Doctor Oliver Morton

Doctor Oliver Morton

LECTURER IN MEDICAL MICROBIOLOGY,
Medical Science (SoSH)

Personal

Qualifications

  • PhD Nottingham University

UWS Organisational Unit (School / Division)

  • Medical Science (SoSH)

Contact

Email:O.Morton@uws.edu.au
Extension:3446
Mobile:
Location:21.1.29
Campbelltown
Website:

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Biography

Dr Morton was awarded his PhD in 2002 at the University of Nottingham for research into genetic variation and virulence factors of a nematophagous fungus, Pochonia chlamydosporia, which was being developed as a biological control agent.  In 2004 he moved to the University of St Andrews to conduct a functional genomics project to determine the mode of action of amphibian-derived antimicrobial peptides against Saccharomyces cerevisiae.  From 2007 until late 2011 he worked in the Dept of Clinical Microbiology at Trinity College Dublin studying Invasive Aspergillosis with a focus on developing improved molecular diagnostic tests and examining fungal gene expression in response to host immune cells.

This information has been contributed by Doctor Morton.

Interests

  • Host-Pathogen Interactions
  • Medical Microbiology
  • Mycology

Teaching

Previous Teaching Areas

  • 300321 Microbiology 2, 2012
  • 300826 Medical Microbiology, 2012

Publications

Journal Articles

  • Cronin, L., Moffitt, M., Mawad, D., Morton, O., Lauto, A. and Stack, C. (2013), 'An in vitro study of the photodynamic effect of rose bengal on Trichophyton rubrum.', Journal of Biophotonics, .
  • Morton, O. (2013), 'Combined real-time PCR and galactomannan surveillance improves diagnosis of invasive aspergillosis in high risk patients with haematological malignancies', British Journal of Haematology, 8.
  • Morton, O. (2013), 'Multicenter comparison of serum and whole-blood specimens for detection of Aspergillus DNA in high-risk hematological patients', Journal of Clinical Microbiology, 6.
  • Morton, O., De Luca, A., Romani, L. and Rogers, T. (2012), 'RT-qPCR detection of Aspergillus fumigatus RNA in vitro and in a murine model of invasive aspergillosis utilizing the PAXgene(?) and Tempus? RNA stabilization systems.', Medical Mycology, 6.
  • Morton, O., Bouzani, M., Loeffler, J. and Rogers, T. (2012), 'Direct interaction studies between Aspergillus fumigatus and Human immune cells; what have we learned about pathogenicity and host immunity?', Frontiers in Microbiology, .
  • Morton, O., De Luca, A., Romani, L. and Rogers, T. (2012), 'RT-qPCR detection of Aspergillus fumigatus RNA in vitro and in a murine model of invasive aspergillosis utilizing the PAXgene? and Tempus? RNA stabilization systems', Medical Mycology, 6.
  • Cruciani, M., Mengoli, C., Loeffler, J., Donnelly, P., Barnes, R., Jones, B., Klingspor, L., Morton, O. and Maertens, J. (2012), 'Polymerase chain reaction tests for the diagnosis of invasive aspergillosis in immunocompromised patients (Protocol)', Cochrane Database of Systematic Reviews, .
  • Morton, O., Bouzani, M., Loeffler, J. and Rogers, T. (2012), 'Direct interaction studies between Aspergillus fumigatus and human immune cells; what have we learned about pathogenicity and host immunity?', Frontiers in Microbiology, 7.
  • Springer, J., Einsele, H., Kurzai, O., Loeffler, J., Heinz, W., Schlobnagel, H., Lehmann, M., Morton, O., Rogers, T., Schmitt, C. and Frosch, M. (2011), 'Pathogen-Specific DNA Enrichment Does Not Increase Sensitivity of PCR for Diagnosis of Invasive Aspergillosis in Neutropenic Patients', Journal of Clinical Microbiology, 7.
  • Morton, O., Nierman, W., Rogers, T., Loeffler, J., Varga, J., Hornbach, A., Mezger, M., Sennefelder, H., Kneitz, S., Kurzai, O., Krappmann, S. and Einsele, H. (2011), 'The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro', PL o S One, .
  • Morton, O., Clemons, K., Springer, J., Mueller, J., Rogers, T., Stevens, D., Kurzai, O., Einsele, H. and Loeffler, J. (2011), 'Real-time PCR and quantitative culture for monitoring of experimental Aspergillus fumigatus intracranial infection in neutropenic mice', Journal of Medical Microbiology, 7.
  • Ryan, A., McCarthy, C., O'Brien, J., Ni Eidhin, D., O'Connell, M., Keogh, B., Morton, O., Rogers, T., Fallon, P., O'Neill, L., Kelleher, D., Lynch, M., Loscher, C., Smith, S., Amu, S., Nel, H., McCoy, C., Dowling, J., Draper, E. and O'Reilly, V. (2011), 'A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins', PL o S Pathogens, .
  • Bouzani, M., Ok, M., McCormick, A., Ebel, F., Kurzai, O., Morton, O., Einsele, H. and Loeffler, J. (2011), 'Human NK Cells Display Important Antifungal Activity against Aspergillus fumigatus, Which Is Directly Mediated by IFN-y Release', Journal of Immunology, 8.
  • Morton, O., Loeffler, J., De Luca, A., Frost, S., Kenny, C., Duval, S., Romani, L. and Rogers, T. (2010), 'Dynamics of extracellular release of Aspergillus fumigatus DNA and galactomannan during growth in blood and serum', Journal of Medical Microbiology, 6.
  • Loeffler, J., Morton, O., Mezger, M. and Einsele, H. (2010), 'Genetic polymorphisms in the cytokine and chemokine system: their possible importance in allogeneic stem cell transplantation', Current Topics in Microbiology and Immunology, 14.
  • Morton, O., Hayes, A., Wilson, M., Rash, B., Oliver, S. and Coote, P. (2007), 'Global Phenotype Screening and Transcript Analysis Outlines the Inhibitory Mode(s) of Action of Two Amphibian-Derived, Helical, Cationic Peptides on Saccharomyces cerevisiae', Antimicrobial Agents and Chemotherapy, 12.
  • Morton, O., Dos Santos, S. and Coote, P. (2007), 'An amphibian-derived, cationic, alpha-helical antimicrobial peptide kills yeast by caspase-independent but AIF-dependent programmed cell death', Molecular Microbiology, 14.
  • Morton, O., Hirsch, P. and Kerry, B. (2004), 'Infection of plant-parasitic nematodes by nematophagous fungi - a review of the application of molecular biology to understand infection processes and to improve biological control', Nematology, 10.
  • Morton, O., Mauchline, T., Kerry, R. and Hirsch, P. (2003), 'PCR-based DNA fingerprinting indicates host-related genetic variation in the nematophagous fungus Pochonia chlamydosporia', Mycological Research, 8.
  • Morton, O., Hirsch, P., Peberdy, J. and Kerry, B. (2003), 'Cloning of and genetic variation in protease VCP1 from the nematophagous fungus Pochonia chlamydosporia', Mycological Research, 9.
  • Atkins, S., Hidalgo-Diaz, L., Clark, I., Morton, O., Montes De Oca, N., Gray, P. and Kerry, B. (2003), 'Approaches for monitoring the release of Pochonia chlamydosporia var. catenulata, a biocontrol agent of root-knot nematodes', Mycological Research, 7.

Research

Dr Morton's research is focused on the interaction of pathogenic fungi with host organisms, particularly the adaptation of opportunistic pathogenic fungi to infection of particular hosts. He is also interested in the development of improved molecular diagnostic assays for the detection of invasive fungal infections in humans.

This information has been contributed by Doctor Morton.

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