Professor Gerald Muench

Professor Gerald Muench

Director, International Student Academic Support,
School of Medicine

PROFESSOR PHARMACOLOGY,
School of Medicine

Biography

Gerald Muench started work at the University of Würzburg, Germany in 1995 and was then appointed Lecturer in the Department of Child and Adolescent Psychiatry in 1999. In 2000, he joined the Interdisciplinary Center for Clinical Research at the University of Leipzig. He left in 2004 to take up a position as Senior Lecturer at James Cook University in Townsville.

In May 2008 Gerald was appointed as Associate Professor of Pharmacology in the School of Medicine at the University of Western Sydney, and he was promoted to Professor with effect from 1 January 2012.

His major project focus is on Alzheimer's disease with a special emphasis on carbonyl stress in age-related and neurodegenerative processes, and also looking at brain inflammation as a major progression factor in Alzheimer's disease, now widely accepted.

He is also looking to discover and identify novel anti-inflammatory and neuroprotective compounds from marine macroorganisms and tropical rainforest plants, a project started through James Cook University's "Enhancing life in the tropics".

Gerald has served on the editorial boards of six international scientific journals and has been a consultant with Aventis, Roche Diagnostics, Merz, ASTA Medica/Degussa and Blackmores.

His teaching philosophy is to show students how much fun the learning experience can be and define precisely what they need to know and understand when the standards are high.

Awards and Recognition:

Rene Schubert Prize of the "German Society for Aging Research" (Dt. Gesellschaft für Alternsforschung), 2003

Best Biomedical Project in the Business Plan Competition of the Bavarian State Government & McKinsey for Northern Bavaria, 1999

Senior Scientist Visiting Fellowship (Australian Academy of Science / DFG), Host: Prof. Robin Holliday, Division of Biomolecular Engineering, CSIRO; North Ryde, NSW, 1998

Prize for Brain Research in Gerontology, Universität Witten-Herdecke, Germany, 1997

University Prize of the "Jubilumsstiftung der Universität", University of Würzburg, Germany, 1996

Stifterverband der dt. Wissenschaft (German Association of Private Foundations) Research Associate Fellowship, 1995

DFG (German Research Council) Postdoctoral Fellowship (Garvan Institute, Sydney: Host: Professor J. Shine), 1993

University prize for the best PhD thesis of the faculty, 1991

This information has been contributed by Professor Muench.

Qualifications

  • PhD Julius Maximilian University of Bavaria, Wurzburg
  • MSc(Chem) Julius Maximilian University of Bavaria, Wurzburg

Interests

  • Biochemistry
  • Biotechnology
  • Cell Biology
  • Molecular Biology
  • Molecular Genetics
  • Pharmacology

UWS Organisational Unit (School / Division)

  • School of Medicine
  • School of Medicine

Contact

Email: G.Muench@uws.edu.au
Phone: (02) 4620 3814
Mobile:
Location: 30.2.17
Campbelltown
Website:

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Publications

Chapters in Books

  • Maczurek, A., Ooi, L., Patel, M. and Muench, G. (2013), 'Lipoic acid as an anti-inflammatory and neuroprotective tretment for Alzheimer's disease ', Advances in Natural Medicines, Nutraceuticals and Neurocognition, CRC press 9781439893609.
  • Gunawardena, D., Govindaraghavan, S. and Muench, G. (2013), 'Anti-inflammatory properties of cinnamon polyphenols and their monomeric precursors ', Polyphenols in Human Health and Disease Volume 1, Academic Press 9780123984715.

Journal Articles

  • Gunawardena, D., Muench, G., Bennett, L., Shanmugam, K., King, K., Williams, R., Zabaras, D., Head, R., Ooi, L. and Gyengesi, E. (2014), 'Anti-inflammatory effects of five commercially available mushroom species determined in lipopolysaccharide and interferon-gamma activated murine macrophages', Food Chemistry, vol 148 , pp 92 - 96.
  • Gunawardena, D., Shanmugam, K., Low, M., Bennett, L., Govindaraghavan, S., Head, R., Ooi, L. and Muench, G. (2014), 'Determination of anti-inflammatory activities of standardised preparations of plant- and mushroom-based foods', European Journal of Nutrition, vol 53, no 1 , pp 335 - 343.
  • Steele, M., Fuller, S., Maczurek, A., Kersaitis, C., Ooi, L. and Muench, G. (2013), 'Chronic inflammation alters production and release of glutathione and related thiols in human U373 astroglial cells', Cell and Molecular Neurobiology, vol 33, no 1 , pp 19 - 30.
  • Srikanth, V., Muench, G., Westcott, B., Forbes, J., Phan, T., Beare, R., Venn, A., Pearson, S., Greenaway, T. and Parameswaran, V. (2013), 'Methylglyoxal, cognitive function and cerebral atrophy in older people', Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol 68, no 1 , pp 68 - 73.
  • Steele, M., Truong, J., Govindaraghavan, S., Ooi, L., Sucher, N. and Muench, G. (2013), 'Cytoprotective properties of traditional Chinese medicinal herbal extracts in hydrogen peroxide challenged human U373 astroglia cells', Neurochemistry International, vol 62, no 5 , pp 522 - 529.
  • Ooi, L., Sidhu, K., Poljak, A., Sutherland, G., O'Connor, M., Sachdev, P. and Muench, G. (2013), 'Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer's disease', Journal of Neural Transmission, vol 120, no 1 , pp 103 - 111.
  • Rahman, S., Basilakis, J., Rahmadi, A., Lujic, S., Musgrave, I., Jorm, L., Hay, P. and Muench, G. (2013), 'Use of serotonergic antidepressants and St John's wort in older Australians : a population-based cohort study', Australasian Psychiatry, vol 21, no 3 , pp 262 - 266.
  • Maczurek, A., Wild, R., Laurenti, D., Steele, M., Ooi, L. and Muench, G. (2013), 'Generation of hydrogen peroxide-resistant murine neuroblastoma cells : a target discovery platform for novel neuroprotective genes', Journal of Neural Transmission, vol 120, no 8 , pp 1171 - 1178.
  • Sauer, T., Raithel, M., Kressel, J., Muench, G. and Pischetsrieder, M. (2013), 'Activation of the transcription factor Nrf2 in macrophages, Caco-2 cells and intact human gut tissue by Maillard reaction products and coffee', Amino Acids, vol 44, no 6 , pp 1427 - 1439.
  • Jayasena, T., Poljak, A., Smythe, G., Braidy, N., Muench, G. and Sachdev, P. (2013), 'The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease', Ageing Research Reviews, vol 12, no 4 , pp 867 - 883.
  • Bennett, L., Zabaras, D., Bird, M., Kersaitis, C., Macaulay, S., Muench, G., Niedermayer, G., Nigro, J., Payne, M., Sheean, P. and Vallotton, P. (2013), 'Vitamin D2-Enriched Button Mushroom (Agaricus bisporus) Improves Memory in Both Wild Type and APPswe/PS1dE9 Transgenic Mice', PLoS ONE, vol 8, no 10 .
  • Steele, M., Fuller, S., Patel, M., Kersaitis, C., Ooi, L. and Muench, G. (2013), 'Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells', Redox Biology, vol 1, no 1 , pp 441 - 445.
  • Nguyen, N., Ooi, L., Piller, S. and Muench, G. (2013), 'Proenergetic effects of resveratrol in the murine neuronal cell line Neuro2a', Molecular Nutrition and Food Research, vol 57, no 11 , pp 1901 - 1907.
  • Wild, R., Ooi, L., Srikanth, V. and Muench, G. (2012), 'A quick, convenient and economical method for the reliable determination of methylglyoxal in millimolar concentrations : the N-acetyl-L-cysteine assay', Analytical and Bioanalytical Chemistry, vol 403, no 9 , pp 2577 - 2581.
  • Steele, M., Ooi, L. and Muench, G. (2012), 'Development of a high-performance liquid chromatography method for the simultaneous quantitation of glutathione and related thiols', Analytical Biochemistry, vol 429, no 1 , pp 45 - 52.
  • Ravipati, A., Wu, M., Satyanarayanan, M., Vysetti, B., Zhang, L., Koyyalamudi, S., Jeong, S., Reddy, N., Bartlett, J., Smith, P., Shanmugam, K. and Muench, G. (2012), 'Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content', BMC Complementary and Alternative Medicine, vol 12 , pp 1 - 14.
  • Muench, G., Westcott, B., Menini, T. and Gugliucci, A. (2012), 'Advanced glycation endproducts and their pathogenic roles in neurological disorders', Amino Acids, vol 42, no 4 , pp 1221 - 1236.
  • Zhang, L., Wu, M., Ravipati, A., Koyyalamudi, S., Jeong, S., Reddy, N., Smith, P., Bartlett, J., Shanmugam, K. and Muench, G. (2011), 'Antioxidant and anti-inflammatory activities of selected medicinal plants containing phenolic and flavonoid compounds', Journal of Agricultural and Food Chemistry, vol 59, no 23 , pp 12361 - 12367.
  • Sauer, T., Raithel, M., Kressel, J., Muscat, S., Muench, G. and Pischetsrieder, M. (2011), 'Nuclear translocation of NF-kB in intact human gut tissue upon stimulation with coffee and roasting products', Food and Function, vol 2, no 9 , pp 529 - 540.
  • Rahmadi, A., Steiner, N. and Muench, G. (2011), 'Advanced glycation endproducts as gerontotoxins and biomarkers for carbonyl-based degenerative processes in Alzheimer's disease', Clinical Chemistry and Laboratory Medicine, vol 49, no 3 , pp 385 - 391.
  • Krautwald, M., Leech, D., Horne, S., Steele, M., Forbes, J., Rahmadi, A., Griffith, R. and Muench, G. (2011), 'The advanced glycation end product-lowering agent ALT-711 Is a Low-Affinity inhibitor of thiamine Diphosphokinase', Rejuvenation Research, vol 14, no 4 , pp 383 - 391.
  • Srikanth, V., Maczurek, A., Phan, T., Steele, M., Westcott, B., Juskiw, D. and Muench, G. (2011), 'Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease', Neurolbiol Aging, vol 32, no 5 , pp 763 - 777.
  • Vallotton, P., Sun, C., Lovell, D., Savelsbergh, M., Payne, M. and Muench, G. (2011), 'Identifying weak linear features with the "coalescing shortest path image transform"', Microscopy and Microanalysis, vol 17, no 6 , pp 911 - 914.
  • Stutchbury, G. and Muench, G. (2010), 'Optimizing the generation of stable neuronal cell lines via pre-transfection restriction enzyme digestion of plasmid DNA', Cytotechnology, vol 62, no 3 , pp 189 - 194.
  • Krautwald, M. and Muench, G. (2010), 'Advanced glycation end products as biomarkers and gerontotoxins - A basisto explore methylglyoxal-lowering agents for Alzheimer's disease?', Experimental Gerontology, vol 45, no 10 , pp 744 - 751.
  • Hansen, E., Korner, H., Muench, G., Krautwald, M., Maczurek, A., Stutchbury, G., Fromm, P., Steele, M., Schulz, O., Garcia, O. and Castillo, J. (2010), 'A versatile high throughput screening system for the simultaneous identification of anti-inflammatory and neuroprotective compounds', Journal of Alzheimer's Disease, vol 19, no 2 , pp 451 - 464.
  • Chandler, D., Muench, G., Woldu, A., Rahmadi, A., Shanmugam, K., Steiner, N., Wright, E., Benavente-Garcia, O., Schulz, O. and Castillo, J. (2010), 'Effects of plant-derived polyphenols on TNF-alpha and nitric oxide production induced by advanced glycation endproducts', Molecular Nutrition and Food Research, vol 54, no 2 , pp 141 - 150.
  • Fuller, S., Steele, M. and Muench, G. (2010), 'Activated astroglia during chronic inflammation in Alzheimer's disease - do they neglect their neurosupportive roles?', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol 690, no 1-2 , pp 40 - 49.
  • Muscat, S., Pischetsrieder, M., Maczurek, A., Rothemund, S. and Muench, G. (2009), 'Cytotoxicity of Maillard reaction products determined with a peptide spot library', Mol Nutr Food Res, vol 53, no 8 , pp 1019 - 1029.
  • Krautwald, M., Maxwell, P., Stuchbury, G., Holtum, J., Burnell, J. and Muench, G. (2009), 'The thiamine analogue and advanced glycation endproducts crosslink breaker ALT-711 does not interfere with transketolase activity', Open Longevity Science, vol 3, no 5 , pp 11 - 15.
  • Hegele, J., Muench, G. and Pischetsrieder, M. (2009), 'Identification of hydrogen peroxide as a major cytotoxic component in Maillard reaction mixtures and coffee', Mol Nutr Food Res, vol 53, no 6 , pp 760 - 769.
  • Fuller, S., Steele, M. and Muench, G. (2009), 'Activated astrocytes - a therapeutic target in Alzheimer's disease?', Expert Rev Neurotherapeutics, vol 9, no 11 , pp 1585 - 1594.
  • Bigl, K., Gaunitz, F., Schmitt, A., Rothemund, S., Schliebs, R., Muench, G. and Arendt, T. (2008), 'Cytotoxicity of advanced glycation endproducts in human micro- and astroglial cell lines depends on the degree of protein glycation', Journal of Neural Transmission, vol 115, no 11 , pp 1545 - 1556.
  • Maczurek, A., Hager, K., Kenklies, M., Sharman, M., Martins, R., Engel, J., Carlson, D. and Muench, G. (2008), 'Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease', Advanced Drug Delivery Reviews, vol 60, no 13-14 , pp 1463 - 1470.
  • Shanmugam, K., Rivas, V., Dobson, G., Muench, G., Holmquist, L., Steele, M., Stuchbury, G., Berbaum, K., Schulz, O., Garcia, O., Castillo, J. and Burnell, J. (2008), 'Plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages', Mol Nutr Food Res, vol 52, no 4 , pp 427 - 438.
  • Shanmugam, K., Rivas, V., Dobson, G., Muench, G., Holmquist, L., Steele, M., Stuchbury, G., Berbaum, K., Schulz, O., Garcia, O., Castillo, J. and Burnell, J. (2008), 'Plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages', Mol Nutr Food Res, vol 52, no 4 , pp 427 - 438.
  • Berbaum, K., Shanmugam, K., Stuchbury, G., Wiede, F., Korner, H. and Muench, G. (2008), 'Induction of novel cytokines and chemokines by advanced glycation endproducts determined with a cytometric bead array', Cytokine, vol 41, no 3 , pp 198 - 203.
  • Maczurek, A., Shanmugam, K. and Muench, G. (2008), 'Inflammation and the redox-sensitive AGE-RAGE pathway as a therapeutic target in Alzheimer's disease', Annals of the New York Academy of Sciences, vol 1126, no 0 , pp 147 - 151.
  • Kuhla, B., Haase, C., Flach, K., Luth, H., Arendt, T. and Muench, G. (2007), 'Effect of pseudophosphorylation and cross-linking by lipid peroxidation and advanced glycation end product precursors on tau aggregation and filament formation', Journal of Biological Chemistry, vol 282, no 10 , pp 6984 - 6991.
  • Holmquist, L., Stuchbury, G., Berbaum, K., Muscat, S., Young, S., Hager, K., Engel, J. and Muench, G. (2007), 'Lipoic acid as a novel treatment for Alzheimer's disease and related dementias', Pharmacology and Therapeutics, vol 113, no 1 , pp 154 - 164.
  • de Arriba, S., Stuchbury, G., Yarin, J., Burnell, J., Loske, C. and Muench, G. (2007), 'Methylglyoxal impairs glucose metabolism and leads to energy depletion in neuronal cells-protection by carbonyl scavengers', Neurobiology of Aging, vol 28, no 7 , pp 1044 - 1050.
  • Kuhla, B., Boeck, K., Schmidt, A., Ogunlade, V., Arendt, T., Muench, G. and Luth, H. (2007), 'Age- and stage-dependent glyoxalase I expression and its activity in normal and Alzheimer's disease brains', Neurobiology of Aging, vol 28, no 1 , pp 29 - 41.
  • Schmidt, A., Kuhla, B., Bigl, K., Muench, G. and Arendt, T. (2007), 'Cell cycle related signaling in neuro2a cells proceeds via the receptor for advanced glycation end products', Journal of Neural Transmission, vol 114, no 11 , pp 1413 - 1424.
  • Holmquist, L., Stuchbury, G., Steele, M. and Muench, G. (2007), 'Hydrogen peroxide is a true first messenger.', Journal of neural transmission. Supplementum, , no 72 , pp 39 - 41.
  • Hager, K., Kenklies, M., Wenke, M., Fleischer, G., Engel, J. and Muench, G. (2007), '?-lipoic acid as a new treatment option for Alzheimer's disease- a follow-up analysis', Journal of neural transmission. Supplementum, vol 72 , pp 189 - 193.
  • Steele, M., Stuchbury, G. and Muench, G. (2007), 'The molecular basis of the prevention of Alzheimer's disease through healthy nutrition', Experimental Gerontology, vol 42, no 40575 , pp 28 - 36.
  • Bigl, K., Schmitt, A., Meiners, I., Muench, G. and Arendt, T. (2007), 'Comparison of results of the CellTiter Blue, the tetrazolium (3-[4,5-dimethylthioazol-2-yl]-2,5-diphenyl tetrazolium bromide), and the lactate dehydrogenase assay applied in brain cells after exposure to advanced glycation endproducts', Toxicology in Vitro, vol 21, no 5 , pp 962 - 971.
  • Muscat, S., Pelka, J., Hegele, J., Weigle, B., Muench, G. and Pischetsrieder, M. (2007), 'Coffee and Maillard products activate NF-I?B in macrophages via H2O2 production', Molecular Nutrition and Food Research, vol 51, no 5 , pp 525 - 535.
  • Kuhla, B., Boeck, K., Luth, H., Schmidt, A., Weigle, B., Schmitz, M., Ogunlade, V., Muench, G. and Arendt, T. (2006), 'Age-dependent changes of glyoxalase I expression in human brain', Neurobiology of Aging, vol 27, no 6 , pp 815 - 822.
  • Kuhla, B., Luth, H., Haferburg, D., Weick, M., Reichenbach, A., Arendt, T. and Muench, G. (2006), 'Pathological effects of glyoxalase I inhibition in SH-SY5Y neuroblastoma cells', Journal of Neuroscience Research, vol 83, no 8 , pp 1591 - 1600.
  • De Arriba, G., Muench, G., Nieber, K., Allgaier, C., Krugel, U., Regenthal, R., Vissiennon, Z., Verdaguer, E., Lewerenz, A., Garcia-Jorda, E., Pallas, M. and Camins, A. (2006), 'Carbonyl stress and NMDA receptor activation contribute to methylglyoxal neurotoxicity', Free Radical Biology and Medicine, vol 40, no 5 , pp 779 - 790.
  • Langer, A., Poon, H., Muench, G., Lynn, B., Arendt, T. and Butterfield, D. (2006), 'Identification of AGE-modified proteins in SH-SY5Y and OLN-93 Cells', Neurotoxicity Research, vol 9, no 4 , pp 255 - 268.
  • Huber, A., Stuchbury, G., Burkle, A., Burnell, J. and Muench, G. (2006), 'Neuroprotective therapies for Alzheimer's disease', Current Pharmaceutical Design, vol 12, no 6 , pp 705 - 717.
  • Schmitt, A., Schmitt, J., Muench, G. and Gasic-Milencovic, J. (2005), 'Characterization of advanced glycation end products for biochemical studies: Side chain modifications and fluorescence characteristics', Analytical Biochemistry, vol 338, no 2 , pp 201 - 215.
  • Ahmed, N., Ahmed, U., Thornalley, P., Hager, K., Fleischer, G. and Muench, G. (2005), 'Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment', Journal of Neurochemistry, vol 92, no 2 , pp 255 - 263.
  • Richter, T., Muench, G., Luth, H., Arendt, T., Kientsch-Engel, R., Stahl, P., Fengler, D. and Kuhla, B. (2005), 'Immunochemical crossreactivity of antibodies specific for "advanced glycation endproducts" with "advanced lipoxidation endproducts"', Neurobiology of Aging, vol 26, no 4 , pp 465 - 474.
  • Stuchbury, G. and Muench, G. (2005), 'Alzheimer's associated inflammation, potential drug targets and future therapies', Journal of Neural Transmission, vol 112, no 3 , pp 429 - 453.
  • Webster, J., Wilke, M., Stahl, P., Kientsch-Engel, R. and Muench, G. (2005), 'Maillard reaction products in food as pro-inflammatory and pro-arteriosclerotic factors of degenerative diseases [Maillardprodukte aus lebensmitteln als pro-entz??ndliche und pro-arteriosklerotische faktoren bei degenerativen erkrankungen]', Zeitschrift fur Gerontologie und Geriatrie, vol 38, no 5 , pp 347 - 353.
  • Webster, J., Urban, C., Berbaum, K., Loske, C., Alpar, A., Gartner, U., De Arriba, S., Arendt, T. and Muench, G. (2005), 'The carbonyl scavengers aminoguanidine and tenilsetam protect against the neurotoxic effects of methylglyoxal', Neurotoxicity Research, vol 7, no 40575 , pp 95 - 101.
  • Luth, H., Ogunlade, V., Kuhla, B., Kientsch-Engel, R., Stahl, P., Webster, J., Arendt, T. and Muench, G. (2005), 'Age- and stage-dependent accumulation of advanced glycation end products in intracellular deposits in normal and Alzheimer's disease brains', Cerebral Cortex, vol 15, no 2 , pp 211 - 220.
  • Wihler, C., Baynes, J., Huber, J., Schafer, S., Schmid, K., Deemer, E., Muench, G., Bleich, M., Busch, A., Dingermann, T. and Somoza, V. (2005), 'Renal accumulation and clearance of advanced glycation end-products in type 2 diabetic nephropathy: Effect of angiotensin-converting enzyme and vasopeptidase inhibition', Diabetologia, vol 48, no 8 , pp 1645 - 1653.
  • Schmitt, A., Meiners, I., Schmitt, J., Noller, J., Ihling, C., Muench, G., Sinz, A. and Nieber, K. (2005), 'Two analytical methods to study the interaction of AGEs with cell surface proteins', Journal of Biochemical and Biophysical Methods, vol 65, no 40604 , pp 121 - 136.
  • Chen, F., Wollmer, M., Hoerndi, F., Muench, G., Kuhla, B., Rogaev, E., Tsolaki, M., Papassotiropoulos, A. and Gotz, J. (2004), 'Role for glyoxalase I in Alzheimer's disease', Proceedings of the National Academy of Sciences of the United States of America, vol 101, no 20 , pp 7687 - 7692.
  • Robinson, S., Bishop, G., Lee, H. and Muench, G. (2004), 'Lessons from the AN 1792 Alzheimer vaccine: Lest we forget', Neurobiology of Aging, vol 25, no 5 , pp 609 - 615.
  • Meiners, I., Hauschildt, S., Nieber, K. and Muench, G. (2004), 'Pentoxyphylline and propentophylline are inhibitors of TNF-I? release in monocytes activated by advanced glycation endproducts', Journal of Neural Transmission, vol 111, no 3 , pp 441 - 447.
  • Kuhla, B., Loske, C., De Arriba, S., Schninzel, R., Huber, J. and Muench, G. (2004), 'Differential effects of "Advanced glycation endproducts" and I?-amyloid peptide on glucose utilization and ATP levels in the neuronal cell line SH-SY5Y', Journal of Neural Transmission, vol 111, no 3 , pp 427 - 439.
  • Muench, G., Gasic-Milenkovic, J., Dukic-Stefanovic, S., Kuhla, B., Heinrich, K., Reiderer, P., Huttunen, H., Founds, H. and Sajithlal, G. (2003), 'Microglial activation induces cell death, inhibits neurite outgrowth and causes neurite retraction of differentiated neuroblastoma cells', Experimental Brain Research, vol 150, no 1 , pp 1 - 8.
  • Dukic-Stefanovic, S., Gasic-Milenkovic, J., Deuther-Conrad, W. and Muench, G. (2003), 'Signal transduction pathways in mouse microglia N-11 cells activated by advanced glycation endproducts (AGEs)', Journal of Neurochemistry, vol 87, no 1 , pp 44 - 55.
  • Muench, G., Apelt, J., Kientsch-Engel, R., Stahl, P., Luth, P. and Schliebs, R. (2003), 'Advanced glycation endproducts and pro-inflammatory cytokines in transgenic Tg2576 mice with amyloid plaque pathology', Journal of Neurochemistry, vol 86, no 2 , pp 283 - 289.
  • Galler, A., Muller, G., Schinzel, R., Kratzsch, J., Kiess, W. and Muench, G. (2003), 'Impact of metabolic control and serum lipids on the concentration of advanced glycation end products in the serum of children and adolescents with type 1 diabetes, as determined by fluorescence spectroscopy and NI?-(carboxymethyl) lysine ELISA', Diabetes Care, vol 26, no 9 , pp 2609 - 2615.
  • Robinson, S., Bishop, G. and Muench, G. (2003), 'Alzheimer vaccine: Amyloid-I? on trial', BioEssays, vol 25, no 3 , pp 283 - 288.
  • Gasic-Milenkovic, J., Loske, C. and Muench, G. (2003), 'Advanced glycation endproducts cause lipid peroxidation in the human neuronal cell line SH-SY5Y', Journal of Alzheimer's Disease, vol 5, no 1 , pp 25 - 30.
  • De Arriba, S., Loske, C., Meiners, I., Fleischer, G., Lobisch, M., Wessel, K., Tritschler, H., Schinzel, R. and Muench, G. (2003), 'Advanced Glycation Endproducts Induce Changes in Glucose Consumption, Lactate Production, and ATP Levels in SH-SY5Y Neuroblastoma Cells by a Redox-Sensitive Mechanism', Journal of Cerebral Blood Flow and Metabolism, vol 23, no 11 , pp 1307 - 1313.
  • Gasic-Milenkovic, J., Dukic-Stefanovic, S., Deuther-Conrad, W., Gartner, U. and Muench, G. (2003), 'I?-Amyloid peptide potentiates inflammatory responses induced by lipopolysaccharide, interferon -I? and 'advanced glycation endproducts' in a murine microglia cell line', European Journal of Neuroscience, vol 17, no 4 , pp 813 - 821.
  • Luth, H., Muench, G. and Arendt, T. (2002), 'Aberrant expression of NOS isoforms in Alzheimer's disease is structurally related to nitrotyrosine formation', Brain Research, vol 953, no 1-Feb , pp 135 - 143.
  • Sajithlal, G., Huttunen, H., Rauvala, H. and Muench, G. (2002), 'Receptor for advanced glycation end products plays a more important role in cellular survival than in neurite outgrowth during retinoic acid-induced differentiation of neuroblastoma cells', Journal of Biological Chemistry, vol 277, no 9 , pp 6888 - 6897.
  • Dukic-Stefanovic, S., Schicktanz, D., Wong, A., Palm, D., Riederer, P., Niwa, T., Schinzel, R. and Muench, G. (2002), 'Characterization of antibody affinities using an AGE-modified dipeptide spot library', Journal of Immunological Methods, vol 266, no 1-Feb , pp 45 - 52.
  • Muench, G. and Robinson, S. (2002), 'Potential neurotoxic inflammatory responses to AI? vaccination in humans', Journal of Neural Transmission, vol 109, no 7-Aug , pp 1081 - 1087.
  • Muench, G. and Robinson, S. (2002), 'Alzheimer's vaccine: A cure as dangerous as the disease?', Journal of Neural Transmission, vol 109, no 4 , pp 537 - 539.
  • Wong, A., Luth, H., Deuther-Conrad, W., Dukic-Stefanovic, S., Gasic-Milenkovic, J., Arendt, T. and Muench, G. (2001), 'Advanced glycation endproducts co-localize with inducible nitric oxide synthase in Alzheimer's disease', Brain Research, vol 920, no 1-Feb , pp 32 - 40.
  • Hager, K., Marahrens, A., Kenklies, M., Riederer, P. and Muench, G. (2001), 'Alpha-lipoic acid as a new treatment option for Azheimer type dementia', Archives of Gerontology and Geriatrics, vol 32, no 3 , pp 275 - 282.
  • Deuther-Conrad, W., Loske, C., Schinzel, R., Dringen, R., Riederer, P. and Muench, G. (2001), 'Advanced glycation endproducts change glutathione redox status in SH-SY5Y human neuroblastoma cells by a hydrogen peroxide dependent mechanism', Neuroscience Letters, vol 312, no 1 , pp 29 - 32.
  • Gasci-Milenkovic, J., Loske, C., Deuther-Conrad, W. and Muench, G. (2001), 'Protein "AGEing" - Cytotoxicity of a glycated protein increases with its degree of AGE-modification', Zeitschrift fur Gerontologie und Geriatrie, vol 34, no 6 , pp 457 - 460.
  • Dukic-Stefanovic, S., Schinzel, R., Riederer, P. and Muench, G. (2001), 'AGES in the brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs?', Biogerontology, vol 2, no 1 , pp 19 - 34.
  • Wong, A., Dukic-Stefanovic, S., Gasic-Milenkovic, J., Schinzel, R., Wiesinger, H., Riederer, P. and Muench, G. (2001), 'Anti-inflammatory antioxidants attenuate the expression of inducible nitric oxide synthase mediated by advanced glycation endproducts in murine microglia', European Journal of Neuroscience, vol 14, no 12 , pp 1961 - 1967.

Conference Papers

  • Payne, M., Muench, G. and Vallotton, P. (2013), 'A new GUI based toolbox to compare particle tracking approaches', International Symposium on Comnputational Models for Life Sciences, Sydney, N.S.W..
  • Muench, G., Berbaum, K., Urban, C. and Schinzel, R. (2005), 'Proteins of Thermus thermophilus are resistant to glycation-induced protein precipitation: An evolutionary adaptation to life at extreme temperatures?', Annals of the New York Academy of Sciences, .
  • Ahmed, N., Ahmed, U., Hager, K., Fleischer, G. and Muench, G. (2005), 'Protein glycation marker residues and free adducts of cerebrospinal fluid in Alzheimer's disease and a link to cognitive impairment', Annals of the New York Academy of Sciences, .
  • Kuhla, B., Luth, H., Haferburg, D., Boeck, K., Arendt, T. and Muench, G. (2005), 'Methylglyoxal, glyoxal, and their detoxification in Alzheimer's disease', Annals of the New York Academy of Sciences, .
  • Muench, G., Kuhla, B., Luth, H., Arendt, T. and Robinson, S. (2003), 'Anti-AGEing defences against Alzheimer's disease', Biochemical Society Transactions, .
  • Muench, G., Gasic-Milenkovic, J. and Arendt, T. (2003), 'Effect of advanced glycation endproducts on cell cycle and their relevance for Alzheimer's disease', Journal of Neural Transmission, Supplement, .
  • Muench, G., Deuther-Conrad, W. and Gasic-Milenkovic, J. (2002), 'Glycoxidative stress creates a vicious cycle of neurodegeneration in Alzheimer's disease - A target for neuroprotective treatment strategies?', Journal of Neural Transmission, Supplement, .

Research

Current Projects

Title: Effects of chronic inflammation on the cholinergic neurodegeneration and its therapeutic prevention by using highly bioavailable curcumin, as an anti-inflammatory agent
Years: 2013-09-09 - 2014-11-09
ID: P00021743
UWS Researchers: Erika Gyengesi and Gerald Muench
Funding:
  • University of Western Sydney
Title: Identification and characterisation of new anti-inflammatory and neuroprotectant compounds and extracts from the Australian flora
Years: 2014-02-15 - 2018-02-14
ID: P00020996
UWS Researchers: Gerald Muench
Funding:
  • Ecobiotics Limited
Title: The role of central haemodynamics in Type 2 Diabetes Mellitus-related brain disease [via Monash Uni]
Years: 2014-03-28 - 2019-03-27
ID: P00021871
UWS Researchers: Gerald Muench
Funding:
  • National Health and Medical Research Council (ACRG)
Title: Effect of Carnosine on pro-inflammatory signalling and toxicity of advanced glycation endproducts
Years: 2008-04-29 - 2015-12-31
ID: P00016144
UWS Researchers: Gerald Muench
Funding:
  • Eurochem Feinchemie GmbH
Title: Type 2 Diabetes Mellitus and Cognitive Decline - a longitudinal study of effects and mechanisms [via Monash Uni]
Years: 2010-01-01 - 2014-12-31
ID: P00017003
UWS Researchers: Gerald Muench
Funding:
  • National Health and Medical Research Council (ACRG)
Title: Investigation of anti-inflammatory and neuroprotective activity of plant extracts for the treatment of Alzheimer's disease
Years: 2008-06-03 - 2015-12-31
ID: P00016216
UWS Researchers: Gerald Muench
Funding:
  • Nutrafur - Furfural Espanol
Title: Non animal cell systems for drug discovery for Alzheimer's disease: Replacing the use of murine neurons with induced pluripotent stem cells from Alzheimer's patients
Years: 2012-06-01 -
ID: P00020711
UWS Researchers: Lezanne Ooi and Gerald Muench
Funding:
  • The MAWA Trust

Previous Projects

Title: IDP Student Mobility Scholarship
Years: 2008-01-25 - 2010-12-31
ID: P0016107
UWS Researchers: Gerald Muench
Funding:
  • IDP Education Australia Ltd
Title: Identification of anti-inflammatory compounds from food and plant libraries as therapeutics for Alzheimer's Disease
Years: 2008-02-01 - 2011-12-31
ID: P0016110
UWS Researchers: Gerald Muench and Kirubakaran Shunmugam
Funding:
  • Commonwealth Scientific & Industrial Research Organisation (CSIRO) (ACRG)
Title: Establishment of a mass spectrometer facility for natural products and proteomics research and teaching at the College of Health and Science within the University of Western Sydney, Campbelltown campus
Years: 2008-09-24 - 2010-09-15
ID: P00016326
UWS Researchers: Nikolaus Sucher, Jens Coorssen, Bill Price, Gerald Muench, Andrew Shalliker, Vincent Higgins, Dennis Chang, Sabine Piller, Simon Myers, Colin Stack and Michelle Moffitt
Funding:
  • University of Western Sydney
Title: Activation of microglial cells by advanced glycation endproducts and beta-amyloid peptide via RAGE - a novel therapeutic target in Alzheimer's disease
Years: 2008-11-26 - 2012-12-31
ID: P00016623
UWS Researchers: Gerald Muench
Funding:
  • Abbott GmbH & Co. KG
Title: A study of mechanisms of cognitive decline in Type 2 diabetes mellitus [via Monash University]
Years: 2009-06-11 - 2011-12-31
ID: P00016232
UWS Researchers: Gerald Muench
Funding:
  • National Health and Medical Research Council (ACRG)
Title: Activation of glial cells by advanced glycation endproducts and beta-amyloid peptide via Rage - a novel therapeutic target in Alzheimer's disease
Years: 2008-04-29 - 2013-12-31
ID: P00016143
UWS Researchers: Gerald Muench
Funding:
  • TransTech Pharma
Title: Identification of neuroprotective genes from a hydrogen-peroxide and glutamate resistant neuronal cell line - a novel approach to discover novel drug targets for neurodegenerative diseases
Years: 2008-07-08 - 2013-04-30
ID: P00016284
UWS Researchers: Gerald Muench
Funding:
  • Merz Pharmaceuticals
Title: Cell and Protein Analysis Unit
Years: 2009-09-22 - 2010-09-21
ID: P00017371
UWS Researchers: Simon Myers, Jens Coorssen, Sabine Piller, Annemarie Hennessy, Janice Aldrich-Wright, Soon Lee and Gerald Muench
Funding:
  • University of Western Sydney
Title: International Efforts in Translational Medicine
Years: 2009-10-28 - 2010-10-27
ID: P00017596
UWS Researchers: Jens Coorssen, Annemarie Hennessy, Bradley Frankum, Gerald Muench, Joanne Lind, Simon Myers and Soon Lee
Funding:
  • University of Western Sydney
Title: The neurosupportive role of astroglia - a novel drug target in Alzheimer's disease
Years: 2009-12-04 - 2011-12-30
ID: P00017775
UWS Researchers: Gerald Muench
Funding:
  • University of Western Sydney
Title: Identification of anti-inflammatory and neuroprotective compounds from native Australian plants
Years: 2009-11-23 - 2012-03-31
ID: P00017131
UWS Researchers: Gerald Muench
Funding:
  • University of Western Sydney
  • Ecobiotics Limited
Title: Anti-inflammatory and Neuroprotective effects of Lipoic acid (LA) in the treatment of Alzheimer's Disease
Years: 2009-05-14 - 2011-12-31
ID: P00017177
UWS Researchers: Gerald Muench
Funding:
  • GeroNova Research Inc
Title: A longitudinal population-based cohort study of brain ageing - The Tasmanian Study of Cognition and Gait [via Monash Uni]
Years: 2008-01-01 - 2013-01-01
ID: P00016214
UWS Researchers: Gerald Muench
Funding:
  • National Health and Medical Research Council (ACRG)
Title: ALT-711 - a structural analog of thiamine (Vitamin B1) - a potential inhibitor of thiamine pyrophosphate synthesis?
Years: 2008-06-03 - 2011-12-31
ID: P00016215
UWS Researchers: Gerald Muench
Funding:
  • Synvista Therapeutics, Inc.
Title: Development of image analysis to automate research in neurodegenerative diseases
Years: 2010-02-10 - 2014-02-10
ID: P00018360
UWS Researchers: Gerald Muench
Funding:
  • Commonwealth Scientific & Industrial Research Organisation (CSIRO) (non ACRG)
Title: Molecular characterization of the anti-inflammatory activity of Andrographis paniculata
Years: 2010-11-30 - 2012-12-12
ID: P00019633
UWS Researchers: Nikolaus Sucher and Gerald Muench
Funding:
  • University of Western Sydney
Title: Screening for abdominal aortic aneurysms: long-term outcome and role of circulating markers of glycation [via UWA]
Years: 2011-01-01 - 2013-12-31
ID: P00018593
UWS Researchers: Gerald Muench
Funding:
  • National Health and Medical Research Council (ACRG)
Title: Investigation of protective health benefits of selected varieties of mushroom in relation to Alzheimer's disease [via CSIRO]
Years: 2009-09-01 - 2011-12-31
ID: P00017275
UWS Researchers: Gerald Muench
Funding:
  • Horticulture Australia Limited (ACRG)
Title: Glutathione delivery of astrocytes to Neurons as a target for therapeutic intervention in Alzheimer's disease
Years: 2011-01-01 - 2013-12-31
ID: P00018694
UWS Researchers: Gerald Muench
Funding:
  • Alzheimers Australia Research Limited

Supervision

Professor Muench is available to be a principal supervisor for doctoral projects

Current Supervision

Title: Phytoequivalence of Standardized Andrographis Paniculata Extracts: An In-depth Study of Molecular Immunomodulatory Effects
Field of Research:

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