLoS ONE, .
Richard, D., Savage, K., Bolderson, E., Cubeddu, L., So, S. and Ghita, M. (2011), 'hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex', Nucleic Acids Research, 11.
Richard, D., Cubeddu, L., Urquhart, A., Bain, A., Bolderson, E., Menon, D., White, M. and Khanna, K. (2011), 'hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity', Nucleic Acids Research, 9.
Sobti, M., Cubeddu, L., Haynes, P. and Mabbutt, B. (2010), 'Engineered Rings of Mixed Yeast Lsm Proteins Show Differential Interactions with Translation Factors and U-Rich RNA', Biochemistry, 11.
Swarbrick, J., Cubeddu, L., Ball, G., Curmi, P., Gooley, A., Williams, K. and Mabbutt, B. (2009), 'NMR assignment of prespore specific antigen--a cell surface adhesion glycoprotein from Dictyostelium discoideum', Biomolecular NMR Assignments, .
Matthews, J., Bhati, M., Lehtomaki, E., Mansfield, R., Cubeddu, L. and Mackay, J. (2009), 'It takes two to tango: the structure and function of LIM, RING, PHD and MYND domains', Current Pharmaceutical Design, 16.
Richard, D., Pandita, R., Takeda, S., Hay, R., Gautier, J., West, S., Paull, T., Pandita, T., White, M., Khanna, K., Bolderson, E., Cubeddu, L., Wadsworth, R., Savage, K., Sharma, G., Nicolette, M., Tsvetanov, S. and McIlwraith, M. (2008), 'Single-stranded DNA-binding protein hSSB1 is critical for genomic stability', Nature, 5.
Richards, J., Cubeddu, L., Roberts, J., Liu, H. and White, M. (2008), 'The Archaeal XPB Protein is a ssDNA-Dependent ATPase with a Novel Partner', Journal of Molecular Biology, 11.
Cubeddu, L. and Matthews, J. (2008), 'RBBP8 - CtIP', Targeted Proteins Database 1, .
Morgan, H., Estibeiro, P., Wear, M., Max, K., Heinemann, U., Cubeddu, L., Gallagher, M., Sadler, P. and Walkinshaw, M. (2007), 'Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach', Nucleic Acids Research, .
Cubeddu, L. and White, M. (2005), 'DNA damage detection by an archaeal single-stranded DNA-binding protein', Journal of Molecular Biology, .

Conference Papers

Cubeddu, L., Richard, D., White, M. and Khanna, K. (2010), 'Novel single stranded DNA binding proteins crucial for the DNA damage response', 35th FEBS Congress, Gothenburg, Sweden.
Cubeddu, L., Richard, D., Bolderson, E., White, M. and Khanna, K. (2008), 'hSSB1, an evolutionary conserved single stranded DNA binding protein critical for the DNA damage response', 33rd FEBS Congress, .
Cubeddu, L. and Matthews, J. (2007), 'Molecular interactions of LMO4 and DEAF-1: implications for breast cancer', FEBS Conference, .

Research

Understanding the role of the new DNA repair protein hSSB2 in the response to ultraviolet radiation damage (sunlight).
Characterising structure-function relationship of the new DNA repair protein hSSB1 in the MRN repair complex that repairs lethal DNA double-strand breaks.
Exploring the diverse DNA damage response functions of both hSSB1 and hSSB2 and discovering novel binding parthers.