
Professor Soon Lee
CHAIR OF PATHOLOGY,
School of Medicine
Personal
Qualifications
- PhD University of Melbourne
- MBBS University of Melbourne
UWS Organisational Unit (School / Division)
- School of Medicine
Contact
| Email: | soon.lee@uws.edu.au |
|---|---|
| Extension: | 6858 |
| Mobile: | |
| Location: | Off Campus |
| Website: |
Biography
MD BS (Melb), FRCPA, FRCPath (UK), MIAC, MRACMA. Professor Lee is Professor and Chair of Pathology at University of Western Sydney. He is currently based at Liverpool Hospital and is a senior pathologist at that hospital and at Royal Prince Alfred Hospital. He has research interests in cancer pathology particularly in relation to translational work in gastrointestinal, breast, pancreatic-biliary, head and neck and prostate cancers. His work on EGFR in head and neck cancers in the early 1990's resulted in the first and only one of two publications in this area in Australia that has recently resulted in the use of immunohistochemical detection of EGFR in patients with these cancers. His involvement in multicentre international study on phyllodes tumour of the breast has produced significant insights into the molecular basis of this unusual condition. He and his overseas collaborators from Hong Kong, Singapore and Brazil currently have the largest archival series of these tumours in the world. Professor Lee is currently Editor-in-Chief of the journal, Pathology (SCI impact factor of 1.77 in 2007) and is a member of the editorial board of the Journal of Clinical Pathology. He is also Associate Editor of the journal, Internet Journal of Oncology. He has published over 120 manuscripts in high impact factor international journals in cancer research. His research programmes are currently funded by NHMRC, Cancer Institute NSW, Cancer Australia and Royal Australian and New Zealand College of Radiologists.
This information has been contributed by Professor Lee.
Publications
Journal Articles
- Clarke, R. and Lee, C. (2013), 'Smg1 haploinsufficiency predisposes to tumor formation and inflammation', Proceedings of the National Academy of Sciences of the United States of America, 10.
- Clarke, R. and Lee, C. (2013), 'Smg1 haploinsufficiency predisposes to tumor formation and inflammation', Proceedings of the National Academy of Sciences of USA, 10.
- Chetty, R., Jaynes, E., Lee, C., Locketz, M., Rowsell, C., Rullier, A., Serra, S., Shepherd, N., Szentgyorgyi, E., Vajpeyi, R., Wang, L., Gill, P., Bateman, A., Govender, D., Bateman, A., Chang, H., Deshpande, V., Driman, D., Gomez, M. and Greywoode, G. (2012), 'International study group on rectal cancer regression grading : interobserver variability with commonly used regression grading systems', Human Pathology, 7.
- Chetty, R., Lee, S., Lee, C., Locketz, M., Mescoli, C., Rowsell, C., Rullier, A., Serra, S., Shepherd, N., Szentgyorgyi, E., Vajpeyi, R., Wang, L., Gill, P., Govender, D., Bateman, A., Chang, H., Driman, D., Duthie, F., Gomez, M. and Jaynes, E. (2012), 'A multi-centre pathologist survey on pathological processing and regression grading of colorectal cancer resection specimens treated by neoadjuvant chemoradiation', Virchows Archiv, 5.
- Hong, A., Elliott, M., Milross, C., Smee, R., Corry, J., Liu, C., Porceddu, S., Vaska, K., Veness, M., Morgan, G., Fogarty, G., Martin, A., Veivers, D., Rees, G., Rose, B., Armstrong, B., Lee, S., Jones, D., Chatfield, M., Zhang, M., Harnett, G. and Clark, J. (2012), 'Human papillomavirus modifies the prognostic significance of T stage and possibly N stage in tonsillar cancer', Annals of Oncology, 5.
- Killingsworth, M., Lai, K., Wu, X., Yong, J., Yong, J. and Lee, S. (2012), 'Quantum dot immunocytochemical localization of somatostatin in somatostatinoma by widefield epifluorescence, super-resolution light, and immunoelectron micrsocopy', Journal of Histochemistry and Cytochemistry, 12.
- Tsang, J., Mendoza, P., Putti, T., Karim, R., Scolyer, R., Lee, S., Pang, A. and Tse, G. (2012), 'E-caherin expression in the epithelial components of mammary phyllodes tumors', Human Pathology, 7.
- Clarke, R., Lee, C. and Eapen, V. (2012), 'Pathogenetic model for Tourette syndrome delineates overlap with related neurodevelopmental disorders including autism', Translational Psychiatry, .
- Lee, C. (2012), 'Involvement of a- and ?-catenins and E-cadherin in the development of mammary phyllodes tumours', Histopathology, 8.
- Allen, B., Lee, S. and Clarke, R. (2012), 'Orthotopic administration of 213Bi-bevacizumab inhibits progression of PC3 xenografts in the prostate', Immunotherapy, 6.
- Hong, A., Tran, N., Peculis, L., Ng, C., Milne, A., Loo, C., Hughes, L., Forstner, D., O'Brien, C., Rose, B., Dobbins, T., Lee, S., Jones, D., Fei, J., Clark, J., Armstrong, B., Harnett, G. and Milross, C. (2011), 'Use of cyclin D1 in conjunction with human papillomavirus status to predict outcome in oropharyngeal cancer', International Journal of Cancer, 14.
- Yip, P., Kench, J., Rasiah, K., Benito, R., Lee, S., Stricker, P., Henshall, S., Sutherland, R. and Horvath, L. (2011), 'Low AZGP1 expression predicts for recurrence in margin-positive, localized prostate cancer', Prostate, 8.
- Hollingsworth, J., Cooper, W., Nicolls, K., Wills, E., Thiruvilangam, V., Lee, S. and Scolyer, R. (2011), 'Follicular dendritic cell sarcoma of the lung: a report of two cases highlighting its pathological features and diagnostic pitfalls', Pathology, 4.
- Shin, J., Jalaludin, B., Solomon, M., Hong, A. and Lee, S. (2011), 'Histopathological regression grading versus staging of rectal cancer following radiotherapy', Pathology, 7.
- Murphy, N., Fox, S., Morey, A., Christie, M., Musgrove, E., Daly, R., Linderman, G., Henshall, S., Visvader, J., Sutherland, R., Biankin, A., Millar, E., Mcneil, C., O'Toole, S., Segara, D., Crea, P., Olayioye, M. and Lee, S. (2010), 'Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status', International Journal of Cancer, 9.
- Hong, A., O'Brien, C., Rose, B., Dobbins, T., Lee, S., Jones, D., Jackson, E., Clark, J., Armstrong, B., Harnett, G. and Milross, C. (2010), 'Relationships between epidermal growth factor receptor expression and human papillomavirus status as markers of prognosis in oropharyngeal cancer', European Journal of Cancer, 9.
- Huang, K., Dobrovic, A., Yan, M., Karim, R., Lee, S., Lakhani, S. and Fox, S. (2010), 'DNA methylation profiling of phyllodes and fibroadenoma tumours of the breast', Breast Cancer Research and Treatment, 11.
- Hong, A., O'Brien, C., Rose, B., Grulich, A., Jones, D., Lee, S., Garland, S., Dobbins, T., Clark, J., Harnett, G. and Milross, C. (2010), 'Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets', Vaccine, 4.
- Karim, R., Gerega, S., Yang, Y., Spillane, A., Carmalt, H., Scolyer, R. and Lee, S. (2010), 'p16 and pRb immunohistochemical expression increases with increasing tumour grade in mammary phyllodes tumours', Histopathology, 8.
- Hong, A., O'Brien, C., Rose, B., Dobbins, T., Lee, S., Jones, D., Harnett, G., Armstrong, B., Clark, J., Milross, C. and Kim, J. (2010), 'Human papillomavirus predicts outcomes in oropharyngeal cancer in patients treated with surgery or radiation therapy', British Journal of Cancer, 8.
- Sharma, S., Shin, J., Grimshaw, M., Clarke, R. and Lee, S. (2010), 'The senescence pathway in prostatic carcinogenesis', Pathology, 5.
- Hong, A. and Lee, S. (2010), 'Australian data show increase', British Medical Journal, 1.
- Zardawi, S., Lopez-Knowles, E., Oakes, S., Ormandy, C., Qiu, M., Hamilton, A., Spillane, A., Lee, S., Sutherland, R., Musgrove, E., O'Toole, S., Zardawi, I., Mcneil, C., Millar, E., Mcleod, D., Morey, A., Crea, P., Murphy, N. and Pinese, M. (2010), 'High Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtype', Histopathology, 11.
- Lee, S. (2009), 'Pathology: the story so far', Pathology, 2.
- Karim, R., Scolyer, R., Tse, G., Tan, P., Putti, T. and Lee, S. (2009), 'Pathogenic mechanisms in the initiation and progression of mammary phyllodes tumour', Pathology, 13.
- Yu, D., McCaughan, G., Gorrell, M., Ajami, K., Gall, M., Park, J., Lee, S., Evans, K., McLaughlin, E., Pitman, M. and Abbott, C. (2009), 'The In Vivo Expression of Dipeptidyl peptidases 8 and 9', Journal of Histochemistry & Cytochemistry, 16.
- Fei, J., O'Brien, C., Rose, B., Hong, A., Dobbins, T., Jones, D., Lee, S., Loo, C., Al-Ghamdi, M., Harnett, G. and Clarke, J. (2009), 'Prognostic Significance of Vascular Endothelial Growth Factor in Squamous Cell Carcinomas of the Tonsil in Relation to Human Papillomavirus Status and Epidermal Growth Factor Receptor', Annals of Surgical Oncology, 10.
- Bennett, N., Hooper, J., Lee, S. and Gobe, G. (2009), 'Androgen Receptor and Caveolin-1 in Prostate Cancer', IUBMB LIFE, 10.
- Karim, R., Gerega, S., Yang, Y., Spillane, A., Carmalt, H., Scolyer, R. and Lee, S. (2009), 'Phyllodes tumours of the breast: A clinicopathological analysis of 65 cases from a single institution', The Breast, 6.
- Cooper, W., Kohonen-Corish, M., Mccaughan, B., Kennedy, C., Sutherland, R. and Lee, S. (2009), 'Expression and prognostic significance of cyclin B1 and cyclin A in non-small cell lung cancer', Histopathology, 9.
- Karim, R., Gerega, S., Yang, Y., Horvath, L., Spilane, A., Carmalt, H., Scolyer, R. and Lee, S. (2009), 'Proteins from the Wnt pathway are involved in the pathogenesis and progression of mammary phyllodes tumours', Journal of Clinical Pathology, 5.
- Wong, M., Dobbins, T., Tseung, J., Tran, N., Lee, S., O'Brien, C. and Clark, J. (2009), 'Oestrogen receptor B expression in pleomorphic adenomas of the parotid gland', Journal of Clinical Pathology, 5.
- Zhuang, L., Scolyer, R., Lee, S., Mccarthy, S., Cooper, W., Zhang, X., Thompson, J. and Hersey, P. (2009), 'Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma', Histopathology, 9.
- Tse, G., Ng, D., Tse, A., Tan, P., Lui, P., Vong, J., Lau, K., Putti, T., Karim, R., Scolyer, R., Lee, S. and Yu, A. (2009), 'Increased epidermal growth factor receptor (EGFR) expression in malignant mammay phyllodes tumors', Breast Cancer Research and Treatment, 8.
- Biankin, A., Pinese, M., Kuo, S., Susanto, J., Cosman, P., Lindemann, G., Visvader, J., Nguyen, T., Merrett, N., Warusavitarne, J., Musgrove, E., Kench, J., Henshall, S., Sutherland, R., Colvin, E., Segara, D., Scarlett, C., Nguyen, N., Chang, D., Morey, A. and Lee, S. (2009), 'Expression of S100A2 Calcium-Binding Protein Predicts Response to Pancreatectomy for Pancreatic Cancer', Gastroenterology, 11.
- Lee, S. (2008), 'Pathology in its fortieth year', Pathology, 2.
- Doubrovsky, A., Scolyer, R., Murali, R., Mckenzie, P., Watson, G., Lee, S. and + 6 Externals, . (2008), 'Diagnostic Accuracy of Fine Needle Biopsy for Metastatic Melanoma and Its Implications for Patient Management', Annals of Surgical Oncology, 10.
- Seng, T., Currey, N., Cooper, W., Lee, S., Chan, C., Horvath, L. and + 4 Externals, . (2008), 'DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma', British Journal of Cancer, 8.
- Murali, R., Sharma, R., Thompson, J., Stretch, J., Lee, S., Mccarthy, S. and Scolyer, R. (2008), 'Sentinel Lymph Node Biopsy in Histologically Ambiguous Melanocytic Tumors With Spitzoid Features (So-Called Atypical Spitzoid Tumors)', Annals of Surgical Oncology, 8.
- Cooper, W., Kohonen-Corish, M., Chan, C., Kwun, S., Mccaughan, B., Kennedy, C., Sutherland, R. and Lee, S. (2008), 'Prognostic significance of DNA repair proteins MLH1, MSH2 and MGMT expression in non-small-cell lung cancer and precursor lesions', Histopathology, 10.
- Murphy, N., Scarlett, C., Kench, J., Sun, E., Colvin, E., Lee, S. and + 9 Externals, . (2008), 'Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma', British Journal of Cancer, 5.
- Cooper, W., Kohonen-Corish, M., Zhuang, L., Mccaughan, B., Kennedy, C., Screaton, G., Sutherland, R. and Lee, S. (2008), 'Role and Prognostic Significance of Tumor Necrosis Factor-related Apoptosis-inducing Ligand Death Receptor DR5 in Nonsmall-Cell Lung Cancer and Precursor Lesions', Cancer, 8.
- Zhuang, L., Lee, S., Scolyer, R., Mccarthy, S., Zhang, X., Thompson, J. and Hesey, P. (2007), 'Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma', Modern Pathology, 11.
- Horvath, L., Lelliott, J., Kench, J., Lee, S., Williams, E., Saunders, D., Grygiel, J. and Sutherland, R. (2007), 'Secreted Frizzled-Related Protein 4 Inhibits Proliferation and Metastatic Potential in Prostate Cancer', The Prostate, 10.
- Patel, R., Rose, B., Bawdon, H., Hong, A., Lee, S., Fredericks, S., Gao, K. and O'Brien, C. (2007), 'Cyclin D1 and p16 expression in pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid gland', Histopathology, 6.
- Murali, R., Doubrovsky, A., Watson, G., Mckenzie, P., Lee, S., Mcleod, D., Uren, R. and Stretch, J. (2007), 'Diagnosis of Metastatic Melanoma by Fine-Needle Biopsy: Analysis of 2,204 Cases', American Journal of Clinical Pathology, 13.
- Tse, G., Chaiwun, B., Lau, K., Scolyer, R., Lee, S., Karim, R., Putti, T. and Law, B. (2007), 'Endothelin-1 expression correlates with atypical histological features in mammary phyllodes tumours', Journal of Clinical Pathology, 6.
- Patel, R., Hughes, C., Fredericks, S., Lee, S., Rose, B., Gao, K., Smith, G. and Hong, A. (2007), 'Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland', Histopathology, 5.
- Li, W., Tran, N., Lee, S., O'Brien, C., Tse, G., Scolyer, R., Hong, A. and Milross, C. (2007), 'New evidence of geographic variation in the role of human papillomavirus in tonsillar carcinogenesis', Pathology, 6.
- Kaufman, A., Storey, D., Lee, S. and Murali, R. (2007), 'Mucinous cyst exhibiting severe dysplasia in gastric heterotophic pancreasw associated with gastrointestinal stromal tumour', World Journal of Gastroenterology, 2.
- Cooper, C., Joshua, D., Lee, S., Eyers, A. and Cooper, W. (2007), 'Extranodal plasmablastic lymphoma arising in mantle cell lymphoma [6]', Histopathology, 4.
- Shin, J., Hong, A., Solomon, M. and Lee, S. (2006), 'The role of telomeres and telomerase in the pathology of human cancer and ageing', Pathology, 11.
- Zhuang, L., Lee, S., Scolyer, R., Mccarthy, S., Zhang, X., Thompson, J., Screaton, G. and Hersey, P. (2006), 'Progression in melanoma is associated with decreased expression of death receptors for tumor necrosis factor-related apoptosis-inducing ligand', Human Pathology, 9.
- Rasiah, K., Kench, J., Gardiner-Garden, M., Biankin, A., Golovsky, D., Brenner, P., Kooner, R. and Lee, S. (2006), 'Aberrant Neuropeptide Y and Macrophage Inhibitory Cytokine-1 Expression Are Early Events in Prostate Cancer Development and Are Associated with Poor Prognosis', Cancer Epidemiol Biomarkers & Prevention, 6.
- Ellmark, P., Belov, L., Huang, P., Lee, S., Solomon, M., Morgan, D. and Christopherson, R. (2006), 'Multiplex detection of surface molecules on colorectal cancers', Proteomics, 12.
- Li, W., Sanki, A., Karim, R., Thompson, J., Lee, S., Zhuang, L., Mccarthy, S. and Scolyer, R. (2006), 'The role of cell cycle regulatory proteins in the pathogenesis of melanoma', Pathology, 15.
- Seddiki, N., Santner-Nanan, B., Tangye, S., Alexander, S., Solomon, M., Lee, S., Nanan, R. and Fazekas De Saint Groth, B. (2006), 'Persistence of naive CD43RA+regulatory T cells in adult life', Blood, 9.
- Kirkham, B., Lassere, M., Edmonds, J., Juhasz, K., Bird, P., Lee, S., Shnier, R. and Portek, I. (2006), 'Synovial Membrane Cytokine Expression Is Predictive of Joint Damage Progression in Rheumatoid Arthritis. A Two-Year Prospective Study (the DAMAGE Study Cohort)', Arthritis & Rheumatism, 10.
- Zhuang, L., Lee, S., Scolyer, R., Mccarthy, S., Palmer, A., Zhang, X., Thompson, J. and Bron, L. (2005), 'Activation of the extracellular signal regulated kinase (ERK) pathway in human melanoma', Journal of Clinical Pathology, 7.
- Murphy, N., Millar, E. and Lee, S. (2005), 'Gene expression profiling in breast cancer: towards individualising patient management', Pathology, 7.
- Lee, S. (2005), 'Breast cancer pathology', Pathology, 2.
- Tse, G., Wong, F., Tsang, A., Lee, S., Lui, P., Lo, A., Law, B. and Scolyer, R. (2005), 'Stromal nitric oxide synthase (NOS) expression correlates with the grade of mammary phyllodes tumour', Journal of Clinical Pathology, 5.
- Tse, G., Tsang, A., Putti, T., Scolyer, R., Lui, P., Law, B., Karim, R. and Lee, S. (2005), 'Stromal CD10 expression in mammary fibroadenomas and phyllodes tumours', Journal of Clinical Pathology, 5.
- Horvath, L., Grygiel, J., Sutherland, R., Henshall, S., Lee, S., Kench, J., Golovsky, D., Brenner, P., O'Neill, G., Kooner, R. and Stricker, P. (2005), 'Lower levels of Nuclear Beta-Catenin Predict for a Poorer Prognosis in Localized Prostate Cancer', Internal Journal of Cancer, 8.
- Clarke, R., Fang, Z., Lee, S., Sarris, M., Murrell, D. and Kearsley, J. (2002), 'Multiple sclerosis in a radiosensitive family with low levels of the ATM protein', Australasian Radiology, 8.
- Ren, Z., Pang, G., Clancy, R., Li, L., Lee, S., Batey, R., Borody, T. and Dunkley, M. (2001), 'Shift of the gastric T-cell response in gastric carcinoma', Journal of Gastroenterology and Hepatology, 7.
Conference Papers
- Shin, J., Zhou, J., Belov, L., Zhang, M., Hong, A., Solomon, M., Christopherson, R. and Lee, S. (2009), 'Comparison of Radiosensitivity and Cell Membrane Proteome between Microsatellite stable and unstable colorectal cancers - an In Vitro study with A 122 antibody microarray', RCPA Pathology Update, Sydney.
Research
Current Projects
| Title: | Translational Cancer Research Clinical Fellowship [via Ingham Institute] |
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| Years: | 2013-02-01 - 2014-01-31 |
| ID: | P00021286 |
| UWS Researchers: | Soon Lee |
| Funding: |
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| Title: | Optimising molecular profiling for prostate cancer detection and diagnosis |
| Years: | 2012-11-15 - 2013-12-15 |
| ID: | P00021212 |
| UWS Researchers: | Raymond Clarke and Soon Lee |
| Funding: |
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| Title: | Brm and Brg-1 protect from ultraviolet radiation-induced skin and ocular damage [via USYD - no funding to UWS] |
| Years: | 2010-01-01 - 2013-12-31 |
| ID: | P00017780 |
| UWS Researchers: | Soon Lee |
| Funding: |
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| Title: | Modulating cholesterol-dependent lipid rafts and caveolin in prostate cancer therapy [via University of Qld - no funding to UWS] |
| Years: | 2010-10-01 - 2013-09-30 |
| ID: | P00018511 |
| UWS Researchers: | Soon Lee |
| Funding: |
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| Title: | Molecular Cancer Pathology Scholarship [via Ingham Institute for Applied Medical Research] |
| Years: | 2011-10-17 - 2014-10-16 |
| ID: | P00020992 |
| UWS Researchers: | Soon Lee |
| Funding: |
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Previous Projects
| Title: | Cell and Protein Analysis Unit |
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| Years: | 2009-09-22 - 2010-09-21 |
| ID: | P00017371 |
| UWS Researchers: | Simon Myers, Jens Coorssen, Jens Coorssen, Sabine Piller, Annemarie Hennessy, Janice Aldrich-Wright, Soon Lee and Gerald Muench |
| Funding: |
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| Title: | Analysis for differentially expressed proteins in radiation sensitive and resistant rectal cancer cells [via SSWAHS - no funding to UWS] |
| Years: | 2010-01-01 - 2011-12-31 |
| ID: | P00017457 |
| UWS Researchers: | Soon Lee |
| Funding: |
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| Title: | International Efforts in Translational Medicine |
| Years: | 2009-10-28 - 2010-10-27 |
| ID: | P00017596 |
| UWS Researchers: | Jens Coorssen, Jens Coorssen, Annemarie Hennessy, Bradley Frankum, Gerald Muench, Joanne Lind, Simon Myers and Soon Lee |
| Funding: |
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| Title: | Breast Cancer Tissue Bank - data collection and management infrastructure [via USYD - no funding to UWS] |
| Years: | 2009-07-01 - 2012-06-30 |
| ID: | P00017458 |
| UWS Researchers: | Soon Lee |
| Funding: |
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| Title: | PALM Microbeam Laser Microdissection (LM) Microscope for the Multi-User Sydney Cancer Gene Expression Facility [via Bosch Institute, USYD - no funding to UWS] |
| Years: | 2009-07-01 - 2012-06-30 |
| ID: | P00017459 |
| UWS Researchers: | Soon Lee |
| Funding: |
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| Title: | Evaluation of antibody targeted a-therapy for prostate cancer in a new mouse model |
| Years: | 2010-11-30 - 2012-02-29 |
| ID: | P00019600 |
| UWS Researchers: | Raymond Clarke and Soon Lee |
| Funding: |
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| Title: | Investigation of biomarkers for the diagnosis and prognosis of common cancers in the community such as breast, colorectal, prostate and head and neck cancers |
| Years: | 2011-01-01 - 2012-12-31 |
| ID: | P00018651 |
| UWS Researchers: | Soon Lee and Yi Qiu Sun |
| Funding: |
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| Title: | South West Sydney Translational Cancer Research Unit [via Ingham Institute for Applied Medical Research] |
| Years: | 2012-02-27 - 2013-02-26 |
| ID: | P00020939 |
| UWS Researchers: | Paul De Souza, Soon Lee and Les Bokey |
| Funding: |
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