Professor Gerald Muench

Journal Articles

• Ravipati, A., Wu, M., Satyanarayanan, M., Vysetti, B., Zhang, L., Koyyalamudi, S., Koyyalamudi, S., Jeong, S., Jeong, S., Reddy, N., Bartlett, J., Smith, P., Smith, P., Shanmugam, K. and Muench, G. (2012), 'Antioxidant and Anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content', BMC Complementary and Alternative Medicine, 24.
• Wild, R., Ooi, L., Srikanth, V. and Muench, G. (2012), 'A quick, convenient and economical method for the reliable determination of methylglyoxal in millimolar concentrations : the N-acetyl-L-cysteine assay', Analytical and Bioanalytical Chemistry, 5.
• Steele, M., Ooi, L. and Muench, G. (2012), 'Development of a high-performance liquid chromatography method for the simultaneous quantitation of glutathione and related thiols', Analytical Biochemistry, 8.
• Ravipati, A., Wu, M., Satyanarayanan, M., Vysetti, B., Zhang, L., Koyyalamudi, S., Jeong, S., Reddy, N., Bartlett, J., Smith, P., Shanmugam, K. and Muench, G. (2012), 'Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content', BMC Complementary and Alternative Medicine, 14.
• Muench, G., Westcott, B., Menini, T. and Gugliucci, A. (2012), 'Advanced glycation endproducts and their pathogenic roles in neurological disorders', Amino Acids, 16.
• Zhang, L., Wu, M., Ravipati, A., Koyyalamudi, S., Jeong, S., Reddy, N., Smith, P., Bartlett, J., Shanmugam, K. and Muench, G. (2011), 'Antioxidant and anti-inflammatory activities of selected medicinal plants containing phenolic and flavonoid compounds', Journal of Agricultural and Food Chemistry, 7.
• Sauer, T., Raithel, M., Kressel, J., Muscat, S., Muench, G. and Pischetsrieder, M. (2011), 'Nuclear translocation of NF-kB in intact human gut tissue upon stimulation with coffee and roasting products', Food and Function, 12.
• Rahmadi, A., Steiner, N. and Muench, G. (2011), 'Advanced glycation endproducts as gerontotoxins and biomarkers for carbonyl-based degenerative processes in Alzheimer's disease', Clinical Chemistry and Laboratory Medicine, 7.
• Krautwald, M., Leech, D., Horne, S., Steele, M., Forbes, J., Rahmadi, A., Griffith, R. and Muench, G. (2011), 'The advanced glycation end product-lowering agent ALT-711 Is a Low-Affinity inhibitor of thiamine Diphosphokinase', Rejuvenation Research, 9.
• Srikanth, V., Maczurek, A., Phan, T., Steele, M., Westcott, B., Juskiw, D. and Muench, G. (2011), 'Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease', Neurolbiol Aging, 15.
• Zhang, L., Wu, M., Ravipati, A., Koyyalamudi, S., Koyyalamudi, S., Reddy, N., Jeong, S., Reddy, N., Reddy, N., Smith, P., Smith, P., Bartlett, J., Munch, G., Bartlett, J., Muench, G., Wu, M., Shanmugam, K. and Muench, G. (2011), 'Antioxidant and Anti-inflammatory Activities of Extracts of Selected Medicinal Plants Containing Phenolic and Flavonoid compounds', Journal of Agricultural and Food Chemistry, 7.
• Zhang, L., Wu, M., Ravipati, A., Koyyalamudi, S., Koyyalamudi, S., Reddy, N., Jeong, S., Reddy, N., Reddy, N., Smith, P., Smith, P., Bartlett, J., Munch, G., Bartlett, J., Muench, G., Wu, M., Shanmugam, K. and Muench, G. (2011), 'Antioxidant and Anti-inflammatory Activities of Extracts of Selected Medicinal Plants Containing Phenolic and Flavonoid compounds', Journal of Agricultural and Food Chemistry, 7.
• Vallotton, P., Sun, C., Lovell, D., Savelsbergh, M., Payne, M., Muench, G. and Muench, G. (2011), 'Identifying weak linear features with the "coalescing shortest path image transform"', Microscopy and Microanalysis, 4.
• Stutchbury, G. and Muench, G. (2010), 'Optimizing the generation of stable neuronal cell lines via pre-transfection restriction enzyme digestion of plasmid DNA', Cytotechnology, 6.
• Krautwald, M. and Muench, G. (2010), 'Advanced glycation end products as biomarkers and gerontotoxins - A basisto explore methylglyoxal-lowering agents for Alzheimer's disease?', Experimental Gerontology, 8.
• Hansen, E., Korner, H., Muench, G., Krautwald, M., Maczurek, A., Stutchbury, G., Fromm, P., Steele, M., Schulz, O., Garcia, O. and Castillo, J. (2010), 'A versatile high throughput screening system for the simultaneous identification of anti-inflammatory and neuroprotective compounds', Journal of Alzheimer's Disease, 14.
• Chandler, D., Muench, G., Woldu, A., Woldu, A., Rahmadi, A., Shanmugam, K., Steiner, N., Wright, E., Benavente-Garcia, O., Schulz, O. and Castillo, J. (2010), 'Effects of plant-derived polyphenols on TNF-alpha and nitric oxide production induced by advanced glycation endproducts', Molecular Nutrition and Food Research, 10.
• Fuller, S., Steele, M. and Muench, G. (2010), 'Activated astroglia during chronic inflammation in Alzheimer's disease - do they neglect their neurosupportive roles?', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 10.
• Muscat, S., Pischetsrieder, M., Maczurek, A., Rothemund, S. and Muench, G. (2009), 'Cytotoxicity of Maillard reaction products determined with a peptide spot library', Mol Nutr Food Res, 11.
• Krautwald, M., Maxwell, P., Stuchbury, G., Holtum, J., Burnell, J. and Muench, G. (2009), 'The thiamine analogue and advanced glycation endproducts crosslink breaker ALT-711 does not interfere with transketolase activity', Open Longevity Science, 5.
• Hegele, J., Muench, G. and Pischetsrieder, M. (2009), 'Identification of hydrogen peroxide as a major cytotoxic component in Maillard reaction mixtures and coffee', Mol Nutr Food Res, 10.
• Fuller, S., Steele, M. and Muench, G. (2009), 'Activated astrocytes - a therapeutic target in Alzheimer's disease?', Expert Rev Neurotherapeutics, 10.
• Bigl, K., Gaunitz, F., Schmitt, A., Rothemund, S., Schliebs, R., Muench, G. and Arendt, T. (2008), 'Cytotoxicity of advanced glycation endproducts in human micro- and astroglial cell lines depends on the degree of protein glycation', Journal of Neural Transmission, 12.
• Maczurek, A., Hager, K., Kenklies, M., Sharman, M., Martins, R., Engel, J., Carlson, D. and Muench, G. (2008), 'Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease', Advanced Drug Delivery Reviews, 8.
• Shanmugam, K., Holmquist, L., Steele, M., Stuchbury, G., Berbaum, K., Muench, G. and + 6 Externals, . (2008), 'Plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages', Mol Nutr Food Res, 12.
• Berbaum, K., Shanmugam, K., Stuchbury, G., Wiede, F., Korner, H. and Muench, G. (2008), 'Induction of novel cytokines and chemokines by advanced glycation endproducts determined with a cytometric bead array', Cytokine, 6.
• Maczurek, A., Shanmugam, K. and Muench, G. (2008), 'Inflammation and the redox-sensitive AGE-RAGE pathway as a therapeutic target in Alzheimer's disease', Annals of the New York Academy of Sciences, 5.
• Kuhla, B., Haase, C., Flach, K., Luth, H., Arendt, T. and Muench, G. (2007), 'Effect of pseudophosphorylation and cross-linking by lipid peroxidation and advanced glycation end product precursors on tau aggregation and filament formation', Journal of Biological Chemistry, 8.
• Holmquist, L., Stuchbury, G., Berbaum, K., Muscat, S., Young, S., Hager, K., Engel, J. and Muench, G. (2007), 'Lipoic acid as a novel treatment for Alzheimer's disease and related dementias', Pharmacology and Therapeutics, 11.
• de Arriba, S., Stuchbury, G., Yarin, J., Burnell, J., Loske, C. and Muench, G. (2007), 'Methylglyoxal impairs glucose metabolism and leads to energy depletion in neuronal cells-protection by carbonyl scavengers', Neurobiology of Aging, 7.
• Kuhla, B., Boeck, K., Schmidt, A., Ogunlade, V., Arendt, T., Muench, G. and Luth, H. (2007), 'Age- and stage-dependent glyoxalase I expression and its activity in normal and Alzheimer's disease brains', Neurobiology of Aging, 13.
• Schmidt, A., Kuhla, B., Bigl, K., Muench, G. and Arendt, T. (2007), 'Cell cycle related signaling in neuro2a cells proceeds via the receptor for advanced glycation end products', Journal of Neural Transmission, 12.
• Holmquist, L., Stuchbury, G., Steele, M. and Muench, G. (2007), 'Hydrogen peroxide is a true first messenger.', Journal of neural transmission. Supplementum, 3.
• Hager, K., Kenklies, M., Wenke, M., Fleischer, G., Engel, J. and Muench, G. (2007), '?-lipoic acid as a new treatment option for Alzheimer's disease- a follow-up analysis', Journal of neural transmission. Supplementum, 5.
• Steele, M., Stuchbury, G. and Muench, G. (2007), 'The molecular basis of the prevention of Alzheimer's disease through healthy nutrition', Experimental Gerontology, 9.
• Bigl, K., Schmitt, A., Meiners, I., Muench, G. and Arendt, T. (2007), 'Comparison of results of the CellTiter Blue, the tetrazolium (3-[4,5-dimethylthioazol-2-yl]-2,5-diphenyl tetrazolium bromide), and the lactate dehydrogenase assay applied in brain cells after exposure to advanced glycation endproducts', Toxicology in Vitro, 10.
• Muscat, S., Pelka, J., Hegele, J., Weigle, B., Muench, G. and Pischetsrieder, M. (2007), 'Coffee and Maillard products activate NF-I?B in macrophages via H2O2 production', Molecular Nutrition and Food Research, 11.
• Kuhla, B., Boeck, K., Luth, H., Schmidt, A., Weigle, B., Schmitz, M., Ogunlade, V., Muench, G. and Arendt, T. (2006), 'Age-dependent changes of glyoxalase I expression in human brain', Neurobiology of Aging, 8.
• Kuhla, B., Luth, H., Haferburg, D., Weick, M., Reichenbach, A., Arendt, T. and Muench, G. (2006), 'Pathological effects of glyoxalase I inhibition in SH-SY5Y neuroblastoma cells', Journal of Neuroscience Research, 10.
• De Arriba, G., Muench, G., Nieber, K., Allgaier, C., Krugel, U., Regenthal, R., Vissiennon, Z., Verdaguer, E., Lewerenz, A., Garcia-Jorda, E., Pallas, M. and Camins, A. (2006), 'Carbonyl stress and NMDA receptor activation contribute to methylglyoxal neurotoxicity', Free Radical Biology and Medicine, 12.
• Langer, A., Poon, H., Muench, G., Lynn, B., Arendt, T. and Butterfield, D. (2006), 'Identification of AGE-modified proteins in SH-SY5Y and OLN-93 Cells', Neurotoxicity Research, 14.
• Huber, A., Stuchbury, G., Burkle, A., Burnell, J. and Muench, G. (2006), 'Neuroprotective therapies for Alzheimer's disease', Current Pharmaceutical Design, 13.
• Schmitt, A., Schmitt, J., Muench, G. and Gasic-Milencovic, J. (2005), 'Characterization of advanced glycation end products for biochemical studies: Side chain modifications and fluorescence characteristics', Analytical Biochemistry, 15.
• Ahmed, N., Ahmed, U., Thornalley, P., Hager, K., Fleischer, G. and Muench, G. (2005), 'Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment', Journal of Neurochemistry, 9.
• Richter, T., Muench, G., Luth, H., Arendt, T., Kientsch-Engel, R., Stahl, P., Fengler, D. and Kuhla, B. (2005), 'Immunochemical crossreactivity of antibodies specific for "advanced glycation endproducts" with "advanced lipoxidation endproducts"', Neurobiology of Aging, 10.
• Stuchbury, G. and Muench, G. (2005), 'Alzheimer's associated inflammation, potential drug targets and future therapies', Journal of Neural Transmission, 25.
• Webster, J., Wilke, M., Stahl, P., Kientsch-Engel, R. and Muench, G. (2005), 'Maillard reaction products in food as pro-inflammatory and pro-arteriosclerotic factors of degenerative diseases [Maillardprodukte aus lebensmitteln als pro-entz??ndliche und pro-arteriosklerotische faktoren bei degenerativen erkrankungen]', Zeitschrift fur Gerontologie und Geriatrie, 7.
• Webster, J., Urban, C., Berbaum, K., Loske, C., Alpar, A., Gartner, U., De Arriba, S., Arendt, T. and Muench, G. (2005), 'The carbonyl scavengers aminoguanidine and tenilsetam protect against the neurotoxic effects of methylglyoxal', Neurotoxicity Research, 7.
• Luth, H., Ogunlade, V., Kuhla, B., Kientsch-Engel, R., Stahl, P., Webster, J., Arendt, T. and Muench, G. (2005), 'Age- and stage-dependent accumulation of advanced glycation end products in intracellular deposits in normal and Alzheimer's disease brains', Cerebral Cortex, 10.
• Wihler, C., Baynes, J., Huber, J., Schafer, S., Schmid, K., Deemer, E., Muench, G., Bleich, M., Busch, A., Dingermann, T. and Somoza, V. (2005), 'Renal accumulation and clearance of advanced glycation end-products in type 2 diabetic nephropathy: Effect of angiotensin-converting enzyme and vasopeptidase inhibition', Diabetologia, 9.
• Schmitt, A., Meiners, I., Schmitt, J., Noller, J., Ihling, C., Muench, G., Sinz, A. and Nieber, K. (2005), 'Two analytical methods to study the interaction of AGEs with cell surface proteins', Journal of Biochemical and Biophysical Methods, 16.
• Chen, F., Wollmer, M., Hoerndi, F., Muench, G., Kuhla, B., Rogaev, E., Tsolaki, M., Papassotiropoulos, A. and Gotz, J. (2004), 'Role for glyoxalase I in Alzheimer's disease', Proceedings of the National Academy of Sciences of the United States of America, 6.
• Robinson, S., Bishop, G., Lee, H. and Muench, G. (2004), 'Lessons from the AN 1792 Alzheimer vaccine: Lest we forget', Neurobiology of Aging, 7.
• Meiners, I., Hauschildt, S., Nieber, K. and Muench, G. (2004), 'Pentoxyphylline and propentophylline are inhibitors of TNF-I? release in monocytes activated by advanced glycation endproducts', Journal of Neural Transmission, 7.
• Kuhla, B., Loske, C., De Arriba, S., Schninzel, R., Huber, J. and Muench, G. (2004), 'Differential effects of "Advanced glycation endproducts" and I?-amyloid peptide on glucose utilization and ATP levels in the neuronal cell line SH-SY5Y', Journal of Neural Transmission, 13.
• Muench, G., Gasic-Milenkovic, J., Dukic-Stefanovic, S., Kuhla, B., Heinrich, K., Reiderer, P., Huttunen, H., Founds, H. and Sajithlal, G. (2003), 'Microglial activation induces cell death, inhibits neurite outgrowth and causes neurite retraction of differentiated neuroblastoma cells', Experimental Brain Research, 8.
• Dukic-Stefanovic, S., Gasic-Milenkovic, J., Deuther-Conrad, W. and Muench, G. (2003), 'Signal transduction pathways in mouse microglia N-11 cells activated by advanced glycation endproducts (AGEs)', Journal of Neurochemistry, 12.
• Muench, G., Apelt, J., Kientsch-Engel, R., Stahl, P., Luth, P. and Schliebs, R. (2003), 'Advanced glycation endproducts and pro-inflammatory cytokines in transgenic Tg2576 mice with amyloid plaque pathology', Journal of Neurochemistry, 7.
• Galler, A., Muller, G., Schinzel, R., Kratzsch, J., Kiess, W. and Muench, G. (2003), 'Impact of metabolic control and serum lipids on the concentration of advanced glycation end products in the serum of children and adolescents with type 1 diabetes, as determined by fluorescence spectroscopy and NI?-(carboxymethyl) lysine ELISA', Diabetes Care, 7.
• Robinson, S., Bishop, G. and Muench, G. (2003), 'Alzheimer vaccine: Amyloid-I? on trial', BioEssays, 6.
• Gasic-Milenkovic, J., Loske, C. and Muench, G. (2003), 'Advanced glycation endproducts cause lipid peroxidation in the human neuronal cell line SH-SY5Y', Journal of Alzheimer's Disease, 6.
• De Arriba, S., Loske, C., Meiners, I., Fleischer, G., Lobisch, M., Wessel, K., Tritschler, H., Schinzel, R. and Muench, G. (2003), 'Advanced Glycation Endproducts Induce Changes in Glucose Consumption, Lactate Production, and ATP Levels in SH-SY5Y Neuroblastoma Cells by a Redox-Sensitive Mechanism', Journal of Cerebral Blood Flow and Metabolism, 7.
• Gasic-Milenkovic, J., Dukic-Stefanovic, S., Deuther-Conrad, W., Gartner, U. and Muench, G. (2003), 'I?-Amyloid peptide potentiates inflammatory responses induced by lipopolysaccharide, interferon -I? and 'advanced glycation endproducts' in a murine microglia cell line', European Journal of Neuroscience, 9.
• Luth, H., Muench, G. and Arendt, T. (2002), 'Aberrant expression of NOS isoforms in Alzheimer's disease is structurally related to nitrotyrosine formation', Brain Research, 9.
• Sajithlal, G., Huttunen, H., Rauvala, H. and Muench, G. (2002), 'Receptor for advanced glycation end products plays a more important role in cellular survival than in neurite outgrowth during retinoic acid-induced differentiation of neuroblastoma cells', Journal of Biological Chemistry, 10.
• Dukic-Stefanovic, S., Schicktanz, D., Wong, A., Palm, D., Riederer, P., Niwa, T., Schinzel, R. and Muench, G. (2002), 'Characterization of antibody affinities using an AGE-modified dipeptide spot library', Journal of Immunological Methods, 8.
• Muench, G. and Robinson, S. (2002), 'Potential neurotoxic inflammatory responses to AI? vaccination in humans', Journal of Neural Transmission, 7.
• Muench, G. and Robinson, S. (2002), 'Alzheimer's vaccine: A cure as dangerous as the disease?', Journal of Neural Transmission, 3.
• Wong, A., Luth, H., Deuther-Conrad, W., Dukic-Stefanovic, S., Gasic-Milenkovic, J., Arendt, T. and Muench, G. (2001), 'Advanced glycation endproducts co-localize with inducible nitric oxide synthase in Alzheimer's disease', Brain Research, 9.
• Hager, K., Marahrens, A., Kenklies, M., Riederer, P. and Muench, G. (2001), 'Alpha-lipoic acid as a new treatment option for Azheimer type dementia', Archives of Gerontology and Geriatrics, 8.
• Deuther-Conrad, W., Loske, C., Schinzel, R., Dringen, R., Riederer, P. and Muench, G. (2001), 'Advanced glycation endproducts change glutathione redox status in SH-SY5Y human neuroblastoma cells by a hydrogen peroxide dependent mechanism', Neuroscience Letters, 4.
• Gasci-Milenkovic, J., Loske, C., Deuther-Conrad, W. and Muench, G. (2001), 'Protein "AGEing" - Cytotoxicity of a glycated protein increases with its degree of AGE-modification', Zeitschrift fur Gerontologie und Geriatrie, 4.
• Dukic-Stefanovic, S., Schinzel, R., Riederer, P. and Muench, G. (2001), 'AGES in the brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs?', Biogerontology, 16.
• Wong, A., Dukic-Stefanovic, S., Gasic-Milenkovic, J., Schinzel, R., Wiesinger, H., Riederer, P. and Muench, G. (2001), 'Anti-inflammatory antioxidants attenuate the expression of inducible nitric oxide synthase mediated by advanced glycation endproducts in murine microglia', European Journal of Neuroscience, 7.