Doctor Mark Temple
LECTURER,
Dean's Unit - School of Sciences and Health
Personal
Qualifications
- PhD University of New South Wales
UWS Organisational Unit (School / Division)
- Dean's Unit - School of Sciences and Health
Contact
| Email: | M.Temple@uws.edu.au |
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| Extension: | 3329 |
| Mobile: | |
| Location: | 21.1.09 Campbelltown |
| Website: |
Biography
Dr Mark Temple is a lecturer in Molecular Biology in the School of Biomedical and Health Sciences at the University of Western Sydney (UWS). During his PhD Mark studied chromatin structure (nucleosome positioning and transcription factor binding) during gene expression and cell cycle progression. In addition he studied the interaction of anti-cancer drugs (including cisplatin and some novel analogues) with DNA in human cells. As a post-doctoral research fellow with Profressor Ian Dawes in the School of Biotechnology and Biomolecular Sciences at University of New South Wales (UNSW), Mark studied ageing and oxidative stress using bakers yeast as a model organism. During the past few years he has become increasingly interested in cell biology, functional genomics and the development of bioinformatics tools for genome-wide dataset analysis.
This information has been contributed by Doctor Temple.
Publications
Journal Articles
- Akand, E., Bain, M. and Temple, M. (2010), 'Learning with gene ontology annotation using feature selection and construction', Applied Artificial Intelligence, 34.
- Fong, C., Temple, M., Alic, N., Chiu, J., Durchdewald, M., Thorpe, G., Higgins, V. and Dawes, I. (2008), 'Oxidant-induced cell-cycle delay in Saccaromyces cerevisiae: the involvement of the SWI6 transcription factor', Fems Yeast Research, 14.
- Drakulic, T., Temple, M., Guido, R., Jarolim, S., Breitenbach, M., Attfield, P. and Dawes, I. (2005), 'Involvement of oxidative stress response genes in redox homeostasis, the level of reactive oxygen species, and ageing in Saccharomyces cerevisiae', FEMS Yeast Extract, 14.
- Temple, M. and Murray, V. (2005), 'Footprinting the 'essential regulatory region' of the retinoblastoma gene promoter in intact human cells', International Journal of Biochemistry and Cell Biology, 14.
- Temple, M., Perrone, G. and Dawes, I. (2005), 'Complex cellular responses to reactive oxygen species', Trends in Cell Biology, 8.
- Alic, N., Felder, T., Temple, M., Gloeckner, C., Higgins, V. and Dawes, I. (2004), 'Genome-wide transcriptional responses to a lipid hydroperoxide: adaptation occurs without induction of oxidant defenses', Free Radical Biology & Medicine, 13.
- Temple, M., Freebody, J. and Murray, V. (2004), 'Genomic and phylogenetic footprinting at the epsilon-globin silencer region in intact human cells', Biochimica et Biophysica Acta - Gene Structure and Expression, 9.
Research
Previous Projects
| Title: | Discovery and prediction of transcriptional regulatory networks important in the cellular responses to oxidative stress. |
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| Years: | 2008-09-24 - 2010-03-31 |
| ID: | P00016348 |
| UWS Researchers: | Mark Temple |
| Funding: |
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Supervision
Doctor Temple is available to be a principal supervisor for doctoral projects
Current Supervision
| Title: | The Formation of DNA Adducts Caused by Cisplatin and other Closely Related Platinum-Based Drugs |
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| Field of Research: |
