Professor Jens Coorssen

Professor Jens Coorssen

CHAIR OF MOLECULAR PHYSIOLOGY,
School of Medicine

Personal

Qualifications

  • PhD McMaster University Ontario, Canada
  • MSc Brock University
  • BSc Brock University

UWS Organisational Unit (School / Division)

  • School of Medicine

Contact

Email:J.Coorssen@uws.edu.au
Extension:3802
Mobile:
Location:30.2.15
Campbelltown
Website:

Biography

Jens trained in Canada (BSc, MSc, PhD) with subsequent Fellowships at the Max Planck Institute for Medical Research (Heidelberg) and the National Institutes of Health (USA). Following a NIH Visiting Scientist appointment he was an Associate Professor in the Faculty of Medicine/Hotchkiss Brain Institute, University of Calgary. In 2008 he was appointed Foundation Professor of Molecular Physiology at the new School of Medicine, University of Western Sydney. The Molecular Physiology Unit operates on the philosophy that only by understanding essential molecular mechanisms can we rationally address serious medical disorders, and that this also provides the best strategy for training the next generations of Biomedical Researchers, Clinical Scientists, and Physicians. We strive to make our teaching and training the best possible preparation and guide for our students to become those future colleagues we hold in the highest esteem. Research operates at the interface of physiology, biochemistry, physical chemistry, molecular biology and biophysics, coupling functional assays/diagnoses with proteomic and lipid analyses to dissect molecular mechanisms. A strong, quantitative Basic Biomedical research program provides solid grounding for Translational Research that addresses problems of more immediate clinical relevance. Much of this work grows from and is supported by a variety of local and international collaborations.

This information has been contributed by Professor Coorssen.

Publications

Journal Articles

  • Rogasevskaia, T., Churchward, M., Coorssen, J. and Coorssen, J. (2012), 'Anionic lipids in Ca?+ -triggered fusion', Cell Calcium, 11.
  • Ormerod, K., Rogasevskaia, T., Coorssen, J., Coorssen, J. and Mercier, J. (2012), 'Cholesterol-independent effects of methyl-?-cyclodextrin on chemical synapses', PLoS ONE, .
  • Raveh, A., Valitsky, M., Shani, L., Coorssen, J., Coorssen, J., Blank, P., Zimmerberg, J. and Rahamimoff, R. (2012), 'Observations of calcium dynamics in cortical secretory vesicles', Cell Calcium, 9.
  • Gauci, V., Wright, E., Wright, E., Coorssen, J. and Coorssen, J. (2011), 'Quantitative proteomics: assessing the spectrum of in-gel protein detection methods', Journal of Chemical Biology, 27.
  • Lubieniecka, J., Foster, L., Grigliatti, T., Tetzlaff, W., Streijger, F., Lee, J., Stoynov, N., Liu, J., Mottus, R., Pfeifer, T., Kwon, B., Coorssen, J. and Coorssen, J. (2011), 'Biomarkers for severity of spinal cord injury in the cerebrospinal fluid of rats', PLoS ONE, .
  • Rogasevskaia, T., Coorssen, J. and Coorssen, J. (2011), 'A new approach to the molecular analysis of docking, priming, and regulated membrane fusion', Journal of Chemical Biology, 20.
  • Furber, K., Dean, K., Coorssen, J. and Coorssen, J. (2010), 'Dissecting the mechanism of Ca2+-triggered membrane fusion: Probing protein function using thiol reactivity', Clinical and Experimental Pharmacology and Physiology, 10.
  • Chasserot-Golaz, S., Coorssen, J., Coorssen, J., Meunier, F. and Vitale, N. (2010), 'Lipid dynamics in exocytosis', Cellular and Molecular Neurobiology, 8.
  • Furber, K., Churchward, M., Rogasevskaia, T., Coorssen, J. and Coorssen, J. (2009), 'Identifying Critical Components of Native Ca2+-triggered Membrane Fusion : Integrating Studies of Proteins and Lipids', Annals of the New York Academy of Sciences, 14.
  • Churchward, M., Coorssen, J. and Coorssen, J. (2009), 'Cholesterol, regulated exocytosis and the physiological fusion machine', Biochemical Journal, 14.
  • Zeng, Z., Yeoman, M., Wildering, W., Coorssen, J., Coorssen, J., Croll, R., Buck, L., Syed, N., Smit, A., Zhang, Z., van Kesteren, R., Straub, V., van Nierop, P., Jin, K., Nejatbakhsh, N., Goldberg, J. and Spencer, G. (2009), 'Transcriptome analysis of the central nervous system of the mollusc Lymnaea stagnalis', BMC Genomics, -450.
  • Furber, K., Brandman, D., Coorssen, J. and Coorssen, J. (2009), 'Enhancement of the Ca<sup>2+</sup>-triggering steps of native membrane fusion via thiol-reactivity', Journal of Chemical Biology, 11.
  • Churchward, M., Rogasevskaia, T., Brandman, D., Khosravani, H., Nava, P., Atkinson, J., Coorssen, J. and Coorssen, J. (2008), 'Specific lipids supply critical negative spontaneous curvature-an essential component of native Ca<sup>2+</sup>-triggered membrane fusion', Biophysical Journal, 11.
  • Churchward, M., Brandman, D., Rogasevskaia, T., Coorssen, J. and Coorssen, J. (2008), 'Copper (II) sulfate charring for high sensitivity on-plate fluorescent detection of lipids and sterols: Quantitative analyses of the composition of functional secretory vesicles', Journal of Chemical Biology, 9.
  • Harris, L., Churchward, M., Butt, R., Coorssen, J. and Coorssen, J. (2007), 'Assessing detection methods for gel-based proteomic analyses', Journal of Proteome Research, 8.
  • Butt, R., Pfeifer, T., Delaney, A., Griliatti, T., Tetzlaff, W., Coorssen, J. and Coorssen, J. (2007), 'Enabling coupled quantitative genomics and proteomics analyses from rat spinal cord samples', Molecular and Cellular Proteomics, 15.
  • Rahamimoff, R., Fendyur, A., Kaiserman, I., Raveh, A., Blank, P., Coorssen, J., Coorssen, J., Shani, L. and Zimmerberg, J. (2006), 'Regulation of transmitter release', Autonomic and Autacoid Pharmacology, 2.
  • Hibbert, J., Butt, R., Coorssen, J. and Coorssen, J. (2006), 'Actin is not an essential component in the mechanism of calcium-triggered vesicle fusion', International Journal of Biochemistry and Cell Biology, 11.
  • Rogasevskaia, T., Coorssen, J. and Coorssen, J. (2006), 'Sphingomyelin-enriched microdomains define the efficiency of native Ca<sup>2+</sup>-triggered membrane fusion', Journal of Cell Science, 7.
  • Taylor, R., Coorssen, J. and Coorssen, J. (2006), 'Proteome resolution by two-dimensional gel electrophoresis varies with the commercial source of IPG strips', Journal of Proteome Research, 9.
  • Butt, R., Lee, M., Pirshahid, S., Backlund, P., Wood, S., Coorssen, J. and Coorssen, J. (2006), 'An initial proteomic analysis of human preterm labor: Placental membranes', Journal of Proteome Research, 12.
  • Butt, R., Coorssen, J. and Coorssen, J. (2006), 'Pre-extraction sample handling by automated frozen disruption significantly improves subsequent proteomic analyses', Journal of Proteome Research, 12.
  • Bi, G., Galhardo, V., Gan, W., Gu, J., Inoue, K., Isaac, J., Iwata, K., Jia, Z., Kaang, B., Kawamata, M., Kida, S., Bolshakov, V., Klann, E., Kohno, T., Li, M., Li, X., MacDonald, J., Nader, K., Nguyen, P., Oh, U., Ren, K., Roder, J., Bu, G., Salter, M., Song, W., Sugita, S., Tang, S., Tao, Y., Tian, Y., Woo, N., Woodin, M., Yan, Z., Yoshimura, M., Cahill, C., Xu, M., Xu, Z., Zhang, X., Zhen, M., Zhuo, M., Chen, Z., Collingridge, G., Cooper, R., Coorssen, J., Coorssen, J. and El-Husseini, A. (2006), 'Recent advances in basic neurosciences and brain disease: From synapses to behavior', Molecular Pain, .
  • Howell, J., Winstone, T., Coorssen, J., Coorssen, J. and Turner, R. (2006), 'An evaluation of in vitro protein-protein interaction techniques: Assessing contaminating background proteins', Proteomics, 20.
  • Churchward, M., Rogasevskaia, T., Hofgen, J., Bau, J., Coorssen, J. and Coorssen, J. (2005), 'Cholesterol facilitates the native mechanism of Ca<sup>2+</sup>-triggered membrane fusion', Journal of Cell Science, 16.
  • Butt, R., Coorssen, J. and Coorssen, J. (2005), 'Postfractionation for enhanced proteomic analyses: Routine electrophoretic methods increase the resolution of standard 2D-PAGE', Journal of Proteome Research, 10.
  • Churchward, M., Butt, R., Lang, J., Hsu, K., Coorssen, J. and Coorssen, J. (2005), 'Enhanced detergent extraction for analysis of membrane proteomes by two-dimensional gel eletrophoresis', Proteome Science, .
  • Whalley, T., Timmers, K., Coorssen, J., Coorssen, J., Bezrukov, L., Kingsley, D. and Zimmerberg, J. (2004), 'Membrane fusion of secretory vesicles of the sea urchin egg in the absence of NSF', Journal of Cell Science, 12.
  • Szule, J., Coorssen, J. and Coorssen, J. (2003), 'Revisiting the role of SNAREs in exocytosis and membrane fusion', Biochimica et Biophysica Acta - Molecular Cell Research, 15.
  • Szule, J., Jarvis, S., Hibbert, J., Spafford, J., Braun, J., Zamponi, G., Wessel, G., Coorssen, J. and Coorssen, J. (2003), 'Calcium-triggered Membrane Fusion Proceeds Independently of Specific Presynaptic Proteins', Journal of Biological Chemistry, 4.
  • Coorssen, J., Coorssen, J., Blank, P., Albertorio, F., Bezrukov, L., Kolosova, I., Chen, X., Backlund, P. and Zimmerberg, J. (2003), 'Regulated secretion: SNARE density, vesicle fusion and calcium dependence', Journal of Cell Science, 11.
  • Coorssen, J., Coorssen, J., Blank, P., Albertorio, F., Bezrukov, L., Kolosova, I., Backlund, P. and Zimmerberg, J. (2002), 'Quantitative femto- to attomole immunodetection of regulated secretory vesicle proteins critical to exocytosis', Analytical Biochemistry, 9.
  • Yergey, A., Coorssen, J., Coorssen, J., Backlund, P., Blank, P., Humphrey, G., Zimmerberg, J., Campbell, J. and Vestal, M. (2002), 'De novo sequencing of peptides using MALDI/TOF-TOF', Journal of the American Society for Mass Spectrometry, 8.

Conference Papers

  • Szule, J., Churchward, M., Butt, R., Coorssen, J. and Coorssen, J. (2005), 'Cholesterol is an essential component of the minimal native fusion machine', 49th Biophysical Society Annual Meeting, .
  • Coorssen, J., Coorssen, J., Butt, R., Hibbert, J. and Szule, J. (2003), 'Integrated functional-molecular analyses to explore models of regulated membrane fusion', HUPO/IUBMB Meeting, Montreal.
  • Verma, A., Coorssen, J., Coorssen, J., Yin, S., Poustka, A., Blank, P., Backlund, P. and Zimmerberg, J. (2001), 'Identification of the calcium-binding proteins regulating the membrane fusion steps of exocytosis', American Society for Cell Biology Annual Meeting, .

Research

Current Projects

Title:Real-time analyses of single cell functions using electrophysiology: Dissecting the central mechanism of neuronal function
Years:2013-01-30 - 2013-12-31
ID:P00021413
UWS Researchers:Jens Coorssen and Jens Coorssen
Funding:
  • Rebecca L Cooper Medical Research Foundation Ltd
Title:Tritrichomonas foetus - Epithelial Interactions: dissecting the Roles of Attachment, Cytotoxicity and Host Factors in the Infection Process.
Years:2012-11-15 - 2013-12-15
ID:P00021251
UWS Researchers:Colin Stack, Jens Coorssen, Jens Coorssen and Graham Jones
Funding:
  • University of Western Sydney
Title:Phosphoproteins Critical to Ca2+-Triggered Exocytosis
Years:2011-11-17 - 2014-11-16
ID:P00020691
UWS Researchers:Jens Coorssen and Jens Coorssen
Funding:
  • Anonymous Donation
Title:Quantative analysis of differential gel electrophoresis (DIGE) - based protein detection
Years:2012-10-24 - 2013-11-24
ID:P00021134
UWS Researchers:Elise Wright, Jens Coorssen and Jens Coorssen
Funding:
  • University of Western Sydney

Previous Projects

Title:Establishment of a mass spectrometer facility for natural products and proteomics research and teaching at the College of Health and Science within the University of Western Sydney, Campbelltown campus
Years:2008-09-24 - 2010-09-15
ID:P00016326
UWS Researchers:Nikolaus Sucher, Jens Coorssen, Jens Coorssen, Bill Price, Gerald Muench, Andrew Shalliker, Vincent Higgins, Dennis Chang, Sabine Piller, Simon Myers, Colin Stack and Michelle Moffitt
Funding:
  • University of Western Sydney
Title:Proteome analysis of human preterm labour: dissecting molecular mechanisms
Years:2008-12-18 - 2010-01-31
ID:P00016509
UWS Researchers:Jens Coorssen and Jens Coorssen
Funding:
  • University of Western Sydney
Title:Roles of Native Membrane Matrix Components in Regulated Secretion
Years:2008-11-03 - 2010-01-31
ID:P00016531
UWS Researchers:Jens Coorssen and Jens Coorssen
Funding:
  • University of Western Sydney
Title:Cell and Protein Analysis Unit
Years:2009-09-22 - 2010-09-21
ID:P00017371
UWS Researchers:Simon Myers, Jens Coorssen, Jens Coorssen, Sabine Piller, Annemarie Hennessy, Janice Aldrich-Wright, Soon Lee and Gerald Muench
Funding:
  • University of Western Sydney
Title:International Efforts in Translational Medicine
Years:2009-10-28 - 2010-10-27
ID:P00017596
UWS Researchers:Jens Coorssen, Jens Coorssen, Annemarie Hennessy, Bradley Frankum, Gerald Muench, Joanne Lind, Simon Myers and Soon Lee
Funding:
  • University of Western Sydney
Title:Beyond Proteomics: structure and function of protein modifications [via Macquarie Uni]
Years:2010-01-01 - 2010-12-31
ID:P00017151
UWS Researchers:Jens Coorssen and Jens Coorssen
Funding:
  • Australian Research Council (non ACRG)
Title:Cholesterol is a critical component in the mechanism of Ca2+ triggered membrane fusion
Years:2010-12-23 - 2011-12-22
ID:P00020040
UWS Researchers:Jens Coorssen and Jens Coorssen
Funding:
  • University of Western Sydney
Title:Fluorescence microscopy with optical tweezers: imaging cellular responses [via UNSW - no funding to UWS]
Years:2011-01-01 - 2011-12-31
ID:P00018999
UWS Researchers:Jens Coorssen and Jens Coorssen
Funding:
  • Australian Research Council (non ACRG)

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