Doctor Nikolaus Sucher

Doctor Nikolaus Sucher

CONJOINT PROFESSOR,
School of Medicine

Personal

UWS Organisational Unit (School / Division)

  • School of Medicine

Contact

Email:N.Sucher@uws.edu.au
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Publications

Chapters in Books

  • Lee, B., Carles, M. and Sucher, N. (2008), 'Traditional Chinese herbal medicines for the treatment of cardiovascular diseases', Botanical Medicine in Clinical Practice, CAB International 9781845934132.
  • Lin, D., Loveall, B., Ewer, J., Deitcher, D. and Sucher, N. (2007), 'Characterization of mRNA Expression in Single Neurons', Neuroprotection Methods and Protocols, Humana Press 9781588296665.

Journal Articles

  • Sucher, N. and Muench, G. (2013), 'Cytoprotective properties of traditional Chinese medicinal herbal extracts in hydrogen peroxide challenged human U373 astroglia cells', Neurochemistry International, 8.
  • Diaz, P., Hennell, J. and Sucher, N. (2012), 'Genomic DNA extraction and barcoding of endophytic fungi', Methods in Molecular Biology, 9.
  • Hennell, J., D'Agostino, P., Lee, S., Khoo, C., Sucher, N. and Sucher, N. (2012), 'Using GenBank? for genomic authentication : a tutorial', Methods in Molecular Biology, 20.
  • Bak, T., Nowotny, J., Sucher, N., Sucher, N. and Wachsman, E. (2012), 'Photocatalytic water disinfection on oxide semiconductors. Part 1, Basic concepts of TiO2 photocatalysis', Advances in Applied Ceramics, 12.
  • Sucher, N., Sucher, N., Carles, M., Nowotny, J. and Bak, T. (2012), 'Photocatalytic water disinfection on oxide semiconductors. Part 2, Structure, functional properties and reactivity of macrobial agents', Advances in Applied Ceramics, 18.
  • Govindaraghavan, S., Hennell, J. and Sucher, N. (2012), 'From classical taxonomy to genome and metabolome : towards comprehensive quality standards for medicinal herb raw materials and extracts', Fitoterapia, 10.
  • Sucher, N. (2012), 'DNA fingerprinting, DNA barcoding, and next generation sequencing technology in plants', Methods in Molecular Biology, 10.
  • Sucher, N., Yu, E., Chan, S., Miri, M., Lee, B., Xiao, B., Worley, P. and Jensen, F. (2011), 'Association of the small GTPase Rheb with the NMDA receptor subunit NR3A', NeuroSignals, 7.
  • Bak, T., Nowotny, J., Sucher, N. and Wachsman, E. (2011), 'Effect of crystal imperfections on reactivity and photoreactivity of TiO2 (Rutile) with oxygen, water, and bacteria', Journal of Physical Chemistry C, 28.
  • Qawasmeh, A., Bourke, C., Lee, S., Lee, S., Gray, M., Gray, M., Wheatley, W., Sucher, N., Sucher, N. and Raman, A. (2011), 'GC-MS analysis of volatile secondary metabolites in "mediterranean" and "continental" Festuca arundinacea (Poaceae) infected with the fungal endophyte Neotyphodium coenophialum strain AR542', Acta Chromatographica, 8.
  • Vazhappilly, R., Wee, K., Sucher, N. and Low, C. (2010), 'A non-muscle myosin II motor links NR1 to retrograde trafficking and proteasomal degradation in PC12 cells', Neurochemistry International, 8.
  • Bak, T., Norby, T., Nowotny, A., Nowotny, M. and Sucher, N. (2010), 'Titanium Dioxide Photocatalyst. Unresolved Problems', Solid State Phenomena, 14.
  • Zhou, C., Jensen, F. and Sucher, N. (2009), 'Altered development of glutamatergic synapses in layer V pyramidal neurons in NR3A knockout mice', Molecular and Cellular Neuroscience, 8.
  • Sucher, N. and Carles, M. (2008), 'Genome-based approaches to the authentication of medicinal plants', Planta Medica, 21.
  • Rakhade, S., Zhou, C., Aujla, P., Fishman, R., Sucher, N. and Jensen, F. (2008), 'Early alterations of AMPA receptors mediate synaptic potentiation induced by neonatal seizures', Journal of Neuroscience, 12.
  • Trau, D., Jiang, J. and Sucher, N. (2006), 'Preservation of the biofunctionality of DNA and protein during microfabrication', Langmuir, 5.
  • Fattorusso, R., Frutos, S., Sun, X., Sucher, N. and Pellecchia, M. (2006), 'Traditional Chinese medicines with caspase-inhibitory activity', Phytomedicine, 7.
  • Carles, M. and Sucher, N. (2006), 'Polymerase chain reaction on microchips.', Methods in molecular biology (Clifton, N.J.), 10.
  • Sucher, N. (2006), 'Insights from molecular investigations of traditional Chinese herbal stroke medicines: Implications for neuroprotective epilepsy therapy', Epilepsy and Behavior, 13.
  • Sun, X., Chan, L. and Sucher, N. (2005), 'Magnesium as NMDA receptor blocker in the traditional Chinese medicine Danshen', Phytomedicine, 5.
  • Carles, M., Cheung, M., Moganti, S., Dong, T., Tsim, K., Ip, N. and Sucher, N. (2005), 'A DNA microarray for the authentication of toxic traditional Chinese medicinal plants', Planta Medica, 5.
  • Pi, R., Han, Y., Li, W., Lee, N., Chan, H., Pu, Y., Ling, N., Sucher, N., Chan, D. and Li, M. (2004), 'Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways', Journal of Neurochemistry, 12.
  • Tang, W., Sun, X., Fang, J., Zhang, M. and Sucher, N. (2004), 'Flavonoids from Radix Scutellariae as potential stroke therapeutic agents by targeting the second postsynaptic density 95 (PSD-95)/disc large/zonula occludens-1 (PDZ) domain of PSD-95', Phytomedicine, 8.
  • On, K. and Sucher, N. (2004), 'Molecular interaction of NMDA receptor subunit NR3A with protein phosphatase 2A', NeuroReport, 4.
  • Larn, B., Lo, A., Sum, X., Luo, H., Chung, S. and Sucher, N. (2003), 'Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice', Phytomedicine, 6.
  • Sun, X., Chan, L., Gong, X. and Sucher, N. (2003), 'N-Methyl-D-Aspartate Receptor Antagonist Activity in Traditional Chinese Stroke Medicines', NeuroSignals, 8.
  • Awobuluyi, M., Lipton, S. and Sucher, N. (2003), 'Translationally distinct populations of NMDA receptor subunit NR1 mRNA in the developing rat brain', Journal of Neurochemistry, 10.
  • Cheung, M., Trau, D., Yeung, K., Carles, M. and Sucher, N. (2003), '5-thiolated oligonucleotides on (3-mercaptopropyl)trimethoxysilane-mica: Surface topography and coverage', Langmuir, 5.
  • Chan, V., Carles, M., Sucher, N., Wong, M. and Zohar, Y. (2003), 'Design and fabrication of an integrated microsystem for microcapillary electrophoresis', Journal of Micromechanics and Microengineering, 8.
  • Hau, W., Trau, D., Sucher, N., Wong, M. and Zohar, Y. (2003), 'Surface-chemistry technology for microfluidics', Journal of Micromechanics and Microengineering, 7.
  • Awobulluyi, M., Vazhappilly, R. and Sucher, N. (2003), 'Translational Activity of N-Methyl-D-Aspartate Receptor Subunit NR1 mRNA in PC12 Cells', NeuroSignals, 9.
  • Sucher, N., Guenther, E., Kohler, K., Tenneti, L., Wong, H., Grunder, T., Fauser, S., Wheeler-Schilling, T., Nakanishi, N. and Lipton, S. (2003), 'N-methyl-D-aspartate receptor subunit NR3A in the retina: Developmental expression, cellular localization, and functional aspects', Investigative Ophthalmology and Visual Science, 6.
  • Trau, D., Lee, T., Lao, A., Lenigk, R., Hsing, I., Sucher, N., Ip, N. and Carles, M. (2002), 'Genotyping on a Complementary Metal Oxide Semiconductor Silicon Polymerase Chain Reaction Chip with Integrated DNA Microarray', Analytical Chemistry, 6.
  • Wong, H., Liu, X., Matos, M., Chan, S., Perez-Ota?o, I., Sucher, N., Boysen, M. and + 5 Externals, . (2002), 'The temporal and anatomical expression of NMDA receptor subunit NR3A in the mammalian brain', The Journal of Comparative Neurology, .
  • Vazhappilly, R. and Sucher, N. (2002), 'Turnover analysis of N-methyl-D-aspartate receptor subunit NR1 protein in PC12 cells', Neuroscience Letters, 5.
  • Sasaki, Y., Zhang, D., Nakanishi, N., Sucher, N., Lipton, S., Rothe, T., Premkumar, L., Das, S., Cui, J., Talantova, M., Wong, H., Gong, X. and Chan, S. (2002), 'Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons', Journal of Neurophysiology, 12.
  • Lenigk, R., Carles, M., Ip, N. and Sucher, N. (2001), 'Surface Characterization of a Silicon-Chip-Based DNA Microarray', Langmuir, 5.
  • Chan, S. and Sucher, N. (2001), 'An NMDA Receptor Signaling Complex with Protein Phosphatase 2A', Journal of Neuroscience, 98.
  • Perez-Otano, I., Schulteis, C., Contractor, A., Lipton, S., Trimmer, J., Sucher, N. and Heinemann, S. (2001), 'Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors', Journal of Neuroscience, 10.

Conference Papers

  • Trau, D., Jiang, J. and Sucher, N. (2006), 'Preservation of DNA and protein biofunctionality for bio-MEMS & NEMS fabrication', 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings , .
  • Xu, W., Li, J., Xue, M., Carles, M., Wilhelm Trau, D., Lenigk, R., Sucher, N., Ip, N. and Chan, N. (2002), 'Surface characterization of DNA microarray on silicon dioxide and compatible silicon materials in the immobilization process', Materials Research Society Symposium , .
  • Chan, Y., Ma, R., Carles, M., Sucher, N., Wong, M. and Zohar, Y. (2002), 'DNA kinetics in microfabricated devices', IEEE Micro Electro Mechanical Systems (MEMS) , .
  • Hau, W., Trau, D., Sucher, N., Wong, M. and Zohar, Y. (2002), 'Micro flow patterns on demand using surface-chemistry technology', IEEE Micro Electro Mechanical Systems (MEMS) , .
  • Xue, M., Xu, W., Lu, G., Carles, M., Sucher, N., Ip, N., Ko, P. and Chan, M. (2001), 'A study of the spectral sensitivity of photodiode from a standard CMOS process for DNA detection', International Symposium on IC Technology, Systems and Applications , .
  • Xu, W., Xue, M., Lenigk, R., Carles, M., Sucher, N., Ip, N. and Chan, M. (2001), 'Integrated DNA detection system on silicon substrate with photodiodes', International Symposium on IC Technology, Systems and Applications , .
  • Wen, X., Mei, X., Lenigk, R., Carles, M., Sucher, N., Ip, N. and Chan, M. (2001), 'Characterization of immobilized DNA probes on the surface of silicon compatible materials', IEEE Hong Kong Electron Devices Meeting , .

Research

Current Projects

Title:Strenghtening CompleMED's clinical trials platform through the Evado electronic data capture system, and analytical chemistry instrumentation required for herbal medicine definition.
Years:2010-11-17 - 2013-11-16
ID:P00019350
UWS Researchers:Alan Bensoussan and Nikolaus Sucher
Funding:
  • University of Western Sydney

Previous Projects

Title:Scientifically validated herbal medicines: from bench to bedside: Completion of the infrastructure of the herbal analysis and pharmacology laboratories
Years:2007-08-06 - 2008-08-05
ID:P0015757
UWS Researchers:Nikolaus Sucher and Alan Bensoussan
Funding:
  • University of Western Sydney
Title:Molecular investigations of the neuroprotective activity of estrogen, phytoestrogens, and phytosterols
Years:2009-03-31 - 2012-03-30
ID:P0016089
UWS Researchers:Nikolaus Sucher
Funding:
  • National Health and Medical Research Council (ACRG)
Title:Sucher - Postdoctoral Research Fellow
Years:2006-10-25 - 2011-09-30
ID:P0015377
UWS Researchers:Nikolaus Sucher
Funding:
  • University of Western Sydney
Title:Professorial Chair - Prof Nikolaus Sucher Establishment Grant
Years:2006-10-25 - 2008-12-31
ID:P0015376
UWS Researchers:Nikolaus Sucher
Funding:
  • University of Western Sydney
Title:Establishment of a mass spectrometer facility for natural products and proteomics research and teaching at the College of Health and Science within the University of Western Sydney, Campbelltown campus
Years:2008-09-24 - 2010-09-15
ID:P00016326
UWS Researchers:Nikolaus Sucher, Jens Coorssen, Jens Coorssen, Bill Price, Gerald Muench, Andrew Shalliker, Vincent Higgins, Dennis Chang, Sabine Piller, Simon Myers, Colin Stack and Michelle Moffitt
Funding:
  • University of Western Sydney
Title:Laboratory characterization of Endoherb
Years:2008-11-19 - 2009-12-31
ID:P00016585
UWS Researchers:Cheang Khoo, Nikolaus Sucher, Dennis Chang and Alan Bensoussan
Funding:
  • PT Soho Industri Pharmasi
Title:Molecular effects of Chinese herbal medicines on oxidative stress resistance and ageing in yeast: a functional genomics and phytochemistry approach
Years:2008-12-16 - 2010-01-31
ID:P00016463
UWS Researchers:Nikolaus Sucher
Funding:
  • University of Western Sydney
  • LIPA Pharmaceuticals Ltd
Title:Molecular mechanisms of PS-DHA and Curcumin C3 in hippocampal neurons in vitro (strictly confidential)
Years:2009-11-30 - 2012-12-10
ID:P00017795
UWS Researchers:Nikolaus Sucher and Ray Helliwell
Funding:
  • Abbott Manufacturing Singapore Private Limited
Title:Curcuma Development Project: Stage I
Years:2009-02-19 - 2010-12-31
ID:P00017010
UWS Researchers:Dennis Chang and Nikolaus Sucher
Funding:
  • PT Soho Industri Pharmasi
Title:Molecular characterization of the anti-inflammatory activity of Andrographis paniculata
Years:2010-11-30 - 2012-12-12
ID:P00019633
UWS Researchers:Nikolaus Sucher and Gerald Muench
Funding:
  • University of Western Sydney

Supervision

Doctor Sucher is available to be a principal supervisor for doctoral projects

Previous Supervision

Title:Uptake of Trans-Resveratrol by Yeast Cells
Field of Research:COMPLEMENTARY THERAPIES NOT ELSEWHERE CLASSIFIED
Thesis:Uptake of Trans-Resveratrol by Yeast Cells

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