Doctor Srinivas Nammi

LECTURER - PHARMACOLOGY,
Medical Science (SoSH)

Personal
Contact
Biography
Publications
Research
Teaching

Personal

Qualifications

PhD Andhra University (India)
Master of Science Andhra University (India)
BSc(Pharm) Andhra University (India)

UWS Organisational Unit (School / Division)

Medical Science (SoSH)

Contact

Email:	S.Nammi@uws.edu.au
Extension:	3038
Mobile:
Location:	21.1.23 Campbelltown
Website:

Biography

Dr Srinivas Nammi has a doctorate in Pharmaceutical Sciences, specialising in Pharmacology. Before joining the University of Western Sydney as a lecturer in Pharmacology, Dr Nammi worked at the University of Sydney for three years and at the University of Canberra for one year.

Dr Nammi has completed all his academic degrees at Andhra University, in the Faculty of Pharmaceutical Sciences, India. Since completing his PhD in 2003, he has gained extensive postdoctoral experience at the University of Tubingen, Germany and at the University of Manitoba, Canada.

Dr Nammi has worked as an Industrial Pharmacologist for a year where he was closely associated with the establishment of a Pharmacology research laboratory. He has an excellent track record in herbal medicines research and made significant contribution to both basic and applied research related to drug discovery, biological evaluation and mechanistic studies with special focus on metabolic disorders. He has published 42 scientific papers with more than 450 research citations and contributed to over 30 conference abstracts.

This information has been contributed by Doctor Nammi.

Interests

Fatty Liver Disease
Herbal Pharmacology
Insulin Resistance
Lipid Disorders
Metabolic Syndrome
Obesity
Pharmacokinetics and Drug Interactions
Type 2 Diabetes and its Complications

Awards

Sesquicentenary (SESQUI) University of Sydney Postdoctoral Fellowship, Australia 2006-07-07
Deutscher Akademischer Austausch Dienst (DAAD) Fellowship, Germany 2003-06-10
Council of Scientific and Industrial Research (CSIR) Senior Research Fellowship, India 1999-10-01
Best Presentation Award, Seminar on Pharmaceutical Research in the New Millennium , India 2002-05-01
Best Paper Award, 52nd Indian Pharmaceutical Congress, India 2000-12-03
Graduate Aptitude Test in Engineering (GATE) Fellowship, India 1996-03-31

Teaching

Previous Teaching Areas

300361 Introduction to Human Biology, 2012
300505 Pharmacology, 2011
300505 Pharmacology, 2012

Publications

Chapters in Books

Chang, D., Nammi, S. and Grant, S. (2012), 'Traditional Understanding, Modern Science and Usage of Herbal Medicines for Diabetes', Innovation in Healthy and Functional Foods, Taylor & Francis 9781439862674.
Chang, D., Nammi, S. and Grant, S. (2012), 'Traditional understanding, modern science, and usage of herbal medicines for diabetes', Innovation in Healthy and Functional Foods, CRC Press 9781439862674.
Li, G., Ravnovski-Naumovski, V., Omar, E., Teoh, A., Song, M., Tongao-On, W., Nammi, S. and Mo, S. (2010), 'Evaluation of Biological Activity and Quality Control of Herbal Medicines', Bioactive Natural Products, Studium Press .

Journal Articles

Kam, A., Li, K., Naumovski, V., Nammi, S., Chan, K., Li, Y. and Li, G. (2012), 'The protective effects of natural products on blood-brain barrier breakdown', Current Medicinal Chemistry, 16.
Li, X., McGrath, K., Nammi, S., Heather, A. and Roufogalis, B. (2012), 'Attenuation of liver pro-inflammatory responses by Zingiber officinale via inhibition of NF-kappaB activation in high-fat diet-fed rats', Basic & Clinical Pharmacology & Toxicology, 7.
Kam, A., Li, K., Razmovski-Naumovski, V., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. (2012), 'Combination of TNF-a, homocysteine and adenosine exacerbated cytotoxicity in human cardiovascular and cerebrovascular endothelial cells', Cellular Physiology and Biochemistry, 10.
Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Nammi, S., Chan, K. and Li, G. (2012), 'Combination of TNF-a, homocysteine and adenosine exacerbated cytotoxicity in human cardiovascular and cerebrovascular endothelial cells', Cellular Physiology and Biochemistry, 10.
Li, X., McGrath, K., Nammi, S., Heather, A. and Roufogalis, B. (2012), 'Attenuation of liver pro-inflammatory responses by Zingiber officinale via inhibition of NF-kappa B activation in high-fat diet-red rats', Basic and Clinical Pharmacology and Toxicology, 7.
Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K., Li, Y. and Li, G. (2012), 'The protective effects of natural products on blood-brain barrier breakdown', Current Medicinal Chemistry, 16.
Omar, E., Kam, A., Alqahtani, A., Li, K., Naumovski, V., Nammi, S., Chan, K., Roufogalis, B. and Li, G. (2010), 'Herbal medicines and nutraceuticals for diabetic vascular complications: mechanisms of action and bioactive phytochemicals', Current Pharmaceutical Design, 32.
Nammi, S., Kim, M., Gavande, M., Li, G. and Roufogalis, B. (2010), 'Regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme-A reductase expression by Zingiber officinale in the liver of high-fat diet-fed rats.', Basic & Clinical Pharmacology & Toxicology, 7.
Nammi, S., Sreemantula, S. and Roufogalis, B. (2009), 'Protective effects of ethanolic extract of Zingiber officinale rhizome on the development of metabolic syndrome in high fat diet-fed rats.', Basic & Clinical Pharmacology & Toxicology, 8.
Boini, K., Nammi, S., Grahammer, F., Osswald, H., Kuhl, D. and Lang, F. (2008), 'Role of serum & glucocorticoid inducible kinase sgk1 in glucocorticoid regulation of renal electrolyte excretion and blood pressure', Kidney and Blood Pressure Research, 10.
Nammi, S., Dembele, K. and Nyomba, B. (2007), 'Increased 11a-hydroxysteroid dehydrogenase type-1 and hexose-6-phosphate dehydrogenase in liver and adipose tissue of rat offspring exposed to alcohol in utero.', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 9.
Rexhepaj, F., Grahammer, F., Volkl, H., Remy, C., Wagner, C., Sadulache, D., Artunc, F. and Nammi, S. (2006), 'Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice', FASEB Journal, 9.
Sushruta, K., Satyanarayana, S., Nammi, S. and Rajasekhar, J. (2006), 'Evaluation of the Blood-Glucose Reducing Effects of Aqueous Extracts of the Selected Umbelliferous Fruits Used in Culinary Practices', Tropical Journal of Pharmaceutical Research, 5.
Rao, N. and Nammi, S. (2006), 'Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats', BMC Complementary and Alternative Medicine, .
Sandu, C., Rexhepaj, R., Grahammer, F., Mccormick, J., Henke, G., Palmada, M., Nammi, S. and Lang, U. (2005), 'Decreased Intestinal Glucose Transport in the sgk3-knockout Mouse', Pfluger's Archiv European Journal of Physiology, 8.
Nammi, S. (2005), 'Ayurveda and Diabetes', Physician's Digest, 7.
Nammi, S., Boini, K., Koppula, S. and Sreemantula, S. (2005), 'Reserpine-Induced Central Effects: Pharmacological Evidence for the Lack of Central Effects of Reserpine Methiodide', Canadian Journal of Physiology and Pharmacology, 7.
Sandulache, S., Grahammer, F., Nammi, S., Artunc, F., Mack, A., Huang, D., Vallon, V. and Wulff, P. (2005), 'Renal Ca2+ handling in the sgk1 knockout mouse', Pfluger's Archiv European Journal of Physiology, .
Artunc, F., Grahammer, F., Sadulache, D., Bohmer, D., Palmada, M., Henke, G., Nammi, S. and Mack, A. (2005), 'Impaired intestinal amino acid absorption in PDK1 deficient mice', Pflugers Archiv European Journal of Physiology, 1.
Sreemantula, S., Boini, K., Koppula, S., Kilari, E. and Nammi, S. (2005), 'Indirect biochemical evidence that reserpine methiodide produces selective depletion of peripheral biogenic amines in rats', Die Pharmazie, 4.
Sreemantula, S., Nammi, S., Kolanukonda, R., Koppula, S. and Boini, K. (2005), 'Adaptogenic and nootropic activities of aqueous extract of Vitis vinifera (grape seed): an experimental study in rat model', BMC Complementary and Alternative Medicine, .
Rao, P., Nammi, S., Routhu, K. and Raju, A. (2005), 'The antimicrobial activity of Heliotropium indicum Linn. in in vitro assay', Asia Pacific Journal of Pharmacology, 2.
Nalamolu, R., Boini, K. and Nammi, S. (2004), 'Effect of chronic administration of Boerhaavia diffusa Linn. leaf extract on experimental diabetes in rats.', Tropical Journal of Pharmaceutical Research, 5.
Rao, N., Annapurna, M., Boini, K. and Nammi, S. (2004), 'Antidiabetic Activity of Boerhaavia diffusa L. leaf extract in streptozotocin-Induced IDDM model rats', Asia Pacific Journal of Pacific Journal of Pharmacology, 4.
Sreemantula, S., Boini, K. and Nammi, S. (2004), 'Reserpine methonitrate, a novel quaternary analogue of reserpine augments urinary excretion of VMA and 5-HIAA without affecting HVA in rats', BMC Pharmacology, .
Satyanarayana, S., Sushruta, K., Sarma, G., Nammi, S. and Subbaraju, G. (2004), 'Antioxidant activity of the aqueous extracts of spicy food additives - evaluation and comparison with ascorbic acid in in-vitro systems', Journal of Herbal Pharmacotherapy, 10.
Nammi, S., Boini, K., Kilari, E. and Sreemantula, S. (2004), 'Pharmacological evidence for lack of central effects of reserpine methonitrate: A novel quaternary analog of reserpine', Therapy, 9.
Birka, C., Krikov, M., Huber, S., Wieder, T., Lang, F., Lang, P., Kempe, D., Hoefling, L., Tanneur, V., Duranton, C., Nammi, S., Henke, G. and Myssina, S. (2004), 'Enhanced Susceptibility of Erythrocyte Apoptosis following Phosphate Depletion', Pfluger's Archiv European Journal of Physiology, 7.
Nammi, S., Koka, S., Chinnala, K. and Boini, K. (2004), 'Obesity: An overview on its current perspectives and treatment options', Nutrition Journal, 1.
Krishna, M., Nammi, S., Kota, M., Rao, N., Rao, R. and Annaa, A. (2004), 'Evaluation of hypoglycemic and antihyperglycemic effects of Datura metel (Linn.) seeds in normal and alloxan-induced diabetic rats', Journal of Ethnopharmacology, 4.
Sudhakar, M., Rao, C., Rao, A., Ramesh, A., Nammi, S., Raju, D. and Krishna, M. (2004), 'Antinociceptive and anti-inflammatory effects of the standardized oil of Indian Callistemon tanceolatus leaves in experimental animals', East Central African Journal of Pharmaceutical Sciences, 7.
Satyanarayana, S., Sarma, G., Ramesh, A., Sushruta, K. and Nammi, S. (2003), 'Evaluation of herbal preparations for hypoglycemic activity in normal and diabetic rabbits', Pharmaceutical Biology, 7.
Nammi, S., Gudavalli, R., Babu, B., Lodagala, D. and Boini, K. (2003), 'Possible mechanisms of hypotension produced by 70% alcoholic extract of Terminalia arjuna in anaesthetized dogs.', BMC Complementary and Alternative Medicine, .
Nammi, S., Boini, K., Lodagala, D. and Babu, B. (2003), 'The juice of fresh leaves of Catharanthus roseus Linn. reduces blood flucose in normal and alloxan diabetic rabbits.', BMC Complementary and Alternative Medicine, .
Nammi, S., Ganti, S., Lodagala, D. and Babu, B. (2003), 'Hypoglycemic and insulin release effects of Hugonia mystax in rabbits', Asia Pacific Journal of Pharmacology, 3.
Rao, P., Babu, D., Rao, R. and Nammi, S. (2002), 'Comparative study of sweet and bitter varieties of Aegle marmelos (L.) Correa for hypoglycemic activity in rabbits.', Journal of Natural Remedies, 4.
Rao, P., Nammi, S. and Raju, A. (2002), 'Studies on the antimicrobial activity of Heliotropium indicum', Journal of Natural Remedies, 4.
Annapurna, A., Kumar, K., Rambabu, G. and Nammi, S. (2001), 'Ceramide: A novel second messenger', Proceedings of Indian National Science Academy, 10.
Nammi, S., Ganti, S. and Lodagala, D. (2001), 'Hypoglycemic effect of Aegle marmelos leaf extract on normal and diabetic model rabbits.', Asia Pacific Journal of Pharmacology, 3.

Conference Papers

Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. (2012), 'Multivariant analyses of the geographical variability in the polyphenolic content and antioxidant capacities of pomegranate peel', Good Practice in Traditional Chinese Medicine Research (GP-TCM Congress) in the Post-genomic Era, Leiden, The Netherlands.
Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. (2012), 'Intercontinental variability in the polyphenolic profile and antioxidant capacity of pomegranate peel', 11th Annual Oxford International Conference on the Science of Botanicals (ICSB), .
Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. (2012), 'Protective effects of pomegranate peel against endothelial cell death caused by homocysteine, adenosine and TNF-alpha', Consortium for Globalization of Chinese Medicine (CGCM), Macau.
Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. (2012), 'Intercontinental Variability in the Polyphenolic Profile and Total Antioxidant Capacity of Pomegranate Peel', 11th Annual Oxford International Conference on the Science of Botanicals (ICBS), Oxford, Mississippi.
Roufogalis, B., Nammi, S., Li, X., Mcgrath, K., Heather, A., Li, Y., Tran, A. and Duke, C. (2011), 'Ginger- A Spice with New Life in Diabetes and Metabolic Syndrome', 3rd Australia-China Biomedical Research Conference (ACBRC), Melbourne, Australia.
Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. (2011), 'Polyphenolic profile and antioxidant capacity of dried pomegranate peel: Influences of geographical origin', International forum on evidence based integration of Traditional Chinese Medicine (TCM) in Australia, .
Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. (2011), 'Polyphenolic profile of pomegranate peel: Influences of geographical origin', Consortium for Globalization of Chinese Medicine (CGCM), .
Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. (2010), 'Inhibitory effects of pomegranate fruit and flower on intestinal carbohydrate digestive enzymes', Bosch Institute Young Investigators Symposium, Sydney, Australia.
Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. (2010), 'Identification of phenolic compounds for the inhibitory effects of pomegranate flower on f?-amylase and f?-glucosidase activities', Australasian Pharmaceutical Science Association (APSA) Annual Conference, Brisbane, Australia.
Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. (2010), 'The inhibitory activities of pomegranate on carbohydrate digestive enzymes: a-glucosidase and a-amylase.', 9th Consortium for Globalization of Chinese Medicine (CGCM), Hong Kong.
Nammi, S. (2008), 'An holistic approach in the management of metabolic syndrome', 1st International Euro-India Conference on Holistic Medicine1st International Euro-India Conference on Holistic Medicine, Kottayam, India.
Nammi, S. and Roufogalis, B. (2008), 'Protective effects of Zingiber officinale extract on the development of metabolic syndrome in high fat diet-fed rats', 3rd International Congress on Complementary Medicine Research, Sydney, Australia.
Friedrich, B., Grahammer, F., Sandulache, D., Artunc, F., Henke, G., Rexhepaj, R., Nammi, S. and Alessi, D. (2005), 'Renal function of PDK1 hypomorphic mice', 36th Kongress der Gesellschaft fur Nephrologie, Saarbruken, Germany.
Boini, K., Annapurna, A., Kota, M., Rao, R. and Nammi, S. (2004), 'Hypoglycemic and antihyperglycemic effects of a polyherbal formulation (RVF1) in normal and alloxan-induced diabetic rats', Proceedings of AP Academy of Sciences, .
S, S., Nammi, S. and B, K. (2004), 'Adaptogenic activity of Withania somnifera aqueous extract by employing biochemical approach in experimental rats.', 56th Indian Pharmaceutical Congress, Kolkata, India.
Nammi, S., Birka, C., Lang, P., Kempe, D., Hoefling, L., Tanneur, V., Duranton, C. and Henke, G. (2004), 'Enhanced susceptibility of erythrocyte apoptosis following phosphate depletion', 83rd Annual Meeting of Duetsche Physiologische Gesellschaft, Leipzig, Germany.
S, S., Nammi, S., K, S. and B, K. (2003), 'Peripheral action of reserpine analogues: Evaluation by pharmacological and biochemical methods', 55th Indian Pharmaceutical Congress, Chennai, India.
S, S., B, K., Nammi, S. and K, S. (2003), 'Evaluation of adaptogenic activity of grape seed extract (GSE) employing biochemical approach in rats.', 55th Indian Pharmaceutical Congress, Chennai, India.
S, S., B, K., Nammi, S. and K, S. (2003), 'Evaluation of aqueous Umbelliferous fruit extracts for nootropic activity using conditioned avoidance response (CAR) in rats.', 55th Indian Pharmaceutical Congress, Chennai, India.
S, S., Nammi, S. and B, K. (2003), 'Synthesis and biological evaluation of quaternary analogues of reserpine', National Seminar on Pharmaceutical Research: Present and Future Perspectives, Visakhapatnam, India.
Nammi, S. (2002), 'Synthesis and Pharmacological Evaluation of Non-Sedative Reserpine Analogues for Antihypertensive Activity', 54th Indian Pharmaceutical Congress, Pune, India.
Nammi, S. and Koppula, S. (2002), 'Synthesis and CNS Activity of Quaternary Derivatives of Reserpine', Seminar on Pharmaceutical Research in the New Millennium, Visakhapatnam, India.
Koppula, S. and Nammi, S. (2002), 'Antioxidant Activity of Spicy Food Additives', Seminar on Pharmaceutical Research in the New Millennium, Visakhapatnam, India.
Nammi, S. and Ganti, S. (2002), 'Biochemical Evidence for Adaptogenic Activity of Selected Plant Extracts', Seminar on Pharmaceutical Research in the New Millennium, Visakhapatnam, India.
Nammi, S. and S, S. (2002), 'Synthesis and Pharmacological Evaluation of Non-Sedative Reserpine Analogs for Antihypertensive Activity', Dr. KV Rao Scientific Society, Hyderabad, India.
Nammi, S., D, M. and S, S. (2001), 'Losartan Interaction with Metformin in Diabetic Rabbits', 53rd Indian Pharmaceutical Congress, New Delhi, India.
Nammi, S., D, S. and S, S. (2001), 'Influence of Homeopathic Drug on Urinary Biochemical Changes in Normal and Stress Induced Rats', 53rd Indian Pharmaceutical Congress, New Delhi, India.
Nammi, S. and S, S. (2001), 'Evaluation of Herbal Preparations for Hypoglycemic Activity in Normal and Diabetic Rabbits', Seminar on Evaluation of Herbal Antidiabetic Drugs, Chennai, India.

Research

Dr Srinivas Nammi has over 15 years of experience in pharmacological research in the areas of endocrine and cardiovascular pharmacology through working on various projects in academic and industrial setting with special focus on the cause and treatment of metabolic syndrome and type 2 diabetes. He has a distinguished track record in herbal medicines research and made significant contribution to both basic and applied research related to drug discovery, biological evaluation and mechanistic studies using various pharmacological and molecular biology methods. So far, Dr Nammi has supervised four master student projects, four honours student projects, three advanced student projects, and four summer student projects.

He is also interested in the following reseach areas:

Pathophysiological mechanisms and therapeutic interventions involved in: Insulin resistance, obesity and type-2 diabetes. Beta-cell dysfunction and Diabetes mellitus. Glucocorticoid excess and metabolic syndrome with special focus on 11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1).
Evaluation and identification of mechanism(s) of action of traditional herbal medicines in the treatment/prevention of: Obesity, Type 2 diabetes and its complications, Lipid disorders, Cardiovascular diseases and Oxidative stress
Mechanisms involved in low, moderate and heavy alcohol consumption (prenatal and postnatal) on the development of: Fatty Liver Disease, Metabolic syndome and Type 2 diabetes
Pharmacokinetics and drug interactions - Pharmacokinetic evaluation of traditional herbal medicines to discover biologically active compounds for the treatment of metabolic syndrome and type 2 diabetes: drug-drug interactions and Herb-drug interactions