Doctor Saad Nagi
Adjunct Fellow,
School of Medicine
Biography
Qualifications
- PhD University of Western Sydney
- BMedSc(Hons) University of Western Sydney
- BMedSc University of Western Sydney
Professional Memberships
- International Association for the Study of Pain (2012)
Awards
- Australian Pain Society PhD Student Travel Grant 2013-02-22
- International Association for the Study of Pain Travel Award 2014-05-30
- University of Western Sydney Research Seed Grant Scheme for Early Career Researchers 2013-10-03
- Australian Pain Society PhD Student Travel Grant 2012-03-01
- University of Western Sydney Medal for Outstanding Scholarship 2009-04-22
- Special Interest Group on Neuropathic Pain (International Association for the Study of Pain) Congress Bursary Award 2013-01-31
- International Association for the Study of Pain Early Career Research Grant 2014-05-01
Organisational Unit (School / Division)
- School of Medicine
Committees
- UWS School of Medicine Research Committee
Contact
Email: | S.Nagi@westernsydney.edu.au |
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Phone: | (02) 4620 3496 |
Mobile: | 0401740870 |
Location: | 30.2.32 Campbelltown |
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Publications
Journal Articles
- Thorell, O., Ydrefors, J., Svantesson, M., Gerdle, B., Olausson, H., Mahns, D. and Nagi, S. (2023), 'Investigations into an overlooked early component of painful nociceptive withdrawal reflex responses in humans', Frontiers in Pain Research, vol 3 .
- Dunn, J., Nagi, S. and Mahns, D. (2020), 'Minocycline reduces experimental muscle hyperalgesia induced by repeated nerve growth factor injections in humans : a placebo-controlled double-blind drug-crossover study', European Journal of Pain, vol 24, no 6 , pp 1138 - 1150.
- Ridderstrom, M., Svantesson, M., Thorell, O., Magounakis, T., Minde, J., Olausson, H. and Nagi, S. (2020), 'High prevalence of carpal tunnel syndrome in individuals with rare nerve growth factor-beta mutation', Brain Communications, vol 2, no 2 .
- Dunn, J., Mahns, D. and Nagi, S. (2020), 'Modulation of muscle pain is not somatotopically restricted : an experimental model using concurrent hypertonic-normal saline infusions in humans', Frontiers in Pain Research, vol 1 .
- Nagi, S., Marshall, A., Makdani, A., Jarocka, E., Liljencrantz, J., Ridderstrom, M., Shaikh, S., O?Neill, F., Saade, D., Donkervoort, S., Reghan Foley, A., Minde, J., Trulsson, M., Cole, J., Bonnemann, C., Chesler, A., Bushnell, M., McGlone, F. and Olausson, H. (2019), 'An ultrafast system for signaling mechanical pain in human skin', Science Advances, vol 5, no 7 .
- Birznieks, I., McIntyre, S., Nilsson, H., Nagi, S., Macefield, V., Mahns, D. and Vickery, R. (2019), 'Tactile sensory channels over-ruled by frequency decoding system that utilizes spike pattern regardless of receptor type', eLife, vol 8 .
- Dunn, J., Mahns, D. and Nagi, S. (2017), 'Why does a cooled object feel heavier? Psychophysical investigations into the Weber's Phenomenon', BMC Neuroscience, vol 18 .
- Liljencrantz, J., Strigo, I., Ellingsen, D., Kramer, H., Lundblad, L., Nagi, S., Leknes, S. and Olausson, H. (2017), 'Slow brushing reduces heat pain in humans', European Journal of Pain, vol 21, no 7 , pp 1173 - 1185.
- Samour, M., Nagi, S., Shortland, P. and Mahns, D. (2017), 'Minocycline prevents muscular pain hypersensitivity and cutaneous allodynia produced by repeated intramuscular injections of hypertonic saline in healthy human participants', The Journal of Pain, vol 18, no 8 , pp 994 - 1005.
- Nagi, S., Dunn, J., Birznieks, I., Vickery, R. and Mahns, D. (2015), 'The effects of preferential A- and C-fibre blocks and T-type calcium channel antagonist on detection of low-force monofilaments in healthy human participants', BMC Neuroscience, vol 16, no 1 .
- Shaikh, S., Nagi, S., McGlone, F. and Mahns, D. (2015), 'Psychophysical investigations into the role of low-threshold C fibres in non-painful affective processing and pain modulation', PLoS One, vol 10, no 9 .
- Samour, M., Nagi, S. and Mahns, D. (2015), 'Cav3.2-expressing low-threshold C fibres in human hairy skin contribute to cold allodynia : a non-TRPV1- and non-TRPM8-dependent phenomenon', Pain, vol 156, no 8 , pp 1566 - 1575.
- Nagi, S. and Mahns, D. (2013), 'C-tactile fibers contribute to cutaneous allodynia after eccentric exercise', Journal of Pain, vol 14, no 5 , pp 538 - 548.
- Mahns, D. and Nagi, S. (2013), 'An investigation into the peripheral substrates involved in the tactile modulation of cutaneous pain with emphasis on the C-tactile fibres', Experimental Brain Research, vol 227, no 4 , pp 457 - 465.
- Nagi, S. and Mahns, D. (2013), 'Mechanical allodynia in human glabrous skin mediated by low-threshold cutaneous mechanoreceptors with unmyelinated fibres', Experimental Brain Research, vol 231, no 2 , pp 139 - 151.
- Nagi, S., Rubin, T., Chelvanayagam, D., Macefield, V. and Mahns, D. (2011), 'Allodynia mediated by C-tactile afferents in human hairy skin', Journal of Physiology, vol 589, no 16 , pp 4065 - 4075.
What triggers the crossover between non-painful and painful sensations is yet to be fully elucidated especially in clinical pain states such as allodynia, i.e. pain evoked by otherwise non-painful stimuli. Saad's research interests revolve around the mechanisms underlying touch, temperature and pain, the interplay of these sensations in healthy and clinical states, the contribution of different peripheral nerve fibres in coding of stimulus features, and the role of cognitive influences in pain modulation. Recent investigations have demonstrated that a class of low-threshold unmyelinated afferent nerve fibres, dubbed C-tactile fibres, mediates the crossover between pleasurable-touch and painful-touch in experimental pain conditions, thereby unveiling a novel substrate of tactile allodynia. Further investigations are under way with the aim of determining the response properties, chemical phenotype and innervation pattern of this afferent class, in addition to testing their contributions in clinical pain conditions.
This information has been contributed by Doctor Nagi.
Previous Projects
Title: | A novel substrate of pain in humans |
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Funder: |
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Western Researchers: | Saad Nagi and John Morley |
Years: | 2013-09-09 - 2015-03-09 |
ID: | P00021752 |
Title: | Role of C-tactile Fibres in Pain Processing: Experimental and Clinical Investigations |
Funder: |
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Western Researchers: | Saad Nagi |
Years: | 2014-05-31 - 2015-05-31 |
ID: | P00022261 |
Supervision
Doctor Nagi is available to be a principal supervisor for doctoral projects
Previous Supervision
Thesis Title: | Allodynia: Mechanisms and Treatment |
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Field of Research: | Medical Science; Other Health |
Thesis Title: | Experimentally Induced Muscoskeletal Pain: a Tool for Understanding Chronic Pain |
Field of Research: | Medical Studies |
Media
Title: | Real-world medical research takes the pain out of life |
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Description: | Article on Medical Research and its real-world application - published in The Sydney Morning Herald |