Professor Vaughan Macefield

Journal Articles

• Brown, R. and Macefield, V. (2013), 'Inhibition of augmented muscle vasoconstrictor drive following asphyxic apnoea in awake human subjects is not affected by relief of chemical drive', Experimental Physiology, 10.
• Macefield, V. (2013), 'Discharge rates and discharge variability of muscle spindle afferents in human chronic spinal cord injury', Clinical Neurophysiology, 6.
• Macefield, V. (2013), 'Cardiac-locked bursts of muscle sympathetic nerve activity are absent in familial dysautonomia', Journal of Physiology, 12.
• Macefield, V. (2013), 'Real-time imaging of cortical and subcortical control of muscle sympathetic nerve activity in awake human subjects', Neuroimage, 7.
• Macefield, V. (2013), 'Viscerosympathetic reflexes in human spinal cord injury : relationships between detrusor pressure, blood pressure and skin blood flow during bladder distension', Experimental Physiology, 11.
• Macefield, V. and Birznieks, I. (2013), 'Tonic muscle pain does not increase fusimotor drive to human leg muscles : implications for chronic muscle pain', Experimental Physiology, 8.
• Macefield, V. (2013), 'Real-time imaging of brain areas involved in the generation of spontaneous skin sympathetic nerve activity at rest', NeuroImage, 7.
• Chan, G., Fazalbhoy, A., Birznieks, I., Macefield, V., Middleton, P. and Lovell, N. (2012), 'Spontaneous fluctuations in peripheral photoplethysmographic waveform: roles of arterial pressure and muscle sympathetic nerve activity', Am J Physiol Heart Circ Physiol., 11.
• Birznieks, I., Boonstra, T. and Macefield, V. (2012), 'Modulation of human muscle spindle discharge by arterial pulsations : functional effects and consequences', PLoS ONE, .
• Grewal, T., Dawood, T., Dawood, T., Hammam, E., Kwok, K., Macefield, V. and Macfield, V. (2012), 'Low-frequency physiological activation of the vestibular utricle causes biphasic modulation of skin sympathetic nerve activity in humans', Experimental Brain Research, 8.
• Brown, R., Brown, R., James, C., Henderson, L. and Macefield, V. (2012), 'Autonomic markers of emotional processing: Skin sympathetic nerve activity in humans during exposure to emotionally charges images', Frontiers in Physiology, 6.
• Hall, S., Fazalbhoy, A., Birznieks, I. and Macefield, V. (2012), 'Biphasic effects of tonic stimulation of muscle nociceptors on skin sympathetic nerve activity in human subjects', Exp Brain Res, 8.
• Fazalbhoy, A., Birznieks, I. and Macefield, V. (2012), 'Individual differences in the cardiovascular responses to tonic muscle pain: parallel increases or decreases in muscle sympathetic nerve activity, blood pressure and heart rate.', Experimental Physiology, 9.
• Brown, R., Duma, S., Piguet, O., Broe, A. and Macefield, V. (2012), 'Cardiovascular variability in Parkinson's disease and extrapyramidal motor slowing', Clinical Autonomic Research, 6.
• Chan, G., Fazalbhoy, A., Birznieks, I., Macefield, V., Middleton, P. and Lovell, N. (2012), 'Spontaneous fluctuations in the peripheral photoplethysmographic waveform : roles of arterial pressure and muscle sympathetic nerve activity', American Journal of Physiology: Heart and Circulatory Physiology, 11.
• Hall, S., Fazalbhoy, A., Birznieks, I. and Macefield, V. (2012), 'Biphasic effects of tonic stimulation of muscle nociceptors on skin sympathetic nerve activity in human subjects', Experimental Brain Research, 8.
• Grewal, T., Dawood, T., Hammam, E., Kwok, K. and Macefield, V. (2012), 'Low-frequency physiological activation of the vestibular utricle causes biphasic modulation of skin sympathetic nerve activity in humans', Experimental Brain Research, 8.
• Birznieks, I., Boonstra, T. and Macefield, V. (2012), 'Modulation of human muscle spindle discharge by arterial pulsations : functional effects and consequences', PLoS ONE, .
• Henderson, L., James, C. and Macefield, V. (2012), 'Identification of sites of sympathetic outflow during concurrent recordings of sympathetic nerve activity and fMRI', Anatomical Record, 8.
• Henderson, L., Stathis, A., James, C., Brown, R., McDonald, S. and Macefield, V. (2012), 'Real-time imaging of cortical areas involved in the generation of increases in skin sympathetic nerve activity when viewing emotionally charged images', NeuroImage, 11.
• El Sayed, K., Dawood, T., Hammam, E. and Macefield, V. (2012), 'Evidence from bilateral recordings of sympathetic nerve activity for lateralisation of vestibular contributions to cardiovascular control', Experimental Brain Research, 10.
• Fazalbhoy, A., Birznieks, I. and Macefield, V. (2012), 'Individual differences in the cardiovascular responses to tonic muscle pain : parallel increases or decreases in muscle sympathetic nerve activity, blood pressure and heart rate', Experimental Physiology, 9.
• Macefield, V. (2012), 'Firing patterns of muscle vasoconstrictor neurons in respiratory disease', Frontiers in Physiology, .
• Macefield, V., Burton, A. and Brown, R. (2012), 'Somatosympathetic vasoconstrictor reflexes in human spinal cord injury : responses to innocuous and noxious sensory stimulation below lesion', Frontiers in Physiology, .
• Brown, R., James, C., Henderson, L. and Macefield, V. (2012), 'Autonomic markers of emotional processing : skin sympathetic nerve activity in humans during exposure to emotionally charged images', Frontiers in Physiology, 6.
• Birznieks, I. and Macefield, V. (2012), 'Biphasic effects of tonic muscle pain on skin sympathetic nerve activity in human subjects', Experimental Brain Research, 8.
• Macefield, V. (2012), 'Low-frequency galvanic vestibular stimulation evokes two peaks of modulation in skin sympathetic nerve activity', Experimental Brain Research, 6.
• Macefield, V. (2012), 'Low-frequency galvanic vestibular stimulation evokes two peaks of modulation in skin sympathetic nerve activity', Experimental Brain Research, 6.
• Henderson, L., Rubin, T. and Macefield, V. (2011), 'Within-limb somatotopic representation of acute muscle pain in the human contralateral dorsal posterior insula', Human Brain Mapping, 10.
• Hammam, E., James, C., Dawood, T. and Macefield, V. (2011), 'Low-frequency sinusoidal galvanic stimulation of the left and right vestibular nerves reveals two peaks of modulation in muscle sympathetic nerve activity', Experimental Brain Research, 8.
• Macefield, V. and Macefield, V. (2011), 'On the number of preganglionic neurons driving human postganglionic sympathetic neurons: a comparison of modeling and empirical data', Frontiers in Neuroscience, 6.
• Macefield, V., Macefield, V., Norcliffe-Kaufmann, L., Gutierrez, J., Axelrod, F. and Kaufmann, H. (2011), 'Can loss of muscle spindle afferents explain the ataxic gait in Riley-Day syndrome?', Brain, 11.
• Fatouleh, R., Macefield, V. and Macefield, V. (2011), 'Respiratory modulation of muscle sympathetic nerve activity is not increased in essential hypertension or chronic obstructive pulmonary disease', Journal of Physiology, 10.
• Hammam, E., James, C., Dawood, T., Macefield, V. and Macefield, V. (2011), 'Low-frequency sinusoidal galvanic stimulation of the left and right vestibular nerves reveals two peaks of modulation in muscle sympathetic nerve activity', Experimental Brain Research, 8.
• Nagi, S., Nagi, S., Rubin, T., Chelvanayagam, D., Chelvanayagam, D., Macefield, V., Macefield, V., Mahns, D. and Mahns, D. (2011), 'Allodynia mediated by C-tactile afferents in human hairy skin', Journal of Physiology, 11.
• Macefield, V. and Henderson, L. (2010), 'Real-time imaging of the medullary circuitry involved in the generation of spontaneous muscle sympathetic nerve activity in awake subjects', Human Brain Mapping, 11.
• Ashley, C., Burton, D., Sverrisdottir, Y., Sander, M., Mckenzie, D. and Macefield, V. (2010), 'Firing probability and mean firing rates of human muscle vasoconstrictor neurones are elevated during chronic asphyxia', The Journal of Physiology, 11.
• Sander, M., Macefield, V. and Henderson, L. (2010), 'Cortical and brain stem changes in neural activity during static handgrip and post-exercise ischemia in humans', Journal of Applied Physiology, 10.
• Rubin, T., Henderson, L. and Macefield, V. (2010), 'Changes in the spatiotemporal expression of local and referred pain following repeated intramuscular injections of hypertonic saline: a longtitudinal study', The Journal of Pain, 9.
• James, C., Stahis, A. and Macefield, V. (2010), 'Vestibular and pulse-related modulation of skin sympathetic nerve activity during sinusoidal galvanic vestibular stimulation in human subjects', Experimental Brain Research, 8.
• James, C. and Macefield, V. (2010), 'Competitive interactions between vestibular and cardiac rhythms in the modulation of muscle sympathetic nerve activity', Autonomic Neuroscience: Basic & Clinical, 5.
• Nash, P., Macefield, V., Klineberg, I., Gustin, S., Murray, G. and Henderson, L. (2010), 'Changes in human primary motor cortex activity during acute cutaneous and muscle orofacial pain', Journal of Orofacial Pain, 12.
• Nash, P., Macefield, V., Klineberg, I., Gustin, S., Murray, G. and Henderson, L. (2010), 'Bilateral activation of the trigeminothalamic tract by acute orofacial cutaneous and muscle pain in humans', Pain, 10.
• Wrigley, P., Press, S., Gustin, S., Macefield, V., Gandevia, S., Cousins, M., Middleton, J., Henderson, L. and Siddall, P. (2009), 'Neuropathic pain and primary somatosensory cortex reorganisation following spinal cord injury', Pain, 8.
• Burton, A., Birznieks, I., Bolton, P., Henderson, L. and Macefield, V. (2009), 'Effects of deep and superficial experimentally induced acute pain on muscle sympathetic nerve activity in human subjects', Journal of Physiology, 11.
• Wrigley, P., Gustin, S., Macey, P., Nash, P., Gandevia, S., Macefield, V., Siddall, P. and Henderson, L. (2009), 'Anatomical changes in human motor cortex and motor pathways following complete thoracic spinal cord injury', Cerebral Cortex, 9.
• Rubin, T., Gandevia, S., Henderson, L. and Macefield, V. (2009), 'Effects of Intramuscular Anesthesia on the Expression of Primary and Referred Pain Induced by Intramuscular Injection of Hypertonic Saline', Journal of Pain, 7.
• Birznieks, I., Macefield, V., Westling, G. and Johansson, R. (2009), 'Slowly adapting mechanoreceptors in the borders of the human fingernail encode fingertip forces', Journal of Neuroscience, 10.
• Nash, P., Macefield, V., Klineberg, I., Murray, G. and Henderson, L. (2009), 'Differential activation of the human trigeminal nuclear complex by noxious and non-noxious orofacial stimulation', Human Brain Mapping, 11.
• Grewal, T., James, C. and Macefield, V. (2009), 'Frequency-dependent modulation of muscle sympathetic nerve activity by sinusoidal galvanic vestibular stimulation in human subjects', Experimental Brain Research, 8.
• Brown, R., Brown, R., Burton, A. and Macefield, V. (2009), 'Input-output relationships of a somatosympathetic reflex in human spinal injury', Clinical Autonomic Research, 8.
• Brown, R., Stolzenhein, G., Engel, S. and Macefield, V. (2009), 'Cutaneous vasoconstriction as a measure of incipient autonomic dysreflexia during penile vibratory stimulation in spinal cord injury', Spinal Cord, 7.
• Burton, A., Birznieks, I., Spaak, J., Henderson, L. and Macefield, V. (2009), 'Effects of deep and superficial experimentally induced acute pain on skin sympathetic nerve activity in human subjects', Experimental Brain Research, 8.
• Mcnulty, P., Galea, V., Fallon, J., Bent, L. and Macefield, V. (2008), 'Low threshold afferent signalling of viscous loads during voluntary movements of the human digits', Neuroreport, 6.
• Birznieks, I., Burton, A. and Macefield, V. (2008), 'The effects of experimental muscle and skin pain on the static stretch sensitivity of human muscle spindles in relaxed leg muscles', The Journal of Physiology, 11.
• Brown, R. and Macefield, V. (2008), 'Assessing the capacity of the sympathetic nervous system to respond to a cardiovascular challenge in human spinal cord injury', Spinal Cord, 7.
• Burton, A., Brown, R. and Macefield, V. (2008), 'Selective activation of muscle and skin nociceptors does not trigger exaggerated sympathetic responses in spinal-injured subjects', Spinal Cord, 6.
• Macefield, V., Sverrisdottir, Y., Elam, M. and Harris, J. (2008), 'Firing properties of sudomotor neurones in hyperhidrosis and thermal sweating', Clinical Autonomic Research, 6.
• Brown, R., Stolzenheim, G., Engel, S. and Macefield, V. (2008), 'Cutaneous vasoconstriction as a measure of incipient autonomic dysreflexia during penile vibratory stimulation in spinal cord injury', Spinal Cord, .
• Henderson, L., Gandevia, S. and Macefield, V. (2008), 'Gender differences in brain activity evoked by muscle and cutaneous pain: a retrospective study of single-trial fMRI data', NeuroImage, 10.
• Henderson, L., Gandevia, S. and Macefield, V. (2007), 'Discrete changes in cortical activation during experimentally induced referred muscle pain - a single fMRI study', Cerebral Cortex, 10.
• Clarke, E., Mcnulty, P., Macefield, V. and Bilston, L. (2007), 'Mechanically evoked sensory and motor responses to dynamic compression of the ulnar nerve', Muscle & Nerve, 9.
• Bent, L., Bolton, P. and Macefield, V. (2007), 'Vestibular inputs do not influence the fusimotor system in relaxed muscles of the human leg', Experimental Brain Research, 7.
• Lin, C., Macefield, V., Elam, M., Wallin, G., Engel, S. and Kiernan, M. (2007), 'Axonal changes in spinal cord injured patients distal to the site of injury', Brain, 10.
• Brown, R., Engel, S., Wallin, G., Elam, M. and Macefield, V. (2007), 'Assessing the integrity of sympathetic pathways in spinal cord injury', Autonomic Neuroscience: basic & clinical, 8.
• Fallon, J. and Macefield, V. (2007), 'Vibration sensitivity of human muscle spindles and Golgi tendon organs', Muscle & Nerve, 9.
• Henderson, L., Gandevia, S. and Macefield, V. (2007), 'Somatotopic organization of the processing of muscle and cutaneous pain in the left and right insula cortex: a single-trial fMRI study', Pain, 11.
• Macefield, V., Gandevia, S. and Henderson, L. (2006), 'Neural sites involved in the sustained increase in muscle sympathetic nerve activity induced by inspiratory-capacity apnea - a fMRI study', Journal of Applied Physiology, 8.
• Henderson, L., Bandlera, R., Gandevia, S. and Macefield, V. (2006), 'Distinct forebrain activity patterns during deep versus superficial pain', Pain, 11.
• Bent, L., Bolton, P. and Macefield, V. (2006), 'Modulation of muscle sympathetic bursts by sinusoidal galvanic vestibular stimulation in human subjects', Experimental Brain Research, 11.
• Fallon, J., Bent, L., McNulty, P. and Macefield, V. (2005), 'Evidence for strong synaptic coupling between single tactile afferents from the sole of the foot and motoneurons supplying leg muscles', Journal of Neurophysiology, 10.
• Klineberg, I., Calford, M., Dreher, B., Henry, P., Macefield, V., Miles, T., Rowe, M., Sessle, B. and Trulsson, M. (2005), 'A consensus statement on osseoperception', Clinical and Experimental Pharmacology and Physiology, 2.
• Macefield, V. (2005), 'Physiological characteristics of low-threshold mechanoreceptors in joints, muscle and skin in human subjects', Clinical and Experimental Pharmacology and Physiology, 10.
• Macefield, V. and Elam, M. (2004), 'Comparison of the firing patterns of human postganglionic sympathetic neurones and spinal I? motoneurones during brief bursts', Experimental Physiology, 7.
• Bolton, P., Wardman, D. and Macefield, V. (2004), 'Absence of short-term vestibular modulation of muscle sympathetic outflow, assessed by brief galvanic vestibular stimulation in awake human subjects', Experimental Brain Research, 5.
• Elam, M. and Macefield, V. (2004), 'Does sympathetic nerve discharge affect the firing of myelinated cutaneous afferents in humans?', Autonomic Neuroscience: Basic and Clinical, 11.
• Macefield, V., Sverrisdottir, Y. and Wallin, B. (2003), 'Resting discharge of human muscle spindles is not modulated by increases in sympathetic drive', Journal of Physiology, 7.
• Macefield, V. (2003), 'Cardiovascular and respiratory modulation of tactile afferents in the human finger pad', Experimental Physiology, 9.
• Macefield, V. and Johansson, R. (2003), 'Loads applied tangential to a fingertip during an object restraint task can trigger short-latency as well as long-latency EMG responses in hand muscles', Experimental Brain Research, 7.
• Macefield, V. and Elam, M. (2003), 'Why do human postganglionic neurones primarily only fire once during a sympathetic burst?', Acta Physiologica Scandinavica, 7.
• Elam, M., Sverrisdottir, Y., Rundqvist, B., Mckenzie, D., Wallin, B. and Macefield, V. (2003), 'Pathological sympathoexcitation: How is it achieved?', Acta Physiologica Scandinavica, 7.
• Elam, M., Mckenzie, D. and Macefield, V. (2002), 'Mechanisms of sympatho-excitation: single-unit analysis of muscle vasoconstrictor neurons in awake OSAS subjects', Journal of Applied Physiology, 7.
• McNulty, P., Macefield, V., Taylor, J. and Hallett, M. (2002), 'Cortically evoked neural volleys to the human hand are increased during ischaemic block of the forearm', Journal of Physiology, 10.
• Macefield, V. and Elam, M. (2002), 'Prolonged surges of baroreflex-resistant muscle sympathetic drive during periodic breathing', Clinical Autonomic Research, 5.
• McNulty, P. and Macefield, V. (2002), 'Reflexes in the hand: Strong synaptic coupling between single tactile afferents and spinal motoneurones', Advances in Experimental Medicine and Biology, 7.
• Elam, M. and Macefield, V. (2001), 'Multiple firing of single muscle vasoconstrictor neurons during cardiac dysrhythmias in human heart failure', Journal of Applied Physiology, 8.
• Mcnulty, P. and Macefield, V. (2001), 'Modulation of ongoing EMG by different classes of low threshold mechanoreceptors in the human hand', The Journal of Physiology, 12.